{"id":9964,"date":"2025-09-26T23:08:01","date_gmt":"2025-09-26T21:08:01","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-lancent-la-base-de-donnees-de-proteines-du-virus-humain-le-plus-complet-du-monde\/"},"modified":"2025-09-26T23:08:03","modified_gmt":"2025-09-26T21:08:03","slug":"les-scientifiques-lancent-la-base-de-donnees-de-proteines-du-virus-humain-le-plus-complet-du-monde","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-lancent-la-base-de-donnees-de-proteines-du-virus-humain-le-plus-complet-du-monde\/","title":{"rendered":"Les scientifiques lancent la base de donn\u00e9es de prot\u00e9ines du virus humain le plus complet du monde"},"content":{"rendered":"
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Exploitant le pouvoir de l’IA, une \u00e9quipe de recherche de la MRC-University of Glasgow Center for Virus Research a lanc\u00e9 Viro3D – la base de donn\u00e9es la plus compl\u00e8te des pr\u00e9dictions de la structure des prot\u00e9ines de virus humain et animal dans le monde.<\/p>\n

La base de donn\u00e9es gratuite et consultable aliment\u00e9e par AI offre une perspective compl\u00e8tement nouvelle et approfondie sur les virus, ce qui nous permet d’en savoir plus sur leurs origines et leur \u00e9volution.<\/p>\n

Bien que les particules virales soient les entit\u00e9s biologiques les plus abondantes de notre plan\u00e8te, ces minuscules structures restent parmi les moins bien compris. Des informations sur les principales structures prot\u00e9iques au sein des virus n’ont, jusqu’\u00e0 pr\u00e9sent, \u00e9t\u00e9 obtenu que par des travaux de recherche lents et laborieux, un rythme qui a eu un impact sur notre capacit\u00e9 \u00e0 d\u00e9velopper des traitements et des vaccins \u00e0 grande vitesse.<\/p>\n

Maintenant, dans un effort pour acc\u00e9l\u00e9rer notre compr\u00e9hension, une \u00e9quipe de chercheurs, dirig\u00e9e par le Dr Joe Grove dans le MRC-University of Glasgow Center for Virus Research, a exploit\u00e9 le pouvoir de l’IA pour cr\u00e9er une nouvelle base de donn\u00e9es de milliers de prot\u00e9ines virales humaines et animales.<\/p>\n

Viro3D contient des mod\u00e8les structurels de haute qualit\u00e9 pour 85 000 prot\u00e9ines provenant de 4 400 virus humains et animaux – la plus grande base de donn\u00e9es de mod\u00e8les structurels complets pour les virus humains et animaux, \u00e9largissant nos connaissances actuelles dans ce domaine \u00e0 30 fois.<\/p>\n

Les cr\u00e9ateurs de Viro3d s’attendent \u00e0 ce que la base de donn\u00e9es commencera une nouvelle \u00e8re pour la recherche sur le virus humain et animal et acc\u00e9l\u00e8re le d\u00e9veloppement de m\u00e9dicaments antiviraux et de vaccins contre les virus end\u00e9miques existants, tels que l’h\u00e9patite, le VIH, le rhume et le Covid-19 communs, ainsi que pour les menaces pand\u00e9miques nouvelles et \u00e9mergentes.<\/p>\n

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La base de donn\u00e9es, qui a \u00e9t\u00e9 r\u00e9cemment d\u00e9taill\u00e9e dans le journal Biologie des syst\u00e8mes mol\u00e9culaires<\/i>a d\u00e9j\u00e0 r\u00e9v\u00e9l\u00e9 des informations auparavant inconnues sur l’ascendance g\u00e9n\u00e9tique de SARS-COV-2, le virus responsable de Covid-19.<\/p>\n

Les donn\u00e9es de Viro3D sugg\u00e8rent qu’une prot\u00e9ine cl\u00e9 dans SARS-CoV-2, l’une des responsables de l’infection, peut \u00eatre \u00e0 l’origine provenant d’un \u00e9change g\u00e9n\u00e9tique avec un herp\u00e8svirus ancestral, la famille des virus responsable d’une gamme de maladies, notamment des boutons de froid et de la variole.<\/p>\n

L’\u00e9quipe de recherche affirme que Viro3D a le potentiel de g\u00e9n\u00e9rer beaucoup plus d’informations comme celle-ci – sur l’histoire et les origines \u00e9volutives des virus – pour des milliers de prot\u00e9ines diff\u00e9rentes, aidant \u00e0 turbier notre compr\u00e9hension des virus humains et animaux, et \u00e0 leur tour notre capacit\u00e9 \u00e0 les combattre au rythme.<\/p>\n

Le Dr Joe Grove, auteur principal de la MRC-University of Glasgow Center for Virus Research, a d\u00e9clar\u00e9: \u00ab\u00a0Nous ne sommes qu’au d\u00e9but de la compr\u00e9hension de l’\u00e9norme diversit\u00e9 g\u00e9n\u00e9tique au sein de la communaut\u00e9 virale. Les virus sont aussi anciens que la vie cellulaire, ayant depuis des milliards d’ann\u00e9es.<\/p>\n

\u00ab\u00a0Viro3d offre une toute nouvelle perspective sur les virus, nous permettant de d\u00e9couvrir leurs origines et leur \u00e9volution. Nous nous attendons \u00e0 ce que Viro3D et l’intelligence artificielle acc\u00e9l\u00e8rent la conception informatique des m\u00e9dicaments antiviraux et des vaccins contre les virus end\u00e9miques existants. Nous pouvons ensuite ramener ces conceptions dans les laboratoires et ensuite au monde r\u00e9el.\u00a0\u00bb<\/p>\n

Les prot\u00e9ines sont les \u00e9l\u00e9ments constitutifs de la vie, remplissant une vaste gamme de fonctions pour nos cellules et jouant un r\u00f4le critique \u00e0 la fois dans la sant\u00e9 et la maladie. Afin de comprendre comment fonctionnent les prot\u00e9ines, les chercheurs doivent \u00eatre en mesure d’examiner leur structure tridimensionnelle.<\/p>\n

Alors que les progr\u00e8s de l’intelligence artificielle ont conduit \u00e0 la cr\u00e9ation de bases de donn\u00e9es g\u00e9n\u00e9rales de structure des prot\u00e9ines, telles que la base de donn\u00e9es Alphafold et l’atlas m\u00e9tag\u00e9nomique de mod\u00e9lisation de l’\u00e9chelle \u00e9volutive, les prot\u00e9ines virales ont jusqu’\u00e0 pr\u00e9sent \u00e9t\u00e9 exclues des efforts de pr\u00e9diction ou seulement inclus en petit nombre.<\/p>\n

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Exploitant le pouvoir de l’IA, une \u00e9quipe de recherche de la MRC-University of Glasgow Center<\/p>\n","protected":false},"author":1,"featured_media":9965,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[1601,4647,98,1175,6280,49,1482,1204,97,630],"class_list":["post-9964","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-base","tag-complet","tag-donnees","tag-humain","tag-lancent","tag-les","tag-monde","tag-proteines","tag-scientifiques","tag-virus","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLes scientifiques lancent la base de donn\u00e9es de prot\u00e9ines du virus humain le plus complet du monde - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-lancent-la-base-de-donnees-de-proteines-du-virus-humain-le-plus-complet-du-monde\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les scientifiques lancent la base de donn\u00e9es de prot\u00e9ines du virus humain le plus complet du monde - 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