{"id":9871,"date":"2025-09-25T01:03:18","date_gmt":"2025-09-24T23:03:18","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/aliments-ultra-transformes-lies-a-une-activite-accrue-de-la-maladie-dans-la-sclerose-en-plaques-precoces\/"},"modified":"2025-09-25T01:03:30","modified_gmt":"2025-09-24T23:03:30","slug":"aliments-ultra-transformes-lies-a-une-activite-accrue-de-la-maladie-dans-la-sclerose-en-plaques-precoces","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/aliments-ultra-transformes-lies-a-une-activite-accrue-de-la-maladie-dans-la-sclerose-en-plaques-precoces\/","title":{"rendered":"Aliments ultra-transform\u00e9s li\u00e9s \u00e0 une activit\u00e9 accrue de la maladie dans la scl\u00e9rose en plaques pr\u00e9coces"},"content":{"rendered":"
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Un apport plus \u00e9lev\u00e9 d’aliments ultra-transform\u00e9s (UPF) peut exacerber l’activit\u00e9 de la maladie dans la scl\u00e9rose en plaques pr\u00e9coces (SEP), selon de nouvelles recherches pr\u00e9sent\u00e9es au 41e Congr\u00e8s du Comit\u00e9 europ\u00e9en pour le traitement et la recherche sur la scl\u00e9rose en plaques (Ectrims 2025).<\/p>\n

Les chercheurs ont constat\u00e9 qu’une augmentation de la consommation de l’UPF \u00e9tait li\u00e9e \u00e0 des rechutes plus fr\u00e9quentes et \u00e0 une plus grande activit\u00e9 de l\u00e9sions d\u00e9tect\u00e9es par l’IRM, mettant en \u00e9vidence le r\u00f4le potentiel de l’alimentation en tant que strat\u00e9gie compl\u00e9mentaire dans la gestion des maladies.<\/p>\n

L’\u00e9tude, dirig\u00e9e par la Dre Gloria Dalla Costa, a analys\u00e9 les donn\u00e9es de 451 patients atteints du syndrome cliniquement isol\u00e9 – la premi\u00e8re pr\u00e9sentation clinique de la SEP – qui a \u00e9t\u00e9 inscrite \u00e0 l’essai de prestations et suivi jusqu’\u00e0 cinq ans.<\/p>\n

Une signature m\u00e9tabolomique pr\u00e9c\u00e9demment valid\u00e9e de l’apport UPF, comprenant 39 m\u00e9tabolites plasmatiques d\u00e9velopp\u00e9es par les coll\u00e8gues de Harvard, a \u00e9t\u00e9 appliqu\u00e9e aux \u00e9chantillons de plasma de base pour calculer les scores UPF individuels.<\/p>\n

Bien que les scores UPF n’\u00e9taient pas associ\u00e9s \u00e0 la conversion en SEP cliniquement d\u00e9finie, les scores plus \u00e9lev\u00e9s au d\u00e9part \u00e9taient li\u00e9s \u00e0 un plus grand volume de l\u00e9sion de l’hypointense, indiquant des dommages tissulaires plus graves et des scores de fonctions neurologiques plus faibles.<\/p>\n

Au cours du suivi de cinq ans, les participants du quartile UPF le plus \u00e9lev\u00e9 ont connu environ 30% de rechutes plus que celles du quartile le plus bas.<\/p>\n

\u00c0 deux ans, ils avaient \u00e9galement un taux plus \u00e9lev\u00e9 de nouvelles l\u00e9sions actives, repr\u00e9sentant une inflammation continue et une augmentation plus importante du volume des l\u00e9sions T2, un marqueur de l’accumulation de changements tissulaires. Ces associations sont rest\u00e9es significatives apr\u00e8s l’ajustement de l’\u00e2ge, du sexe, de l’allocation du traitement, de la charge de la maladie de base, de l’IMC, de la vitamine D et du tabagisme.<\/p>\n

\u00ab\u00a0Ce mod\u00e8le sugg\u00e8re que les aliments ultra-transform\u00e9s agissent comme un acc\u00e9l\u00e9rateur inflammatoire chronique plut\u00f4t que comme un d\u00e9clencheur de maladie, amplifiant les processus inflammatoires existants dans la SEP plut\u00f4t que de d\u00e9terminer si une personne d\u00e9veloppe la maladie en premier lieu\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Dalla Costa.<\/p>\n

\u00ab\u00a0Les m\u00e9canismes biologiques derri\u00e8re cet effet peuvent impliquer une perturbation de la barri\u00e8re intestinale par des additifs tels que les \u00e9mulsifiants et les conservateurs, ce qui peut permettre aux endotoxines bact\u00e9riennes d’entrer dans la circulation sanguine et de d\u00e9clencher l’activation immunitaire qui atteint le cerveau\u00a0\u00bb, a-t-elle expliqu\u00e9.<\/p>\n

\u00ab\u00a0Les c\u00e9ramides \u00e9lev\u00e9s et les lipides modifi\u00e9s sugg\u00e8rent que la consommation d’UPF peut \u00e9galement modifier la composition de la membrane, ce qui rend la my\u00e9line – la couche isolante qui se forme autour des nerfs – et les cellules qui le produisent plus vuln\u00e9rable \u00e0 l’attaque auto-immune.\u00a0\u00bb<\/p>\n

\u00ab\u00a0En outre, les signatures de stress m\u00e9tabolique telles que la carnitine C4-OH \u00e9lev\u00e9e pointent vers une alt\u00e9ration de la production d’\u00e9nergie cellulaire, limitant la capacit\u00e9 du cerveau \u00e0 r\u00e9sister et \u00e0 r\u00e9parer les dommages lors d’\u00e9pisodes inflammatoires. Dans l’ensemble, nos r\u00e9sultats sugg\u00e8rent que la consommation UPFR cr\u00e9e une cascade de perturbations biologiques qui amplifient l’activit\u00e9 inflammatoire de la SEP.\u00a0\u00bb<\/p>\n

Discutant des implications cliniques des r\u00e9sultats, le Dr Dalla Costa a d\u00e9clar\u00e9: \u00ab\u00a0Je recommanderais la r\u00e9duction de l’UPF en tant que pr\u00e9cieuse strat\u00e9gie de soutien pour la gestion pr\u00e9coce de la SEP. Similaire \u00e0 la suppl\u00e9mentation en vitamine D ou aux conseils de sevrage tabagique, il ne s’agit pas de remplacer les th\u00e9rapies \u00e9tablies, mais de les compl\u00e9ter.<\/p>\n

Pour l’avenir, l’\u00e9quipe pr\u00e9voit de reproduire ces r\u00e9sultats dans d’autres cohortes MS, d’int\u00e9grer l’analyse du microbiome et des \u00e9tudes d’intervention de conception.<\/p>\n

\u00ab\u00a0Nous finalisons un manuscrit complet qui fournira la base de preuves n\u00e9cessaires pour \u00e9clairer les directives de pratique clinique et \u00e9tablir les bases de futures \u00e9tudes d’intervention alimentaire\u00a0\u00bb, conclut le Dr Dalla Costa.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par le Comit\u00e9 europ\u00e9en pour le traitement et la recherche sur la scl\u00e9rose en plaques<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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