{"id":974,"date":"2024-10-01T02:14:11","date_gmt":"2024-10-01T00:14:11","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/"},"modified":"2024-10-01T02:14:11","modified_gmt":"2024-10-01T00:14:11","slug":"des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/","title":{"rendered":"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves"},"content":{"rendered":"
\n
\n
\n
\n<\/figure><\/div>\n<\/div>\n

Des chercheurs du Baylor College of Medicine et d’institutions collaboratrices ont d\u00e9couvert un m\u00e9canisme qui entra\u00eene le d\u00e9clin \u00e0 long terme de la r\u00e9ponse immunitaire observ\u00e9 apr\u00e8s le traitement r\u00e9ussi de la tuberculose (TB). Leurs conclusions, publi\u00e9es dans le Actes de l’Acad\u00e9mie nationale des sciences<\/i>sugg\u00e8rent une nouvelle fa\u00e7on potentielle de restaurer la r\u00e9activit\u00e9 immunitaire et de r\u00e9duire le risque de mortalit\u00e9 apr\u00e8s des infections graves.<\/p>\n

\u00ab\u00a0La septic\u00e9mie et la tuberculose sont associ\u00e9es \u00e0 une perte de r\u00e9ponses immunitaires protectrices et \u00e0 une mortalit\u00e9 accrue apr\u00e8s un traitement r\u00e9ussi\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Andrew DiNardo, auteur correspondant et professeur agr\u00e9g\u00e9 dans la section des maladies infectieuses et la division de la sant\u00e9 p\u00e9diatrique mondiale et des immigrants au Baylor College of Medicine. et l’h\u00f4pital pour enfants du Texas. \u00ab\u00a0Dans la pr\u00e9sente \u00e9tude, nous avons \u00e9tudi\u00e9 ce qui intervenait dans la perturbation de la fonction immunitaire apr\u00e8s des infections graves.\u00a0\u00bb<\/p>\n

Les chercheurs savent que les infections graves et chroniques chez les humains et les animaux entra\u00eenent des changements \u00e9pig\u00e9n\u00e9tiques persistants et durables. Ces changements font r\u00e9f\u00e9rence \u00e0 des alt\u00e9rations des marquages \u200b\u200bchimiques sur l\u2019ADN qui indiquent aux cellules du corps quels g\u00e8nes activer ou d\u00e9sactiver.<\/p>\n

Par exemple, la tuberculose att\u00e9nue la r\u00e9activit\u00e9 immunitaire en ajoutant des marqueurs chimiques m\u00e9thyliques suppl\u00e9mentaires (m\u00e9thylation de l\u2019ADN) \u00e0 certains g\u00e8nes impliqu\u00e9s dans les r\u00e9ponses immunitaires. Cela entra\u00eene \u00e0 son tour une diminution de la production de prot\u00e9ines m\u00e9diatrices de la d\u00e9fense immunitaire et une susceptibilit\u00e9 accrue aux infections. Cependant, les m\u00e9canismes induisant des changements \u00e9pig\u00e9n\u00e9tiques dans les infections n\u2019\u00e9taient pas clairs.<\/p>\n

Des \u00e9tudes ant\u00e9rieures ont identifi\u00e9 le cycle de l’acide tricarboxylique (TCA), un \u00e9l\u00e9ment cl\u00e9 du m\u00e9tabolisme cellulaire, comme un moteur m\u00e9tabolique du paysage \u00e9pig\u00e9n\u00e9tique du cancer. DiNardo et ses coll\u00e8gues voulaient voir si le TCA r\u00e9gulait \u00e9galement l’\u00e9pig\u00e9n\u00e9tique, en particulier la m\u00e9thylation de l’ADN, apr\u00e8s une tol\u00e9rance immunitaire induite par une infection.<\/p>\n

L\u2019\u00e9quipe a rapport\u00e9 que les cellules immunitaires humaines trait\u00e9es en laboratoire avec un lipopolysaccharide bact\u00e9rien, un produit bact\u00e9rien, et Mycobacterium tuberculosis, la bact\u00e9rie responsable de la tuberculose, sont devenues immunotol\u00e9rantes. Ils ont \u00e9galement constat\u00e9 que les patients diagnostiqu\u00e9s \u00e0 la fois avec un sepsis et une tuberculose pr\u00e9sentaient une activation accrue du TCA, ce qui est en corr\u00e9lation avec la m\u00e9thylation de l’ADN.<\/p>\n

Lorsque les patients tuberculeux ont re\u00e7u le traitement standard et les antibiotiques, ainsi que l’\u00e9v\u00e9rolimus, un inhibiteur de l’activation du TCA, les modifications dommageables de la m\u00e9thylation de leur ADN ont \u00e9t\u00e9 r\u00e9duites, ce qui sugg\u00e8re que cela peut aider \u00e0 restaurer le syst\u00e8me immunitaire apr\u00e8s des infections graves.<\/p>\n

\u00ab\u00a0La tuberculose est une maladie int\u00e9ressante. Au moment o\u00f9 une personne est diagnostiqu\u00e9e, elle pr\u00e9sente des sympt\u00f4mes depuis plus de trois mois. En ajoutant de l’\u00e9v\u00e9rolimus au traitement antibiotique standard contre la tuberculose, le nombre de marques nuisibles de m\u00e9thylation de l’ADN est r\u00e9duit six mois apr\u00e8s le d\u00e9but du processus pathologique. promettant que nous pouvons induire une gu\u00e9rison \u00e9pig\u00e9n\u00e9tique\u00a0\u00bb, a d\u00e9clar\u00e9 DiNardo.<\/p>\n

\u00ab\u00a0Ce que nous avons d\u00e9couvert va conduire \u00e0 un changement de paradigme\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Cristian Coarfa, co-auteur et professeur agr\u00e9g\u00e9 de biologie mol\u00e9culaire et cellulaire \u00e0 Baylor. \u00ab\u00a0Nos approches ne se limitent pas \u00e0 la tuberculose. Les preuves dont nous disposons et sur lesquelles nous essayons de nous appuyer sugg\u00e8rent que ces strat\u00e9gies pourraient jouer un r\u00f4le dans d’autres maladies infectieuses.\u00a0\u00bb<\/p>\n

La prochaine \u00e9tape pour les chercheurs consiste \u00e0 identifier les marques \u00e9pig\u00e9n\u00e9tiques post-TB qui entra\u00eenent une morbidit\u00e9 et une mortalit\u00e9 accrues. \u00c0 partir de l\u00e0, ils aimeraient d\u00e9terminer quelles personnes b\u00e9n\u00e9ficieraient le plus d\u2019une th\u00e9rapie dirig\u00e9e par l\u2019h\u00f4te capable de gu\u00e9rir les cicatrices \u00e9pig\u00e9n\u00e9tiques.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs du Baylor College of Medicine et d’institutions collaboratrices ont d\u00e9couvert un m\u00e9canisme qui<\/p>\n","protected":false},"author":1,"featured_media":819,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[217,288,364,16,581,1259,607,1257,1256,1258],"class_list":["post-974","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-apres","tag-chercheurs","tag-decouvrent","tag-des","tag-graves","tag-immunitaires","tag-infections","tag-lorigine","tag-mecanisme","tag-perturbations","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nDes chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"Des chercheurs du Baylor College of Medicine et d’institutions collaboratrices ont d\u00e9couvert un m\u00e9canisme qui\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\" \/>\n<meta property=\"og:site_name\" content=\"RVH-Synergie\" \/>\n<meta property=\"article:published_time\" content=\"2024-10-01T00:14:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1991\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Charles Martinez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Charles Martinez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\"},\"author\":{\"name\":\"Charles Martinez\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\"},\"headline\":\"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves\",\"datePublished\":\"2024-10-01T00:14:11+00:00\",\"dateModified\":\"2024-10-01T00:14:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\"},\"wordCount\":720,\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg\",\"keywords\":[\"apr\u00e8s\",\"chercheurs\",\"d\u00e9couvrent\",\"des\",\"graves\",\"immunitaires\",\"infections\",\"lorigine\",\"m\u00e9canisme\",\"perturbations\"],\"articleSection\":[\"Les maladies\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\",\"name\":\"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves - RVH-Synergie.org\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg\",\"datePublished\":\"2024-10-01T00:14:11+00:00\",\"dateModified\":\"2024-10-01T00:14:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg\",\"width\":2560,\"height\":1991,\"caption\":\"La prot\u00e9ine Tribbles offre de l'espoir pour le traitement de la tuberculose\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/rvh-synergie.org\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"name\":\"RVH-Synergie.org\",\"description\":\"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.\",\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\",\"name\":\"RVH-Synergie.org\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"width\":512,\"height\":512,\"caption\":\"RVH-Synergie.org\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\",\"name\":\"Charles Martinez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"caption\":\"Charles Martinez\"},\"description\":\"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.\",\"sameAs\":[\"https:\/\/rvh-synergie.org\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves - RVH-Synergie.org","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/","og_locale":"fr_FR","og_type":"article","og_title":"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves - RVH-Synergie.org","og_description":"Des chercheurs du Baylor College of Medicine et d’institutions collaboratrices ont d\u00e9couvert un m\u00e9canisme qui","og_url":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/","og_site_name":"RVH-Synergie","article_published_time":"2024-10-01T00:14:11+00:00","og_image":[{"width":2560,"height":1991,"url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg","type":"image\/jpeg"}],"author":"Charles Martinez","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Charles Martinez","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#article","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/"},"author":{"name":"Charles Martinez","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560"},"headline":"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves","datePublished":"2024-10-01T00:14:11+00:00","dateModified":"2024-10-01T00:14:11+00:00","mainEntityOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/"},"wordCount":720,"publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg","keywords":["apr\u00e8s","chercheurs","d\u00e9couvrent","des","graves","immunitaires","infections","lorigine","m\u00e9canisme","perturbations"],"articleSection":["Les maladies"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/","url":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/","name":"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves - RVH-Synergie.org","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#website"},"primaryImageOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg","datePublished":"2024-10-01T00:14:11+00:00","dateModified":"2024-10-01T00:14:11+00:00","breadcrumb":{"@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#primaryimage","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/1727232982_La-proteine-Tribbles-offre-de-lespoir-pour-le-traitement-de-scaled.jpg","width":2560,"height":1991,"caption":"La prot\u00e9ine Tribbles offre de l'espoir pour le traitement de la tuberculose"},{"@type":"BreadcrumbList","@id":"https:\/\/rvh-synergie.org\/actualites\/des-chercheurs-decouvrent-un-mecanisme-a-lorigine-des-perturbations-immunitaires-apres-des-infections-graves\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/rvh-synergie.org\/actualites\/"},{"@type":"ListItem","position":2,"name":"Des chercheurs d\u00e9couvrent un m\u00e9canisme \u00e0 l\u2019origine des perturbations immunitaires apr\u00e8s des infections graves"}]},{"@type":"WebSite","@id":"https:\/\/rvh-synergie.org\/actualites\/#website","url":"https:\/\/rvh-synergie.org\/actualites\/","name":"RVH-Synergie.org","description":"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.","publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/rvh-synergie.org\/actualites\/#organization","name":"RVH-Synergie.org","url":"https:\/\/rvh-synergie.org\/actualites\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","width":512,"height":512,"caption":"RVH-Synergie.org"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560","name":"Charles Martinez","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","caption":"Charles Martinez"},"description":"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.","sameAs":["https:\/\/rvh-synergie.org\/"]}]}},"_links":{"self":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/comments?post=974"}],"version-history":[{"count":0,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/974\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media\/819"}],"wp:attachment":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media?parent=974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/categories?post=974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/tags?post=974"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}