{"id":9677,"date":"2025-09-19T18:47:17","date_gmt":"2025-09-19T16:47:17","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/la-bacterie-de-la-tuberculose-desactive-le-capteur-immunitaire-cle-pour-echapper-aux-defenses-de-lhote-letude-revele\/"},"modified":"2025-09-19T18:47:21","modified_gmt":"2025-09-19T16:47:21","slug":"la-bacterie-de-la-tuberculose-desactive-le-capteur-immunitaire-cle-pour-echapper-aux-defenses-de-lhote-letude-revele","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/la-bacterie-de-la-tuberculose-desactive-le-capteur-immunitaire-cle-pour-echapper-aux-defenses-de-lhote-letude-revele\/","title":{"rendered":"La bact\u00e9rie de la tuberculose d\u00e9sactive le capteur immunitaire cl\u00e9 pour \u00e9chapper aux d\u00e9fenses de l&rsquo;h\u00f4te, l&rsquo;\u00e9tude r\u00e9v\u00e8le"},"content":{"rendered":"<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2025\/scientists-reveal-path.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2025\/scientists-reveal-path.jpg\" data-sub-html=\"Mtb PknG hijacks the host linear ubiquitin chain assembly complex to evade NLRP3 inflammasome-mediated cytosolic immune surveillance. Credit: Liu Cuihua's group\">\n<figure class=\"article-img\">\n<\/figure><\/div>\n<\/div>\n<p>Une \u00e9quipe de recherche a d\u00e9couvert un nouveau m\u00e9canisme qui permet \u00e0 Mycobacterium tuberculosis (MTB), la bact\u00e9rie qui provoque la tuberculose (TB), pour \u00e9chapper aux d\u00e9fenses immunitaires h\u00f4tes.<\/p>\n<p>L&rsquo;\u00e9tude, publi\u00e9e dans <i>Rapports cellulaires<\/i>montre comment VTT d\u00e9tourne la machinerie d&rsquo;ubiquitine lin\u00e9aire de l&rsquo;h\u00f4te pour g\u00e9n\u00e9rer une d\u00e9gradation du capteur inflammasome NLRP3, contrecarrant ainsi la surveillance immunitaire intracellulaire de l&rsquo;h\u00f4te.<\/p>\n<p>Le VTT continue de menacer les patients en raison de l&rsquo;\u00e9mergence et de la propagation de la r\u00e9sistance aux antimicrobiens. Les cellules immunitaires de l&rsquo;h\u00f4te ont des capteurs cytosoliques qui d\u00e9tectent des agents pathog\u00e8nes envahisseurs et d\u00e9clenchent des r\u00e9ponses anti-infectieuses. Cependant, la fa\u00e7on dont les agents pathog\u00e8nes tels que le VTT sapent la surveillance intracellulaire de l&rsquo;h\u00f4te pour provoquer une infection persistante n&rsquo;est pas enti\u00e8rement comprise.<\/p>\n<p>Dans cette \u00e9tude, les chercheurs, dirig\u00e9s par le professeur Liu Cuihua de l&rsquo;Institut de microbiologie de l&rsquo;Acad\u00e9mie chinoise des sciences, ont constat\u00e9 que PKNG, une prot\u00e9ine kinase s\u00e9cr\u00e9t\u00e9e par le MTB, perturbe les r\u00e9ponses immunitaires m\u00e9di\u00e9es par le NLRP3 en interf\u00e9rant avec le complexe d&rsquo;assemblage de la cha\u00eene ubiquitine lin\u00e9aire (Lubac).<\/p>\n<p>M\u00e9caniquement, PKNG phosphoryle la sous-unit\u00e9 HOIL-1L de Lubac, emp\u00eachant Hoil-1l de participer \u00e0 la formation de Lubac. Cette perturbation alt\u00e8re l&rsquo;ubiquitination lin\u00e9aire d\u00e9pendant du lubac de l&rsquo;adaptateur inflammasome ASC, inhibant finalement l&rsquo;assemblage inflammasome NLRP3.<\/p>\n<p>De plus, la phosphorylation m\u00e9di\u00e9e par PKNG active simultan\u00e9ment l&rsquo;activit\u00e9 intrins\u00e8que de l&rsquo;ubiquitine ligase de HOIL-1L, permettant \u00e0 HOIL-1L de m\u00e9dier l&rsquo;ubiquitination li\u00e9e \u00e0 K48 et une d\u00e9gradation subs\u00e9quente de NLRP3.<\/p>\n<p>Pour r\u00e9sumer, gr\u00e2ce \u00e0 ce m\u00e9canisme \u00e0 double r\u00e9gulation qui r\u00e9alise l&rsquo;effet \u00ab\u00a0une seule pierre-birds\u00a0\u00bb comme mentionn\u00e9 ci-dessus, PKNG peut aider \u00e0 promouvoir l&rsquo;\u00e9vasion du MTB de la surveillance immunitaire cytoplasmique m\u00e9di\u00e9e par NLRP3, facilitant ainsi davantage la survie intracellulaire et l&rsquo;infection de l&rsquo;agent pathog\u00e8ne.<\/p>\n<p>Cette \u00e9tude r\u00e9v\u00e8le que le MTB exploite la dynamique d\u00e9pendante de la phosphorylation de la machinerie d&rsquo;ubiquitine lin\u00e9aire h\u00f4te par l&rsquo;interaction PKNG \/ HOIL-1L. Cette interaction forme une cascade enzymatique inter-esp\u00e8ces qui entra\u00eene une d\u00e9gradation du capteur inflammasome, permettant au MTB de contrer la surveillance immunitaire d\u00e9pendante du NLRP3.<\/p>\n<p>Ces r\u00e9sultats fournissent \u00e9galement une strat\u00e9gie potentielle pour le traitement anti-TB et l&rsquo;optimisation du vaccin Bacille Calmette-Gu\u00e9rin (BCG) en ciblant l&rsquo;interface PKNG \/ HOIL-1L.<\/p>\n<p>                                        <!-- print only --><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Une \u00e9quipe de recherche a d\u00e9couvert un nouveau m\u00e9canisme qui permet \u00e0 Mycobacterium tuberculosis (MTB),<\/p>\n","protected":false},"author":1,"featured_media":9678,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[171,3233,6725,666,2535,6724,6008,834,1346,968,8,157,1037],"class_list":["post-9677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-aux","tag-bacterie","tag-capteur","tag-cle","tag-defenses","tag-desactive","tag-echapper","tag-immunitaire","tag-letude","tag-lhote","tag-pour","tag-revele","tag-tuberculose","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.4 - 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