{"id":9605,"date":"2025-09-18T08:56:56","date_gmt":"2025-09-18T06:56:56","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-facon-de-detecter-ladn-tumoral-dans-lurine-peut-identifier-le-cancer-de-la-vessie\/"},"modified":"2025-09-18T08:57:01","modified_gmt":"2025-09-18T06:57:01","slug":"une-nouvelle-facon-de-detecter-ladn-tumoral-dans-lurine-peut-identifier-le-cancer-de-la-vessie","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-facon-de-detecter-ladn-tumoral-dans-lurine-peut-identifier-le-cancer-de-la-vessie\/","title":{"rendered":"Une nouvelle fa\u00e7on de d\u00e9tecter l’ADN tumoral dans l’urine peut identifier le cancer de la vessie"},"content":{"rendered":"
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Des chercheurs du Centre de recherche sur le cancer de la vessie de l’Universit\u00e9 de Birmingham ont utilis\u00e9 une nouvelle m\u00e9thode pour d\u00e9tecter les changements chimiques dans l’ADN dans l’\u00e9chantillon d’urine d’un individu; changements \u00e9pig\u00e9n\u00e9tiques, appel\u00e9s m\u00e9thylation.<\/p>\n

Publi\u00e9 dans \u00c9pig\u00e9n\u00e9tique clinique<\/i>ces changements pourraient \u00eatre utilis\u00e9s pour indiquer la pr\u00e9sence d’un cancer de la vessie.<\/p>\n

Bien que les tests d’urine de diagnostic actuels de pointe, tels que le test de la vessie des formes de l’\u00e9quipe, soient d\u00e9j\u00e0 tr\u00e8s pr\u00e9cis et commencent \u00e0 \u00eatre utilis\u00e9s dans le service national de sant\u00e9 du Royaume-Uni, ils s’appuient sur l’analyse (s\u00e9quen\u00e7age) de petits segments d’ADN.<\/p>\n

La nouvelle approche de l’\u00e9quipe examine les changements de m\u00e9thylation sur toute la longueur de l’ADN dans un \u00e9chantillon d’urine, la premi\u00e8re \u00e9tude pour cartographier ces mod\u00e8les en utilisant une nouvelle technologie de s\u00e9quen\u00e7age d’ADN.<\/p>\n

M\u00eame si les \u00e9chantillons d’urine des patients contenaient de l’ADN \u00e0 la fois des cellules saines et canc\u00e9reuses, l’\u00e9quipe a pu discriminer le cancer des patients non cancer, m\u00eame si le niveau d’ADN tumoral \u00e9tait faible. Cette approche peut constituer la base d’une prochaine g\u00e9n\u00e9ration de tests d’urine diagnostique qui pourraient r\u00e9v\u00e9ler des caract\u00e9ristiques suppl\u00e9mentaires de l’ADN tumoral, y compris celles d\u00e9tect\u00e9es par le test de la vessie des formes.<\/p>\n

Le professeur Rik Bryan, professeur de recherche sur le cancer uroth\u00e9lial et directeur du Centre de recherche sur le cancer de la vessie de l’Universit\u00e9 de Birmingham, a d\u00e9clar\u00e9: \u00ab\u00a0Ce sont des donn\u00e9es tr\u00e8s int\u00e9ressantes et passionnantes, et comme pour toutes les recherches sur le cancer, nos r\u00e9sultats suscitent de nombreuses questions ainsi que des r\u00e9ponses.<\/p>\n

\u00ab\u00a0Cependant, cette approche de s\u00e9quen\u00e7age \u00e0 lutte longue peut nous permettre de mieux comprendre les tout premiers changements de la vessie qui conduisent finalement au d\u00e9veloppement d’une tumeur de la vessie. \u00c0 son tour, cela peut alors nous permettre de livrer un nouveau type de test d’urine, mais il y a encore un long chemin \u00e0 parcourir.\u00a0\u00bb<\/p>\n

Dr. Anshita Goel, Bioinformatic Research Fellow, said, \u00ab\u00a0Our proof-of-concept study offers a glimpse of what could be achievable in a clinical setting: a comprehensive, non-invasive test that could surpass today’s clinical methods. With nothing more than a urine sample and cost-effective sequencing technology, we can uncover the hidden epigenetic signatures of bladder cancer\u2014opening the door to faster, gentler, and more D\u00e9tection des maladies adapt\u00e9es aux patients \u00e0 l’avenir. \u00ab\u00a0<\/p>\n

Les donn\u00e9es g\u00e9n\u00e9r\u00e9es par la nouvelle approche sont \u00e9tendues, et l’\u00e9quipe commence maintenant \u00e0 d\u00e9velopper des m\u00e9thodes d’intelligence artificielle qui peuvent classer les patients en fonction de leurs mod\u00e8les de m\u00e9thylation de l’ADN, dans le but ultime de les diriger vers la voie de traitement optimale.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs du Centre de recherche sur le cancer de la vessie de l’Universit\u00e9 de<\/p>\n","protected":false},"author":1,"featured_media":9606,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[391,44,856,546,719,1172,6664,244,669,6709,47,4358],"class_list":["post-9605","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-cancer","tag-dans","tag-detecter","tag-facon","tag-identifier","tag-ladn","tag-lurine","tag-nouvelle","tag-peut","tag-tumoral","tag-une","tag-vessie","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne nouvelle fa\u00e7on de d\u00e9tecter l'ADN tumoral dans l'urine peut identifier le cancer de la vessie - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-facon-de-detecter-ladn-tumoral-dans-lurine-peut-identifier-le-cancer-de-la-vessie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une nouvelle fa\u00e7on de d\u00e9tecter l'ADN tumoral dans l'urine peut identifier le cancer de la vessie - 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