{"id":9417,"date":"2025-09-12T19:55:12","date_gmt":"2025-09-12T17:55:12","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/les-niveaux-dantigene-de-surface-a-faible-hepatite-b-signalent-un-risque-minimal-de-cancer-du-foie-redefinir-cure-partielle\/"},"modified":"2025-09-12T19:55:14","modified_gmt":"2025-09-12T17:55:14","slug":"les-niveaux-dantigene-de-surface-a-faible-hepatite-b-signalent-un-risque-minimal-de-cancer-du-foie-redefinir-cure-partielle","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/les-niveaux-dantigene-de-surface-a-faible-hepatite-b-signalent-un-risque-minimal-de-cancer-du-foie-redefinir-cure-partielle\/","title":{"rendered":"Les niveaux d’antig\u00e8ne de surface \u00e0 faible h\u00e9patite B signalent un risque minimal de cancer du foie, red\u00e9finir ‘cure partielle’"},"content":{"rendered":"
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Des chercheurs du National Taiwan University Hospital and Academia Sinica ont identifi\u00e9 un marqueur sanguin simple qui peut identifier de mani\u00e8re fiable les patients chroniques de l’h\u00e9patite B (CHB) \u00e0 risque n\u00e9gligeable de d\u00e9velopper un cancer du foie.<\/p>\n

L’\u00e9tude, publi\u00e9e dans Intestin<\/i>montre que les patients atteints d’antig\u00e8nes de surface de l’h\u00e9patite B (HBSAG) inf\u00e9rieurs \u00e0 100 UI \/ ml sont confront\u00e9s \u00e0 un risque annuel de carcinome h\u00e9patocellulaire (CHC) de seulement 0,08%, comparable \u00e0 la population g\u00e9n\u00e9rale.<\/p>\n

Les r\u00e9sultats proviennent de deux du monde’Les plus grandes cohortes du VHB, \u00e9radiquer-B et r\u00e9v\u00e9ler-HBV, avec plus de 2 600 patients CHB inactifs ont suivi pendant plus de 25 ans. La validation dans la cohorte NTUH-IMD a confirm\u00e9 que le seuil \u00e0 faible risque s’applique largement.<\/p>\n

Notamment, environ un tiers (37%) des patients CHB inactifs avaient du HBSAG <100 UI \/ ml, ce qui signifie que des millions dans le monde peuvent tomber dans cette cat\u00e9gorie \u00e0 risque ultra-faible.<\/p>\n

\u00ab\u00a0HbsAg <100 UI \/ ML identifie les patients avec ce que nous appelons un 'cure partielle' de l'h\u00e9patite B \", a d\u00e9clar\u00e9 le docteur Tai-Chung Tseng, auteur principal.\" Ces patients peuvent ne plus avoir besoin d'une surveillance de cancer du foie de routine, qui pourrait transformer des strat\u00e9gies de sant\u00e9 publique. \"<\/p>\n

\u00c0 l’\u00e9chelle mondiale, 254 millions de personnes vivent avec du CHB et plus d’un million de moules par an, principalement du HCC. Les protocoles de surveillance actuels sont co\u00fbteux et souvent contraignants, en particulier dans les contextes limit\u00e9es en ressources. En adoptant HBSAG <100 UI \/ ml comme r\u00e9f\u00e9rence pour le rem\u00e8de partiel, les cliniciens peuvent r\u00e9duire la surveillance chez les patients \u00e0 faible risque tout en concentrant des ressources sur les personnes \u00e0 risque plus \u00e9lev\u00e9.<\/p>\n

Les auteurs soulignent que ce seuil pourrait \u00e9galement servir de crit\u00e8re d’\u00e9valuation pratique pour les prochains essais de gu\u00e9rison du VHB, combler l’\u00e9cart entre la th\u00e9rapie antivirale actuelle et le rem\u00e8de fonctionnel.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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