{"id":9335,"date":"2025-09-11T09:59:31","date_gmt":"2025-09-11T07:59:31","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/desactiver-le-bouton-dauto-destruction-qui-provoque-des-dommages-pulmonaires-a-la-grippe\/"},"modified":"2025-09-11T09:59:34","modified_gmt":"2025-09-11T07:59:34","slug":"desactiver-le-bouton-dauto-destruction-qui-provoque-des-dommages-pulmonaires-a-la-grippe","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/desactiver-le-bouton-dauto-destruction-qui-provoque-des-dommages-pulmonaires-a-la-grippe\/","title":{"rendered":"D\u00e9sactiver le \u00abbouton d’auto-destruction\u00bb qui provoque des dommages pulmonaires \u00e0 la grippe"},"content":{"rendered":"
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La grippe (grippe) peut \u00eatre mortelle, mais la fa\u00e7on dont elle cause de graves dommages aux poumons a \u00e9t\u00e9 un myst\u00e8re – jusqu’\u00e0 maintenant.<\/p>\n

De nouvelles recherches ont identifi\u00e9 une prot\u00e9ine qui agit comme un \u00ab\u00a0bouton d’autodestruction\u00a0\u00bb dans les poumons, ouvrant la porte \u00e0 de nouveaux traitements qui combattent la maladie. L’\u00e9tude est publi\u00e9e dans la revue Mort et maladie cellulaire<\/i>.<\/p>\n

La grippe provoque jusqu’\u00e0 650 000 d\u00e9c\u00e8s dans le monde chaque ann\u00e9e et la grippe s\u00e9v\u00e8re peut entra\u00eener une hospitalisation, une insuffisance pulmonaire et des probl\u00e8mes de sant\u00e9 \u00e0 long terme, mais ce n’est pas le pire, selon la professeure agr\u00e9g\u00e9e Michelle Tate.<\/p>\n

Elle se sp\u00e9cialise dans la compr\u00e9hension de la fa\u00e7on dont l’hyperinflammation se d\u00e9veloppe dans les maladies respiratoires graves, et elle pr\u00e9vient que les options de traitement actuelles sont limit\u00e9es et que la r\u00e9sistance aux m\u00e9dicaments antiviraux augmente.<\/p>\n

R\u00e9duire les dommages pulmonaires de la grippe<\/h2>\n

\u00ab\u00a0Chaque ann\u00e9e, des milliers de personnes, en particulier des adultes de 65 ans et plus et celles dont le syst\u00e8me immunitaire affaibli, tombent gravement malades de la grippe\u00a0\u00bb, a d\u00e9clar\u00e9 A \/ Prof Tate. \u00ab\u00a0Nos r\u00e9sultats pourraient conduire \u00e0 de nouveaux m\u00e9dicaments qui r\u00e9duisent les l\u00e9sions pulmonaires et l’inflammation, aidant les gens \u00e0 r\u00e9cup\u00e9rer plus rapidement et \u00e0 r\u00e9duire le risque de d\u00e9c\u00e8s par grippe s\u00e9v\u00e8re.\u00a0\u00bb<\/p>\n

Alors, quelles sont ces r\u00e9sultats et pourquoi sont-ils importants?<\/p>\n

Travailler avec Ph.D. L’\u00e9tudiante, Sarah Rosli, A \/ Prof Tate a d\u00e9couvert une nouvelle fa\u00e7on dont le corps r\u00e9agit au virus de la grippe. \u00ab\u00a0Nous avons constat\u00e9 qu’une prot\u00e9ine appel\u00e9e Gasdermin E joue un r\u00f4le majeur dans la cause des dommages pulmonaires pendant la grippe. En supprimant cette prot\u00e9ine, nous avons pu r\u00e9duire l’inflammation et am\u00e9liorer la survie\u00a0\u00bb, a-t-elle d\u00e9clar\u00e9.<\/p>\n

\u00ab\u00a0Nous avons d\u00e9couvert que la gasdermin E agit comme un bouton\u00a0\u00bb autodestruct \u00ab\u00a0dans les cellules \u00e9pith\u00e9liales pulmonaires pendant l’infection, ce qui les a fait \u00e9clater et lib\u00e9rer des signaux inflammatoires.\u00a0\u00bb<\/p>\n

Elle a dit que les actions de cette prot\u00e9ine entra\u00eenaient plus de dommages tissulaires et aggravent la maladie.<\/p>\n

Une voie vers une grippe moins s\u00e9v\u00e8re<\/h2>\n

\u00ab\u00a0Lorsque nous avons supprim\u00e9 cette prot\u00e9ine, les poumons sont rest\u00e9s en meilleure sant\u00e9 et la grippe \u00e9tait moins grave. Cela ouvre des possibilit\u00e9s passionnantes pour de nouveaux traitements qui aident le corps \u00e0 lutter contre la grippe plus efficacement.\u00a0\u00bb<\/p>\n

Cette premi\u00e8re \u00e9tude mondiale montre qu’une prot\u00e9ine, la gasdermine E, est activ\u00e9e par plusieurs souches du virus de la grippe et joue un r\u00f4le central dans le d\u00e9clenchement de la mort des cellules \u00e9pith\u00e9liales et une inflammation incontr\u00f4l\u00e9e.<\/p>\n

\u00ab\u00a0En bloquant cette voie, nous avons pu r\u00e9duire l’inflammation et la r\u00e9plication virale, pointant une nouvelle fa\u00e7on de traiter la grippe s\u00e9v\u00e8re \u00e0 travers diff\u00e9rents types de virus\u00a0\u00bb, a d\u00e9clar\u00e9 Rosli.<\/p>\n

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La grippe (grippe) peut \u00eatre mortelle, mais la fa\u00e7on dont elle cause de graves dommages<\/p>\n","protected":false},"author":1,"featured_media":9336,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2120,6614,16,6613,2491,419,3461,1517,193],"class_list":["post-9335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-bouton","tag-dautodestruction","tag-des","tag-desactiver","tag-dommages","tag-grippe","tag-provoque","tag-pulmonaires","tag-qui","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nD\u00e9sactiver le \u00abbouton d'auto-destruction\u00bb qui provoque des dommages pulmonaires \u00e0 la grippe - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/desactiver-le-bouton-dauto-destruction-qui-provoque-des-dommages-pulmonaires-a-la-grippe\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9sactiver le \u00abbouton d'auto-destruction\u00bb qui provoque des dommages pulmonaires \u00e0 la grippe - 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