{"id":9128,"date":"2025-09-05T06:55:56","date_gmt":"2025-09-05T04:55:56","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/nouvel-antibiotique-pour-combattre-superbug-c-diff-savere-efficace-dans-les-essais-cliniques\/"},"modified":"2025-09-05T06:55:59","modified_gmt":"2025-09-05T04:55:59","slug":"nouvel-antibiotique-pour-combattre-superbug-c-diff-savere-efficace-dans-les-essais-cliniques","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/nouvel-antibiotique-pour-combattre-superbug-c-diff-savere-efficace-dans-les-essais-cliniques\/","title":{"rendered":"Nouvel antibiotique pour combattre Superbug C. Diff s’av\u00e8re efficace dans les essais cliniques"},"content":{"rendered":"
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Comme l’efficacit\u00e9 des antibiotiques destin\u00e9e \u00e0 combattre le Clostridioides Metfral Superbug difficile, ou C. Diff, Wanes, une \u00e9quipe de recherche \u00e0 l’Universit\u00e9 de Houston, les r\u00e9sultats positifs d’un nouvel antibiotique sur la sc\u00e8ne – vous-r\u00e9f.<\/p>\n

C. Diff est la principale cause de d\u00e9c\u00e8s du pays sous gastro-ent\u00e9rite, provoquant environ 453 000 infections chaque ann\u00e9e et 29 300 d\u00e9c\u00e8s. Il provoque une maladie gastro-intestinale allant de la diarrh\u00e9e et des douleurs abdominales au m\u00e9gacolon toxique, \u00e0 la septic\u00e9mie et \u00e0 la mort.<\/p>\n

Jusqu’\u00e0 pr\u00e9sent, les traitements de premi\u00e8re ligne de C. diff ont \u00e9t\u00e9 l’antibiotique vancomycine, avec un rem\u00e8de clinique soutenu de 42% \u00e0 71%, et la fidaxomicine \u00e0 67%.<\/p>\n

Et pourtant, un superbactif ne serait pas si mortel s’il n’\u00e9tait pas en mesure de survivre aux m\u00e9dicaments m\u00eames destin\u00e9s \u00e0 le d\u00e9truire.<\/p>\n

\u00ab\u00a0Vanco et Fidaxo sont associ\u00e9s \u00e0 une r\u00e9sistance aux antimicrobiens \u00e9mergente. La r\u00e9currence de l’infection par difficile est associ\u00e9e \u00e0 une mortalit\u00e9 accrue, \u00e0 une diminution de la qualit\u00e9 de vie et \u00e0 des co\u00fbts de soins de sant\u00e9 plus \u00e9lev\u00e9s. De nouveaux antibiotiques sont n\u00e9cessaires de toute urgence.\u00a0\u00bb a d\u00e9clar\u00e9 Kevin Garey, Robert L. Boblitt a d\u00fb le professeur de d\u00e9couverte de m\u00e9dicaments \u00e0 l’Universit\u00e9 de Houston College of Pharmacy et auteur principal sur les r\u00e9sultats r\u00e9cents des essais cliniques avec IBEZAPOLSTAT publi\u00e9 dans Le Microbe Lancet<\/i>.<\/p>\n

Les infections \u00e0 C. Diff reviennent souvent lorsque l’\u00e9quilibre naturel de l’intestin reste perturb\u00e9 – les bonnes bact\u00e9ries comme Bacillota, Bacteroidota et Actinomycetota sont r\u00e9duites, tandis que les types nocifs comme la pseudomonadota augmentent. Ces changements peuvent affaiblir les d\u00e9fenses de l’intestin, provoquant une perte du type de bact\u00e9ries qui aide \u00e0 d\u00e9composer les acides biliaires. Lorsque cela se produit, les bact\u00e9ries nocives peuvent facilement prendre le relais.<\/p>\n

\u00ab\u00a0Le m\u00e9canisme d’action d’Ibezapolstat aide \u00e0 restaurer le microbiote sain qui provoque une r\u00e9cidive de C. Diff\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur principal de l’\u00e9tude Taryn A. Eubank, professeur adjoint de recherche de pratique en pharmacie et de recherche translationnelle \u00e0 UH.<\/p>\n

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Entrez IBEZAPOLSTAT<\/h2>\n

Ibezapolstat a une fa\u00e7on de travailler qui tue les bact\u00e9ries C. difficile nocives sans nuire aux bonnes bact\u00e9ries dans l’intestin qui prot\u00e8gent contre les infections \u00e0 C. diff.<\/p>\n

\u00ab\u00a0Une \u00e9tude randomis\u00e9e, en double aveugle et contr\u00f4l\u00e9e active, a montr\u00e9 des taux \u00e9lev\u00e9s de gu\u00e9rison clinique initial chez les participants trait\u00e9s avec IBEZAPOLSTAT, sans r\u00e9cidive\u00a0\u00bb, rapporte Garey.<\/p>\n

\u00ab\u00a0Ibezapolstat s’est av\u00e9r\u00e9 \u00eatre s\u00fbr, bien tol\u00e9r\u00e9 et a \u00e9t\u00e9 associ\u00e9 \u00e0 la pr\u00e9servation de bact\u00e9ries cl\u00e9s favorisant la sant\u00e9 responsables de l’hom\u00e9ostasie des acides biliaires, un composant cl\u00e9 pour pr\u00e9venir l’infection r\u00e9currente de C. difficile.\u00a0\u00bb<\/p>\n

EUBANK a ajout\u00e9: \u00ab\u00a0Cela aide \u00e0 confirmer les importantes propri\u00e9t\u00e9s de r\u00e9cidive de difficult\u00e9 anti-C d’IbezapolStat.\u00a0\u00bb<\/p>\n

IbezapolStat est d\u00e9velopp\u00e9 par Acurx Pharmaceuticals progressant vers des essais cliniques de phase III. L’\u00e9tude a \u00e9t\u00e9 men\u00e9e dans 15 centres, principalement des cliniques ambulatoires et des h\u00f4pitaux aux \u00c9tats-Unis. Les participants \u00e9taient \u00e2g\u00e9s de 18 \u00e0 90 ans, avec diarrh\u00e9e et un diagnostic confirm\u00e9 d’une infection Colide l\u00e9g\u00e8re ou mod\u00e9r\u00e9e.<\/p>\n

\u00ab\u00a0Les r\u00e9sultats de notre \u00e9tude soutiennent le d\u00e9veloppement clinique de l’iBezapolstat dans des essais cliniques de phase III et une utilisation \u00e9ventuelle chez nos patients\u00a0\u00bb, a d\u00e9clar\u00e9 Garey.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Comme l’efficacit\u00e9 des antibiotiques destin\u00e9e \u00e0 combattre le Clostridioides Metfral Superbug difficile, ou C. Diff,<\/p>\n","protected":false},"author":1,"featured_media":9129,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3459,443,1682,44,4729,206,442,49,1760,8,1639,6526],"class_list":["post-9128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-antibiotique","tag-cliniques","tag-combattre","tag-dans","tag-diff","tag-efficace","tag-essais","tag-les","tag-nouvel","tag-pour","tag-savere","tag-superbug","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nNouvel antibiotique pour combattre Superbug C. 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