{"id":8959,"date":"2025-08-28T18:56:00","date_gmt":"2025-08-28T16:56:00","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/comprendre-comment-le-cytomegalovirus-humain-manipule-notre-adn\/"},"modified":"2025-08-28T18:56:02","modified_gmt":"2025-08-28T16:56:02","slug":"comprendre-comment-le-cytomegalovirus-humain-manipule-notre-adn","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/comprendre-comment-le-cytomegalovirus-humain-manipule-notre-adn\/","title":{"rendered":"Comprendre comment le cytom\u00e9galovirus humain manipule notre ADN"},"content":{"rendered":"
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Selon une nouvelle \u00e9tude publi\u00e9e dans une nouvelle \u00e9tude publi\u00e9e Communications de la nature<\/i>.<\/p>\n

Le cytom\u00e9galovirus humain (HCMV) est un virus commun qui infecte les personnes de tous \u00e2ges. Aux \u00c9tats-Unis, pr\u00e8s de 1 enfant sur 3 est d\u00e9j\u00e0 infect\u00e9 par le CMV \u00e0 l’\u00e2ge de 5 ans et plus de la moiti\u00e9 des adultes ont \u00e9t\u00e9 infect\u00e9s par le HCMV \u00e0 l’\u00e2ge de 40 ans, selon les estimations des Centers for Disease Control and Prevention. Alors que la plupart des personnes atteintes de HCMV ne pr\u00e9sentent aucun sympt\u00f4me, le virus peut d\u00e9clencher des probl\u00e8mes de cerveau, de foie, de rate, de poumons et de croissance.<\/p>\n

\u00ab\u00a0Le cytom\u00e9galovirus humain est un virus r\u00e9pandu associ\u00e9 aux malformations cong\u00e9nitales cong\u00e9nitales et \u00e0 plusieurs autres conditions graves\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur principal de l’\u00e9tude Derek Walsh, Ph.D., professeur de microbiologie-immunologie. \u00ab\u00a0Il a \u00e9galement un cycle de r\u00e9plication tr\u00e8s inhabituel qui s’\u00e9tend sur 5 \u00e0 10 jours, au cours de laquelle il remod\u00e8le largement la cellule.\u00a0\u00bb<\/p>\n

Pour mieux comprendre comment le virus remod\u00e8le les cellules infect\u00e9es, Walsh et ses collaborateurs ont utilis\u00e9 des outils g\u00e9nomiques de pointe pour cartographier comment le HCMV manipule l’organisation tridimensionnelle des chromosomes. Gr\u00e2ce \u00e0 la capture de conformation de la chromatine (Hi-C) et \u00e0 la transcriptomique naissante, ils ont d\u00e9couvert que le virus provoque une d\u00e9sorganisation g\u00e9n\u00e9ralis\u00e9e des interactions de la chromatine et de la formation de compartiments, tout en induit une expression g\u00e8ne anormale.<\/p>\n

Ce remodelage comprend la cr\u00e9ation d’un nouveau centre organisant des microtubules qui fait pivoter le noyau, selon l’\u00e9tude.<\/p>\n

\u00ab\u00a0Dans des recherches ant\u00e9rieures, nous avons constat\u00e9 que le virus le fait pour s\u00e9parer spatialement la chromatine de l’h\u00f4te des centres de r\u00e9plication de l’ADN viral\u00a0\u00bb, a d\u00e9clar\u00e9 Walsh. \u00ab\u00a0Mais nous ne savions toujours pas ce qui se passait \u00e0 un niveau g\u00e9n\u00e9tique.\u00a0\u00bb<\/p>\n

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Ensuite, les scientifiques ont analys\u00e9 le comportement du virus dans les cellules humaines cultiv\u00e9es apr\u00e8s l’infection. Dirig\u00e9e par Celeste Rosencrance, un \u00e9tudiant du programme d’\u00e9tudes sup\u00e9rieures de Driskill dans la vie (DGP) qui a \u00e9t\u00e9 le premier auteur de l’\u00e9tude, l’analyse a r\u00e9v\u00e9l\u00e9 que le virus pr\u00e9f\u00e8re se reproduire dans les r\u00e9gions euchromatiques – des axes du g\u00e9nome qui sont moins des et plus actifs transcriptionnellement.<\/p>\n

\u00ab\u00a0Les forces de tir des microtubules aident \u00e0 d\u00e9placer la chromatine plus dense \u00e0 l’\u00e9cart pour optimiser comment le virus cr\u00e9e des espaces de r\u00e9plication nucl\u00e9aire\u00a0\u00bb, a d\u00e9clar\u00e9 Walsh.<\/p>\n

Bien que ces forces m\u00e9caniques ne semblent pas influencer la perturbation plus large de la chromatine ou du contr\u00f4le transcriptionnel, elles r\u00e9gulent les interactions \u00e0 plus petite \u00e9chelle, en particulier la fa\u00e7on dont l’ADN viral interagit avec la chromatine h\u00f4te.<\/p>\n

Les nouvelles id\u00e9es approfondissent non seulement la compr\u00e9hension scientifique de l’impact du HCMV sur l’architecture cellulaire et l’expression des g\u00e8nes, mais ouvrent \u00e9galement de nouvelles avenues pour les strat\u00e9gies antivirales ciblant la capacit\u00e9 du virus \u00e0 rec\u00e2bler physiquement et g\u00e9n\u00e9tiquement les cellules h\u00f4tes.<\/p>\n

\u00ab\u00a0Les gens ne consid\u00e8rent souvent pas que le noyau est comme une enclume\u00a0\u00bb, a d\u00e9clar\u00e9 Walsh. \u00ab\u00a0En tant que plus grand organite de la cellule, c’est un obstacle majeur \u00e0 la migration cellulaire. Nous apprenons que le virus manipule exquis ces processus.\u00a0\u00bb<\/p>\n

Pour l’avenir, le laboratoire de Walsh explorera comment la m\u00e9canique des microtubules contribuera au mouvement nucl\u00e9aire au cours des stades ult\u00e9rieurs de l’infection \u00e0 mesure que les cellules commencent \u00e0 migrer.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Selon une nouvelle \u00e9tude publi\u00e9e dans une nouvelle \u00e9tude publi\u00e9e Communications de la nature. 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