{"id":8943,"date":"2025-08-28T02:55:57","date_gmt":"2025-08-28T00:55:57","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/le-ciblage-des-glycanes-a-enveloppe-virale-offre-une-voie-prometteuse-vers-le-premier-antiviral-a-large-spectre-mondial\/"},"modified":"2025-08-28T02:55:57","modified_gmt":"2025-08-28T00:55:57","slug":"le-ciblage-des-glycanes-a-enveloppe-virale-offre-une-voie-prometteuse-vers-le-premier-antiviral-a-large-spectre-mondial","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/le-ciblage-des-glycanes-a-enveloppe-virale-offre-une-voie-prometteuse-vers-le-premier-antiviral-a-large-spectre-mondial\/","title":{"rendered":"Le ciblage des glycanes \u00e0 enveloppe virale offre une voie prometteuse vers le premier antiviral \u00e0 large spectre mondial"},"content":{"rendered":"
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Des chercheurs de la Nanoscience Initiative de l’Advanced Science Research Center du CUNY Graduate Center (CUNY ASRC) ont fait une perc\u00e9e dans la lutte contre les maladies virales.<\/p>\n

Leur \u00e9tude, publi\u00e9e dans la revue Avanc\u00e9es scientifiques<\/i>offre une voie prometteuse vers le d\u00e9veloppement du premier antiviral \u00e0 large spectre au monde (BSA), qui pourrait \u00eatre d\u00e9ploy\u00e9 contre un large \u00e9ventail de virus mortels, y compris les futures menaces pand\u00e9miques.<\/p>\n

Contrairement aux infections bact\u00e9riennes, que les m\u00e9decins commencent souvent \u00e0 traiter imm\u00e9diatement avec des antibiotiques \u00e0 large spectre alors qu’ils travaillent pour d\u00e9terminer les bact\u00e9ries sp\u00e9cifiques, les infections virales sont trait\u00e9es avec des antiviraux, qui sont cibl\u00e9s de peu et efficaces contre un petit ensemble de virus apparent\u00e9s.<\/p>\n

\u00ab\u00a0Ce manque de traitements peut laisser des populations vuln\u00e9rables pendant des ann\u00e9es, tandis que les vaccins et les th\u00e9rapies sont en cours d’\u00e9laboration\u00a0\u00bb, a d\u00e9clar\u00e9 l’investigateur principal Adam Braunschweig, professeur d’initiative nanoscience chez CUNY ASRC et professeur de chimie et de biochimie au Hunter College.<\/p>\n

L’\u00e9quipe de Braunschweig a d\u00e9cid\u00e9 de relever ce d\u00e9fi mondial de sant\u00e9 en ciblant une caract\u00e9ristique partag\u00e9e trouv\u00e9e \u00e0 la surface de nombreux virus: les glycanes de l’enveloppe virale – des mol\u00e9cules de souille qui sont structurellement conserv\u00e9es dans des familles virales non li\u00e9es. Ces caract\u00e9ristiques largement partag\u00e9es sont jusqu’\u00e0 pr\u00e9sent rest\u00e9es une cible inexploit\u00e9e pour le d\u00e9veloppement de m\u00e9dicaments antiviraux.<\/p>\n

Les chercheurs ont s\u00e9lectionn\u00e9 57 r\u00e9cepteurs de glucides synth\u00e9tiques (SCR), qui sont de petites mol\u00e9cules con\u00e7ues pour se lier aux glycanes viraux. Ils ont identifi\u00e9 quatre compos\u00e9s de plomb qui ont r\u00e9ussi \u00e0 bloquer l’infection de sept virus diff\u00e9rents dans cinq familles non apparent\u00e9es, y compris certains des agents pathog\u00e8nes les plus dangereux du monde: Ebola, Marburg, Nipah, Hendra, SARS-CoV-1 et SARS-CoV-2.<\/p>\n

Dans un test critique, l’un des compos\u00e9s SCR du plomb a \u00e9t\u00e9 utilis\u00e9 pour traiter les souris infect\u00e9es par SARS-COV-2. Quatre-vingt-dix pour cent des souris recevant le SCR ont surv\u00e9cu, par rapport \u00e0 aucun dans le groupe t\u00e9moin. Une analyse plus approfondie a confirm\u00e9 que les compos\u00e9s fonctionnent en se liant aux glycanes d’enveloppe virale – un nouveau m\u00e9canisme d’action avec des applications potentielles non seulement pour les maladies infectieuses mais aussi pour le cancer et les troubles immunitaires.<\/p>\n

\u00ab\u00a0C’est le genre d’outil antiviral dont le monde a besoin de toute urgence\u00a0\u00bb, a d\u00e9clar\u00e9 Braunschweig. \u00ab\u00a0Si un nouveau virus \u00e9merge demain, nous n’avons actuellement rien \u00e0 d\u00e9ployer. Ces compos\u00e9s offrent le potentiel d’\u00eatre cette premi\u00e8re ligne de d\u00e9fense.\u00a0\u00bb<\/p>\n

La prochaine phase des recherches de l’\u00e9quipe se concentrera sur l’avancement des compos\u00e9s les plus prometteurs dans les essais cliniques.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de la Nanoscience Initiative de l’Advanced Science Research Center du CUNY Graduate Center<\/p>\n","protected":false},"author":1,"featured_media":4156,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3601,6452,16,6454,6453,3418,5618,1035,322,1790,786,47,126,1197,188],"class_list":["post-8943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-antiviral","tag-ciblage","tag-des","tag-enveloppe","tag-glycanes","tag-large","tag-mondial","tag-offre","tag-premier","tag-prometteuse","tag-spectre","tag-une","tag-vers","tag-virale","tag-voie","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLe ciblage des glycanes \u00e0 enveloppe virale offre une voie prometteuse vers le premier antiviral \u00e0 large spectre mondial - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/le-ciblage-des-glycanes-a-enveloppe-virale-offre-une-voie-prometteuse-vers-le-premier-antiviral-a-large-spectre-mondial\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le ciblage des glycanes \u00e0 enveloppe virale offre une voie prometteuse vers le premier antiviral \u00e0 large spectre mondial - 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