{"id":8710,"date":"2025-08-19T02:58:30","date_gmt":"2025-08-19T00:58:30","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/le-sequencage-des-anticorps-circulants-dun-enfant-expose-au-paludisme-fournit-un-nouvel-apercu-de-limmunite\/"},"modified":"2025-08-19T02:58:33","modified_gmt":"2025-08-19T00:58:33","slug":"le-sequencage-des-anticorps-circulants-dun-enfant-expose-au-paludisme-fournit-un-nouvel-apercu-de-limmunite","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/le-sequencage-des-anticorps-circulants-dun-enfant-expose-au-paludisme-fournit-un-nouvel-apercu-de-limmunite\/","title":{"rendered":"Le s\u00e9quen\u00e7age des anticorps circulants d’un enfant expos\u00e9 au paludisme fournit un nouvel aper\u00e7u de l’immunit\u00e9"},"content":{"rendered":"
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Dans un premier scientifique, les chercheurs ont d\u00e9cod\u00e9 un anticorps naturellement acquis directement du sang d’un enfant expos\u00e9 au paludisme. En utilisant une spectrom\u00e9trie de masse avanc\u00e9e, l’\u00e9quipe a identifi\u00e9 un anticorps qui bloque une interaction critique entre le parasite Plasmodium falciparum et les vaisseaux sanguins humains – un pas au c\u0153ur du d\u00e9veloppement d’un paludisme s\u00e9v\u00e8re.<\/p>\n

Le paludisme, caus\u00e9 par Plasmodium falciparum, reste une menace majeure de sant\u00e9 mondiale, affirmant que 600 000 vies par an, principalement de jeunes enfants en Afrique subsaharienne. L’immunit\u00e9 au paludisme s\u00e9v\u00e8re se d\u00e9veloppe apr\u00e8s des infections r\u00e9p\u00e9t\u00e9es et est m\u00e9di\u00e9e par des anticorps bloquant les prot\u00e9ines d’adh\u00e9sion PFEMP1 hautement diversifi\u00e9es du parasite de la liaison au r\u00e9cepteur de la prot\u00e9ine endoth\u00e9liale humaine (EPCR) sur les parois des vaisseaux sanguins.<\/p>\n

Dans l’\u00e9tude collaborative, des chercheurs de l’Institut national de recherche m\u00e9dicale en Tanzanie et de l’Universit\u00e9 de Copenhague ont identifi\u00e9 que les donateurs atteints de plasma immunitaire sont en mesure d’emp\u00eacher de nombreuses variantes de PFEMP1 diverses de se lier \u00e0 l’EPCR. Le document est publi\u00e9 dans la revue Actes de l’Acad\u00e9mie nationale des sciences<\/i>.<\/p>\n

Les chercheurs ont utilis\u00e9 la plate-forme de d\u00e9couverte des anticorps de repab pour d\u00e9couvrir la s\u00e9quence d’acides amin\u00e9s d’un anticorps monoclonal avec une large activit\u00e9 inhibitrice contre diverses variantes PFEMP1. C’est la premi\u00e8re fois que une spectrom\u00e9trie de masse est appliqu\u00e9e pour identifier un anticorps plasmatique fonctionnel d\u00e9velopp\u00e9 naturellement apr\u00e8s l’infection.<\/p>\n

L’analyse structurelle des prot\u00e9ines, r\u00e9alis\u00e9e avec des chercheurs du Scripps Research Institute en Californie, a r\u00e9v\u00e9l\u00e9 comment cet anticorps largement neutralisant se lie aux r\u00e9sidus conserv\u00e9s \u00e0 travers diff\u00e9rentes variantes PFEMP1 pour bloquer l’adh\u00e9sion parasite.<\/p>\n

\u00ab\u00a0En s\u00e9quen\u00e7ant un anticorps acquis naturellement circulant dans le sang et en voyant exactement comment il se lie, nous gagnons un aper\u00e7u pr\u00e9cieux de la r\u00e9ponse de protection contre les anticorps contre le paludisme\u00a0\u00bb, explique Louise Turner, Center for Translational Medicine and Parasitology, Universit\u00e9 de Copenhague.<\/p>\n

\u00ab\u00a0Nous pouvons d\u00e9sormais identifier des anticorps inhibiteurs fonctionnellement significatifs directement des individus naturellement expos\u00e9s \u00e0 l’infection. Cela fournit un moyen puissant d’\u00e9tudier les r\u00e9ponses d’anticorps acquises naturellement et de g\u00e9n\u00e9rer des pistes pour notre recherche sur les vaccins\u00a0\u00bb, explique le professeur Thomas Lavstsen, Center for Translational Medicine and Parasitology, University of Copenhagen.<\/p>\n

L’\u00e9tude a \u00e9t\u00e9 r\u00e9alis\u00e9e en collaboration entre le Center for Translational Medicine and Parasitology, D\u00e9partement d’immunologie et de microbiologie \u00e0 l’Universit\u00e9 de Copenhague et du D\u00e9partement des maladies infectieuses, Rigshospitalmet, Danemark; L’Institut national de recherche m\u00e9dicale, Tanzanie; Rapid Novor, Canada; Et le Scripps Research Institute California, \u00c9tats-Unis<\/p>\n

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