{"id":8681,"date":"2025-08-17T10:57:34","date_gmt":"2025-08-17T08:57:34","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/le-medicament-a-la-fibrose-pulmonaire-surpasse-les-steroides-dans-le-modele-preclinique\/"},"modified":"2025-08-17T10:57:36","modified_gmt":"2025-08-17T08:57:36","slug":"le-medicament-a-la-fibrose-pulmonaire-surpasse-les-steroides-dans-le-modele-preclinique","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/le-medicament-a-la-fibrose-pulmonaire-surpasse-les-steroides-dans-le-modele-preclinique\/","title":{"rendered":"Le m\u00e9dicament \u00e0 la fibrose pulmonaire surpasse les st\u00e9ro\u00efdes dans le mod\u00e8le pr\u00e9clinique"},"content":{"rendered":"
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Les chercheurs ont trouv\u00e9 une perc\u00e9e prometteuse du traitement pour la maladie pulmonaire obstructive chronique (MPOC) qui \u00e9vite de nombreux inconv\u00e9nients des m\u00e9dicaments actuels, et il est venu d’un endroit inattendu.<\/p>\n

La MPOC est un terme parapluie pour un certain nombre de conditions pulmonaires, notamment l’emphys\u00e8me et la bronchite chronique. La maladie rend la respiration difficile, est souvent compliqu\u00e9e par des attaques soudaines graves et s’aggrave g\u00e9n\u00e9ralement avec le temps.<\/p>\n

En Australie, il affecte environ 2 millions de personnes et constitue une cause importante de morbidit\u00e9 et de mortalit\u00e9, en particulier chez les personnes de plus de 40 ans.<\/p>\n

D\u00e9sormais, des \u00e9tudes au Hudson Institute of Medical Research, en collaboration avec Monash Health et le Monash Biomedicine Discovery Institute, ont constat\u00e9 qu’un m\u00e9dicament couramment utilis\u00e9 pour traiter la fibrose pulmonaire pourrait \u00e9galement \u00eatre id\u00e9al pour surmonter les probl\u00e8mes cl\u00e9s associ\u00e9s aux traitements actuels de la BPCO.<\/p>\n

Le traitement de la MPOC n\u00e9cessite souvent des st\u00e9ro\u00efdes<\/h2>\n

Le Dr Belinda Thomas du groupe de recherche respiratoire et pulmonaire a d\u00e9clar\u00e9 que la norme de soins actuelle pour la MPOC comprend g\u00e9n\u00e9ralement des st\u00e9ro\u00efdes, des m\u00e9dicaments qui sont bons pour r\u00e9duire l’inflammation. Cependant, des attaques soudaines de MPOC (appel\u00e9es exacerbations) sont g\u00e9n\u00e9ralement caus\u00e9es par des virus et des st\u00e9ro\u00efdes encouragent leur r\u00e9plication, aggravant les choses.<\/p>\n

Les st\u00e9ro\u00efdes peuvent r\u00e9soudre un probl\u00e8me (inflammation) – mais en provoquer un autre.<\/p>\n

L’\u00e9quipe du Hudson Institute of Medical Research a utilis\u00e9 un mod\u00e8le pr\u00e9clinique de laboratoire qui imite la MPOC pour tester le m\u00e9dicament Pirf\u00e9nidone et les r\u00e9sultats \u00e9taient prometteurs.<\/p>\n

\u00ab\u00a0Par rapport aux st\u00e9ro\u00efdes, la pirf\u00e9nidone a r\u00e9duit la gravit\u00e9 de la maladie, abaissant \u00e0 la fois la r\u00e9plication du virus et l’inflammation des voies respiratoires, sans r\u00e9duire la r\u00e9ponse immunitaire, ce que font les st\u00e9ro\u00efdes\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Thomas.<\/p>\n

\u00ab\u00a0Les st\u00e9ro\u00efdes sont vraiment remplis d’effets n\u00e9gatifs, mais il n’y a rien pour les remplacer jusqu’\u00e0 pr\u00e9sent et nous pensons que la pirf\u00e9nidone est une option passionnante.\u00a0\u00bb<\/p>\n

Les avantages des st\u00e9ro\u00efdes ont un prix<\/h2>\n

Professeur de m\u00e9decine respiratoire et de directeur \u00e9m\u00e9rite, Monash Lung Sleep Allergy & Immunology, Philip Bardin, qui a supervis\u00e9 la recherche, a d\u00e9clar\u00e9 que les effets secondaires des st\u00e9ro\u00efdes peuvent \u00eatre horribles – les diab\u00e9tiques, l’hypertension, les maladies cardiaques, l’ost\u00e9oporose, l’ob\u00e9sit\u00e9, les changements cutan\u00e9s et les effets sur le sommeil.<\/p>\n

\u00ab\u00a0Ils sont merveilleux pour l’inflammation, mais cela a un prix\u00a0\u00bb, a-t-il d\u00e9clar\u00e9.<\/p>\n

\u00ab\u00a0La pirf\u00e9nidone a eu l’effet inverse aux st\u00e9ro\u00efdes, d’une certaine mani\u00e8re, car il a att\u00e9nu\u00e9 l’infection et il a aid\u00e9 \u00e0 l’inflammation, tandis qu’avec les st\u00e9ro\u00efdes, l’infection a \u00e9t\u00e9 aggrav\u00e9e, bien qu’elle aie quelque peu aid\u00e9 \u00e0 l’inflammation.<\/p>\n

\u00ab\u00a0Le grand avantage si ce traitement est traduit dans la clinique est que les gens pourraient sortir des st\u00e9ro\u00efdes\u00a0\u00bb, a-t-il d\u00e9clar\u00e9. \u00ab\u00a0Les effets n\u00e9fastes des st\u00e9ro\u00efdes s’accumulent avec le temps, de sorte qu’\u00e0 l’\u00e2ge de 60 ans, de nombreuses personnes commencent \u00e0 avoir des effets secondaires graves tels que les maladies cardiaques, l’hypertension, le diab\u00e8te, les probl\u00e8mes de peau et l’ost\u00e9oporose.\u00a0\u00bb<\/p>\n

La pirf\u00e9nidone est enregistr\u00e9e pour \u00eatre utilis\u00e9e dans la fibrose pulmonaire idiopathique en Australie et dans le monde.<\/p>\n

Le professeur Bardin, le Dr Thomas et l’\u00e9quipe ont maintenant publi\u00e9 leurs r\u00e9sultats dans le Journal am\u00e9ricain de cellules respiratoires et de biologie mol\u00e9culaire<\/i>et la recherche a \u00e9galement \u00e9t\u00e9 soulign\u00e9e dans un commentaire \u00e9ditorial dans La m\u00e9decine respiratoire de Lancet<\/i>.<\/p>\n

\u00ab\u00a0Nous avons un mod\u00e8le pr\u00e9clinique robuste montrant que cela fonctionne et qu’il y aura probablement beaucoup d’int\u00e9r\u00eat \u00e0 r\u00e9utiliser la pirf\u00e9nidone dans la MPOC.\u00a0\u00bb Le Dr Thomas a d\u00e9clar\u00e9.<\/p>\n

\u00ab\u00a0Les st\u00e9ro\u00efdes sont couramment utilis\u00e9s et les gens acceptent simplement le fait qu’ils ont toutes ces limites, car les gens ne pensent pas qu’il y a autre chose. La pirf\u00e9nidone se cachait vraiment \u00e0 la vue – les gens \u00e9taient ravis qu’il arr\u00eatait ou ralentissait la fibrose pulmonaire, mais jusqu’\u00e0 pr\u00e9sent, personne n’avait pr\u00e9vu qu’il pourrait avoir cet important avantage suppl\u00e9mentaire.\u00a0\u00bb<\/p>\n

\u00ab\u00a0Il peut emp\u00eacher et traiter les fus\u00e9es de MPOC, l’\u00e9v\u00e9nement qui peut entra\u00eener une mort pr\u00e9matur\u00e9e dans la MPOC – lorsque les gens obtiennent de graves infections, c’est quand ils peuvent mourir.\u00a0\u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Les chercheurs ont trouv\u00e9 une perc\u00e9e prometteuse du traitement pour la maladie pulmonaire obstructive chronique<\/p>\n","protected":false},"author":1,"featured_media":8682,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[44,654,49,1046,1047,6329,2276,80,5586],"class_list":["post-8681","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-dans","tag-fibrose","tag-les","tag-medicament","tag-modele","tag-preclinique","tag-pulmonaire","tag-steroides","tag-surpasse","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLe m\u00e9dicament \u00e0 la fibrose pulmonaire surpasse les st\u00e9ro\u00efdes dans le mod\u00e8le pr\u00e9clinique - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/le-medicament-a-la-fibrose-pulmonaire-surpasse-les-steroides-dans-le-modele-preclinique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le m\u00e9dicament \u00e0 la fibrose pulmonaire surpasse les st\u00e9ro\u00efdes dans le mod\u00e8le pr\u00e9clinique - 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