{"id":8534,"date":"2025-08-10T10:55:53","date_gmt":"2025-08-10T08:55:53","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/"},"modified":"2025-08-10T10:55:53","modified_gmt":"2025-08-10T08:55:53","slug":"lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/","title":{"rendered":"L’activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d’initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche"},"content":{"rendered":"
\n
\n
\n
\n<\/figure><\/div>\n<\/div>\n

Un groupe dirig\u00e9 par le D\u00e9partement de biologie cellulaire du Renue Restney Research Center, Universit\u00e9 de Niigata, a r\u00e9v\u00e9l\u00e9 qu’une activit\u00e9 \u00e9lev\u00e9e de CDC42 est un \u00e9v\u00e9nement d’initiation essentiel menant \u00e0 la prot\u00e9inurie et a propos\u00e9 que la suppression de l’activit\u00e9 du CDC42 pourrait \u00eatre une th\u00e9rapie prometteuse pour le syndrome n\u00e9phrotique. Leur article est publi\u00e9 dans le Journal de l’American Society of Nephrology<\/i>.<\/p>\n

Le glom\u00e9rule est une unit\u00e9 de filtration du rein, et la paroi capillaire glom\u00e9rulaire fonctionne comme une barri\u00e8re, emp\u00eachant la fuite de la prot\u00e9ine plasmatique dans l’urine.<\/p>\n

La prot\u00e9inurie est un sympt\u00f4me clinique montrant un dysfonctionnement de la barri\u00e8re de la paroi capillaire glom\u00e9rulaire, et est un facteur aggravant conduisant \u00e0 une insuffisance r\u00e9nale. La prot\u00e9inurie serait un facteur de risque de maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires.<\/p>\n

Les cellules \u00e9pith\u00e9liales glom\u00e9rulaires (podocytes) sont situ\u00e9es dans la couche externe de la paroi capillaire glom\u00e9rulaire et poss\u00e8dent des processus uniques appel\u00e9s processus de pied. Les processus des pieds voisins sont pont\u00e9s par le diaphragme \u00e0 fente.<\/p>\n

Il est admis que le diaphragme \u00e0 fente fonctionne comme une barri\u00e8re finale emp\u00eachant la prot\u00e9inurie. Des \u00e9tudes cliniques r\u00e9centes ont rapport\u00e9 que les principales parties du syndrome n\u00e9phrotique sont caus\u00e9es par une auto-anticorps contre la n\u00e9phrine, un composant cl\u00e9 du diaphragme de la fente.<\/p>\n

Un groupe de l’Universit\u00e9 Niigata a analys\u00e9 les voies de signalisation dans les podocytes apr\u00e8s stimulation par un anticorps anti-n\u00e9phrine. L’\u00e9tude a r\u00e9v\u00e9l\u00e9 que l’\u00e9phrine-B1 dans le diaphragme \u00e0 fente interagissait avec la n\u00e9phrine et le par6, et que l’anticorps anti-n\u00e9phrine a provoqu\u00e9 les phosphorylations de la n\u00e9phrine et de l’\u00e9phrine-B12+<\/sup> mani\u00e8re d\u00e9pendante de l’afflux.<\/p>\n

L’\u00e9phrine-B1 phosphoryl\u00e9e a \u00e9t\u00e9 dissoci\u00e9e de la n\u00e9phrine et \u00e9galement de PAR6, et le PAR6 est venu interagir avec CDC42.<\/p>\n

La liaison de l’activit\u00e9 CDC42 favoris\u00e9e par6. Une activit\u00e9 \u00e9lev\u00e9e de Cdc42 a favoris\u00e9 l’activit\u00e9 de la calcineurine, l’escargot activ\u00e9, un facteur de transcription et une diminution de l’expression de l’ARNm de la n\u00e9phrine, de l’\u00e9phrine-B1 et d’autres mol\u00e9cules fonctionnelles du diaphragme de la fente.<\/p>\n

L’expression alt\u00e9r\u00e9e des mol\u00e9cules fonctionnelles a induit la perte de la fonction de barri\u00e8re du diaphragme de la fente, ce qui conduit \u00e0 la prot\u00e9inurie. L’\u00e9tude a \u00e9galement montr\u00e9 qu’un inhibiteur de CDC42 a restaur\u00e9 l’expression des mol\u00e9cules fonctionnelles du diaphragme \u00e0 fente.<\/p>\n

Les chercheurs soutiennent que la r\u00e9gulation de l’activit\u00e9 du CDC42 pourrait \u00eatre une th\u00e9rapie prometteuse pour le syndrome n\u00e9phrotique.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Un groupe dirig\u00e9 par le D\u00e9partement de biologie cellulaire du Renue Restney Research Center, Universit\u00e9<\/p>\n","protected":false},"author":1,"featured_media":8535,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[6263,666,6266,6265,963,223,6264,3369,6267,499,157],"class_list":["post-8534","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-cdc42","tag-cle","tag-conduisant","tag-dinitiation","tag-elevee","tag-est","tag-evenement","tag-lactivite","tag-proteinurie","tag-recherche","tag-revele","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nL'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"Un groupe dirig\u00e9 par le D\u00e9partement de biologie cellulaire du Renue Restney Research Center, Universit\u00e9\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\" \/>\n<meta property=\"og:site_name\" content=\"RVH-Synergie\" \/>\n<meta property=\"article:published_time\" content=\"2025-08-10T08:55:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Charles Martinez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Charles Martinez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\"},\"author\":{\"name\":\"Charles Martinez\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\"},\"headline\":\"L’activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d’initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche\",\"datePublished\":\"2025-08-10T08:55:53+00:00\",\"dateModified\":\"2025-08-10T08:55:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\"},\"wordCount\":493,\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg\",\"keywords\":[\"CDC42\",\"cl\u00e9\",\"conduisant\",\"dinitiation\",\"\u00e9lev\u00e9e\",\"est\",\"\u00e9v\u00e9nement\",\"lactivit\u00e9\",\"prot\u00e9inurie\",\"recherche\",\"r\u00e9v\u00e8le\"],\"articleSection\":[\"Les maladies\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\",\"name\":\"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche - RVH-Synergie.org\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg\",\"datePublished\":\"2025-08-10T08:55:53+00:00\",\"dateModified\":\"2025-08-10T08:55:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg\",\"width\":1280,\"height\":720,\"caption\":\"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/rvh-synergie.org\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"L’activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d’initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"name\":\"RVH-Synergie.org\",\"description\":\"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.\",\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\",\"name\":\"RVH-Synergie.org\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"width\":512,\"height\":512,\"caption\":\"RVH-Synergie.org\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\",\"name\":\"Charles Martinez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"caption\":\"Charles Martinez\"},\"description\":\"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.\",\"sameAs\":[\"https:\/\/rvh-synergie.org\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche - RVH-Synergie.org","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/","og_locale":"fr_FR","og_type":"article","og_title":"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche - RVH-Synergie.org","og_description":"Un groupe dirig\u00e9 par le D\u00e9partement de biologie cellulaire du Renue Restney Research Center, Universit\u00e9","og_url":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/","og_site_name":"RVH-Synergie","article_published_time":"2025-08-10T08:55:53+00:00","og_image":[{"width":1280,"height":720,"url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg","type":"image\/jpeg"}],"author":"Charles Martinez","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Charles Martinez","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#article","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/"},"author":{"name":"Charles Martinez","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560"},"headline":"L’activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d’initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche","datePublished":"2025-08-10T08:55:53+00:00","dateModified":"2025-08-10T08:55:53+00:00","mainEntityOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/"},"wordCount":493,"publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg","keywords":["CDC42","cl\u00e9","conduisant","dinitiation","\u00e9lev\u00e9e","est","\u00e9v\u00e9nement","lactivit\u00e9","prot\u00e9inurie","recherche","r\u00e9v\u00e8le"],"articleSection":["Les maladies"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/","url":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/","name":"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche - RVH-Synergie.org","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#website"},"primaryImageOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg","datePublished":"2025-08-10T08:55:53+00:00","dateModified":"2025-08-10T08:55:53+00:00","breadcrumb":{"@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#primaryimage","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/08\/1754816153_Lactivite-elevee-du-CDC42-est-un-evenement-dinitiation-cle-conduisant.jpg","width":1280,"height":720,"caption":"L'activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d'initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche"},{"@type":"BreadcrumbList","@id":"https:\/\/rvh-synergie.org\/actualites\/lactivite-elevee-du-cdc42-est-un-evenement-dinitiation-cle-conduisant-a-la-proteinurie-revele-la-recherche\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/rvh-synergie.org\/actualites\/"},{"@type":"ListItem","position":2,"name":"L’activit\u00e9 \u00e9lev\u00e9e du CDC42 est un \u00e9v\u00e9nement d’initiation cl\u00e9 conduisant \u00e0 la prot\u00e9inurie, r\u00e9v\u00e8le la recherche"}]},{"@type":"WebSite","@id":"https:\/\/rvh-synergie.org\/actualites\/#website","url":"https:\/\/rvh-synergie.org\/actualites\/","name":"RVH-Synergie.org","description":"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.","publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/rvh-synergie.org\/actualites\/#organization","name":"RVH-Synergie.org","url":"https:\/\/rvh-synergie.org\/actualites\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","width":512,"height":512,"caption":"RVH-Synergie.org"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560","name":"Charles Martinez","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","caption":"Charles Martinez"},"description":"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.","sameAs":["https:\/\/rvh-synergie.org\/"]}]}},"_links":{"self":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/8534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/comments?post=8534"}],"version-history":[{"count":0,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/8534\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media\/8535"}],"wp:attachment":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media?parent=8534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/categories?post=8534"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/tags?post=8534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}