{"id":7862,"date":"2025-07-10T02:55:50","date_gmt":"2025-07-10T00:55:50","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-revelent-comment-la-proteine-du-virus-du-virus-depstein-barr-ebna-lp-recable-ladn-pour-conduire-un-cancer\/"},"modified":"2025-07-10T02:55:51","modified_gmt":"2025-07-10T00:55:51","slug":"les-scientifiques-revelent-comment-la-proteine-du-virus-du-virus-depstein-barr-ebna-lp-recable-ladn-pour-conduire-un-cancer","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-revelent-comment-la-proteine-du-virus-du-virus-depstein-barr-ebna-lp-recable-ladn-pour-conduire-un-cancer\/","title":{"rendered":"Les scientifiques r\u00e9v\u00e8lent comment la prot\u00e9ine du virus du virus d’Epstein-Barr Ebna-LP rec\u00e2ble l’ADN pour conduire un cancer"},"content":{"rendered":"
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Les scientifiques de l’Institut Wistar ont d\u00e9couvert comment une prot\u00e9ine cl\u00e9 du virus Epstein-Barr (EBV), EBNA-LP, rec\u00e2ble fondamentalement la structure tridimensionnelle de l’ADN dans les cellules B infect\u00e9es pour favoriser le d\u00e9veloppement du cancer.<\/p>\n

La recherche, publi\u00e9e dans Recherche des acides nucl\u00e9iques<\/i>r\u00e9v\u00e8le que la prot\u00e9ine virale d\u00e9verrouille les coupes restreintes du g\u00e9nome de la cellule immunitaire, permettant des voies de croissance des cellules canc\u00e9reuses.<\/p>\n

\u00ab\u00a0C’est la premi\u00e8re fois que nous avons montr\u00e9 que EBNA-LP a la capacit\u00e9 de d\u00e9tourner la fonction des cellules h\u00f4tes, celles infect\u00e9es par l’EBV, pour activer les r\u00e9gions du g\u00e9nome qui ne devraient g\u00e9n\u00e9ralement pas \u00eatre activ\u00e9es\u00a0\u00bb, a d\u00e9clar\u00e9 Italo Tempera, Ph.D., professeur agr\u00e9g\u00e9 dans le Genome Regulation and Cell Signaling Program de Wistar’s Ellen et Ronald Cancer Center et l’auteur principal de l’\u00e9tude. \u00ab\u00a0Le r\u00e9sultat est que le virus reprogramme les cellules B, ce qui les fait para\u00eetre plus jeunes et plus en plastique – des traits critiques pour l’adaptation du cancer.\u00a0\u00bb<\/p>\n

L’EBV, qui infecte plus de 90% de la population mondiale, provoque g\u00e9n\u00e9ralement des sympt\u00f4mes l\u00e9gers ou pas. Cependant, chez certains individus, le virus entra\u00eene des maladies graves, notamment des cancers multiples et des conditions auto-immunes comme la scl\u00e9rose en plaques. Tempera et les r\u00e9sultats de son \u00e9quipe aident \u00e0 expliquer comment l’EBV accomplit cette transformation au niveau mol\u00e9culaire.<\/p>\n

La prot\u00e9ine EBNA-LP d’EBV \u00e9tait auparavant consid\u00e9r\u00e9e comme une prot\u00e9ine \u00ab\u00a0auxiliaire\u00a0\u00bb, sans son propre r\u00f4le distinct. Cependant, Tempera et son \u00e9quipe ont utilis\u00e9 une technique de cartographie appel\u00e9e HICHIP (Hi-C combin\u00e9e avec l’immunopr\u00e9cipitation de la chromatine) pour montrer que EBNA-LP a une fonction unique: il interagit avec YY1, une prot\u00e9ine dans les cellules B qui aide normalement \u00e0 organiser la structure \u00e0 trois dimensions de l’ADN, et que l’interaction affecte la fa\u00e7on dont le g\u00e9nome est pli\u00e9. En modifiant la disposition du g\u00e9nome, les prot\u00e9ines permettent de lire des sections d’ADN qui seraient g\u00e9n\u00e9ralement inaccessibles.<\/p>\n

\u00ab\u00a0Pensez au g\u00e9nome comme une biblioth\u00e8que avec diff\u00e9rentes sections\u00a0\u00bb, a expliqu\u00e9 Tempera. \u00ab\u00a0Certains livres sont librement accessibles, tandis que d’autres sont derri\u00e8re des portes verrouill\u00e9es. Ebna-lp craque essentiellement ces portes, ce qui rend les r\u00e9gions g\u00e9nomiques restreintes accessibles alors qu’elles ne devraient pas l’\u00eatre.\u00a0\u00bb<\/p>\n

Ce processus convertit les cellules B matures et diff\u00e9renci\u00e9es en un \u00e9tat plus na\u00eff de type cellule. L’\u00e9quipe de recherche a constat\u00e9 que cette reprogrammation augmente la plasticit\u00e9 des cellules, ce qui rend les cellules infect\u00e9es plus adaptables et r\u00e9actives aux signaux qui favorisent la croissance canc\u00e9reuse.<\/p>\n

EBNA-LP rejoint deux autres prot\u00e9ines virales, EBNA1 et EBNA2, en affectant la fa\u00e7on dont les g\u00e9nomes des cellules B sont pli\u00e9s. Le fait que le virus ait \u00e9volu\u00e9 plusieurs prot\u00e9ines pour cibler le m\u00eame processus cellulaire signale que ce m\u00e9canisme est essentiel pour le succ\u00e8s de l’infection – et r\u00e9v\u00e8le une vuln\u00e9rabilit\u00e9 qui pourrait \u00eatre exploit\u00e9e par les traitements contre le cancer li\u00e9s \u00e0 l’EBV, qui font actuellement d\u00e9faut.<\/p>\n

\u00ab\u00a0Il y a une grande lacune dans la fa\u00e7on dont nous traitons actuellement les maladies li\u00e9es \u00e0 l’EBV\u00a0\u00bb, a not\u00e9 Tempera. \u00ab\u00a0Nous traitons les sympt\u00f4mes du cancer ou les sympt\u00f4mes auto-immunes, mais nous n’avons pas encore de moyen de cibler sp\u00e9cifiquement le virus lui-m\u00eame. Cette recherche fournit une compr\u00e9hension m\u00e9caniste qui pourrait conduire \u00e0 des th\u00e9rapies sp\u00e9cifiques \u00e0 l’EBV.\u00a0\u00bb<\/p>\n

Les r\u00e9sultats de l’\u00e9tude sugg\u00e8rent \u00e9galement que des m\u00e9canismes de restructuration du g\u00e9nome similaires pourraient se produire dans les cancers non EBV par des mutations g\u00e9n\u00e9tiques. Cela cr\u00e9e la possibilit\u00e9 de nouvelles approches th\u00e9rapeutiques encore plus largement applicables.<\/p>\n

\u00ab\u00a0Les virus ne r\u00e9inventent pas les m\u00e9canismes cellulaires – ils saisissent les outils existants et les utilisent pour leurs propres fins.<\/p>\n

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Les scientifiques de l’Institut Wistar ont d\u00e9couvert comment une prot\u00e9ine cl\u00e9 du virus Epstein-Barr (EBV),<\/p>\n","protected":false},"author":1,"featured_media":7863,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[391,182,388,5963,5964,1172,49,8,1033,5965,149,97,630],"class_list":["post-7862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-cancer","tag-comment","tag-conduire","tag-depsteinbarr","tag-ebnalp","tag-ladn","tag-les","tag-pour","tag-proteine","tag-recable","tag-revelent","tag-scientifiques","tag-virus","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLes scientifiques r\u00e9v\u00e8lent comment la prot\u00e9ine du virus du virus d'Epstein-Barr Ebna-LP rec\u00e2ble l'ADN pour conduire un cancer - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/les-scientifiques-revelent-comment-la-proteine-du-virus-du-virus-depstein-barr-ebna-lp-recable-ladn-pour-conduire-un-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les scientifiques r\u00e9v\u00e8lent comment la prot\u00e9ine du virus du virus d'Epstein-Barr Ebna-LP rec\u00e2ble l'ADN pour conduire un cancer - 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