{"id":7422,"date":"2025-06-21T18:56:00","date_gmt":"2025-06-21T16:56:00","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/reseau-de-communication-cellulaire-qui-accelere-la-fibrose-hepatique-decouverte\/"},"modified":"2025-06-21T18:56:02","modified_gmt":"2025-06-21T16:56:02","slug":"reseau-de-communication-cellulaire-qui-accelere-la-fibrose-hepatique-decouverte","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/reseau-de-communication-cellulaire-qui-accelere-la-fibrose-hepatique-decouverte\/","title":{"rendered":"R\u00e9seau de communication cellulaire qui acc\u00e9l\u00e8re la fibrose h\u00e9patique d\u00e9couverte"},"content":{"rendered":"
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La fibrose du foie, une condition pathologique dans laquelle le foie devient raide et marqu\u00e9, se d\u00e9veloppe couramment dans la progression des maladies h\u00e9patiques chroniques telles que l’h\u00e9patite chronique et la st\u00e9atoh\u00e9patite associ\u00e9e au dysfonctionnement m\u00e9tabolique (MASH). Parce que la fibrose avanc\u00e9e peut conduire \u00e0 une cirrhose ou un cancer du foie, la compr\u00e9hension des m\u00e9canismes sous-jacentes est essentiel pour d\u00e9velopper des th\u00e9rapies efficaces.<\/p>\n

Une \u00e9quipe de recherche dirig\u00e9e par le Dr Takao Seki (professeur adjoint) et le Dr Hiroyasu Nakano (professeur sp\u00e9cialement nomm\u00e9) \u00e0 la Facult\u00e9 de m\u00e9decine de l’Universit\u00e9 Toho, a d\u00e9couvert un r\u00e9seau intercellulaire inconnu qui promeut la fibrose h\u00e9patique. Leurs r\u00e9sultats, publi\u00e9s dans iscience<\/i>mettez en \u00e9vidence les r\u00f4les critiques des cellules stellaires h\u00e9patiques et de deux mol\u00e9cules cl\u00e9s: le facteur de croissance FGF18 et l’ost\u00e9opontine m\u00e9diatrice pro-fibrotique (OPN).<\/p>\n

Dans des conditions physiologiques normales, les cellules stellaires h\u00e9patiques restent au repos et servent \u00e0 stocker la vitamine A. Cependant, lors d’une l\u00e9sion h\u00e9patique, ils se transforment en myofibroblastes qui produisent activement du collag\u00e8ne et d’autres composants de matrice extracellulaire, contribuant \u00e0 la fibrose. Cette \u00e9tude r\u00e9v\u00e8le comment ces cellules brillantes s’influencent mutuellement pour propager l’activit\u00e9 fibrotique.<\/p>\n

Les chercheurs ont d’abord d\u00e9montr\u00e9 que la stimulation des cellules stellaires h\u00e9patiques activ\u00e9es avec FGF18 am\u00e9liore consid\u00e9rablement la production d’OPN. Ils ont en outre montr\u00e9 que l’OPN agit sur les cellules stellaires au repos voisines pour induire leur activation, \u00e9tablissant une boucle de r\u00e9troaction positive. Fait int\u00e9ressant, l’OPN n’agit pas sur les cellules d\u00e9j\u00e0 activ\u00e9es mais cible sp\u00e9cifiquement celles au repos, r\u00e9partissant efficacement la fibrose d’une mani\u00e8re pass\u00e9e d’une cellule \u00e0 l’autre.<\/p>\n

En utilisant un mod\u00e8le de souris de fibrose h\u00e9patique, l’\u00e9quipe a constat\u00e9 que l’OPN transmet les signaux via un r\u00e9cepteur de surface cellulaire appel\u00e9 int\u00e9grine, soulignant comment la \u00ab\u00a0communication\u00a0\u00bb mol\u00e9culaire entre les cellules stellates entra\u00eene le processus fibrotique.<\/p>\n

Ces r\u00e9sultats identifient un nouveau syst\u00e8me de communication intercellulaire auto-amplifiant dans la fibrose h\u00e9patique, m\u00e9di\u00e9 par FGF18 et OPN. Plut\u00f4t que d’\u00eatre une cons\u00e9quence d’une seule mol\u00e9cule, la fibrose est une r\u00e9ponse dynamique et coordonn\u00e9e impliquant la signalisation cellulaire-cellule et les signaux environnementaux. Cette d\u00e9couverte offre une nouvelle perspective sur la pathogen\u00e8se de la fibrose h\u00e9patique.<\/p>\n

L’axe FGF18 – OPN est \u00e9galement une cible th\u00e9rapeutique prometteuse. \u00c9tant donn\u00e9 que le FGF18 agit s\u00e9lectivement sur les cellules stellaires h\u00e9patiques, les th\u00e9rapies bas\u00e9es sur cette voie peuvent offrir des interventions sp\u00e9cifiques aux cellules qui \u00e9vitent les effets g\u00e9n\u00e9raux des m\u00e9dicaments cibl\u00e9s par le foie conventionnels.<\/p>\n

L’\u00e9tude a \u00e9t\u00e9 men\u00e9e en collaboration avec le Dr Yuichi Tsuchiya (professeur agr\u00e9g\u00e9, Facult\u00e9 des sciences pharmaceutiques, Universit\u00e9 Toho) et le Dr Minoru Tanaka (chef de division, National Center for Global Health and Medicine Research Institute).<\/p>\n

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La fibrose du foie, une condition pathologique dans laquelle le foie devient raide et marqu\u00e9,<\/p>\n","protected":false},"author":1,"featured_media":7423,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3310,386,1339,2305,654,655,193,5501],"class_list":["post-7422","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-accelere","tag-cellulaire","tag-communication","tag-decouverte","tag-fibrose","tag-hepatique","tag-qui","tag-reseau","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nR\u00e9seau de communication cellulaire qui acc\u00e9l\u00e8re la fibrose h\u00e9patique d\u00e9couverte - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/reseau-de-communication-cellulaire-qui-accelere-la-fibrose-hepatique-decouverte\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R\u00e9seau de communication cellulaire qui acc\u00e9l\u00e8re la fibrose h\u00e9patique d\u00e9couverte - 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