{"id":7401,"date":"2025-06-20T18:57:18","date_gmt":"2025-06-20T16:57:18","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/biomarqueurs-sanguins-du-cordon-ombilical-dune-septicemie-a-debut-precoce-identifie-chez-les-nouveau-nes-prematures\/"},"modified":"2025-06-20T18:57:19","modified_gmt":"2025-06-20T16:57:19","slug":"biomarqueurs-sanguins-du-cordon-ombilical-dune-septicemie-a-debut-precoce-identifie-chez-les-nouveau-nes-prematures","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/biomarqueurs-sanguins-du-cordon-ombilical-dune-septicemie-a-debut-precoce-identifie-chez-les-nouveau-nes-prematures\/","title":{"rendered":"Biomarqueurs sanguins du cordon ombilical d’une septic\u00e9mie \u00e0 d\u00e9but pr\u00e9coce identifi\u00e9 chez les nouveau-n\u00e9s pr\u00e9matur\u00e9s"},"content":{"rendered":"
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Des scientifiques de Stanley Manne Children’s Research Institute de l’Ann & Robert H. Lurie Children’s Hospital de Chicago et des coll\u00e8gues ont identifi\u00e9 plusieurs prot\u00e9ines du sang du cordon ombilical des nouveau-n\u00e9s pr\u00e9matur\u00e9s qui signalent une inflammation syst\u00e9mique aigu\u00eb comme une r\u00e9ponse immunitaire \u00e0 une infection, fournissant des moyens objectifs et non invasifs pour diagnostiquer les septic\u00e9es.<\/p>\n

Cette constatation pourrait \u00e9pargner les nourrissons d’une exposition prolong\u00e9e \u00e0 des antibiotiques inutiles, ce qui les laisse \u00e0 risque d’infections graves et de d\u00e9r\u00e9gulation ult\u00e9rieures du microbiome qui peuvent avoir un impact sur le syst\u00e8me immunitaire et le m\u00e9tabolisme. Les r\u00e9sultats ont \u00e9t\u00e9 publi\u00e9s dans JCI Insight<\/i>.<\/p>\n

La septic\u00e9mie d\u00e9butant se produit dans les 72 heures de vie et est plus fr\u00e9quente chez les nourrissons pr\u00e9matur\u00e9s. Il se d\u00e9veloppe g\u00e9n\u00e9ralement en utero et l’infection intra-amniotique est souvent le d\u00e9clencheur de la naissance pr\u00e9matur\u00e9e. La septic\u00e9mie \u00e0 d\u00e9but pr\u00e9coce est difficile \u00e0 diagnostiquer d\u00e9finitivement \u00e0 partir des signes cliniques, de sorte que les antibiotiques sont lanc\u00e9s en attendant les r\u00e9sultats de la culture.<\/p>\n

Parmi les nourrissons tr\u00e8s faibles \u00e0 la naissance \u00e0 l’\u00e9chelle nationale, 78% re\u00e7oivent des antibiotiques apr\u00e8s l’accouchement. Environ 25% de ces b\u00e9b\u00e9s se poursuivent sur des antibiotiques m\u00eame lorsque les r\u00e9sultats de la culture sont n\u00e9gatifs car ils sont pr\u00e9sum\u00e9s avoir une septic\u00e9mie.<\/p>\n

\u00ab\u00a0Le sang du cordon est une excellente source d’informations sur l’\u00e9tat de la sant\u00e9 du b\u00e9b\u00e9 au moment de l’accouchement. Les r\u00e9sultats des biomarqueurs sanguins du cordon peuvent \u00eatre disponibles dans les 24 heures, permettant aux m\u00e9decins d’exclure la septic\u00e9mie d\u00e9butant et d’arr\u00eater les antibiotiques avec plus de confiance\u00a0\u00bb, a d\u00e9clar\u00e9 l’autoroute principale Leena B. Mithal, MD, p\u00e9diatre infectieuse des maladies de la recherche, des enfants, des enfants de Kathleen, et de Kathleen, et de la gueule en tant que professeur agr\u00e9g\u00e9 de p\u00e9diatrie \u00e0 la Northwestern University Feinberg School of Medicine.<\/p>\n

\u00ab\u00a0Cela pourrait \u00eatre une avanc\u00e9e importante dans la garde des nourrissons pr\u00e9matur\u00e9s.\u00a0\u00bb<\/p>\n

Le Dr Mithal et ses coll\u00e8gues ont \u00e9galement d\u00e9velopp\u00e9 un algorithme de diagnostic d’apprentissage automatique bas\u00e9 sur les biomarqueurs du sang du cordon et les facteurs de risque de septic\u00e9mie \u00e0 d\u00e9but pr\u00e9coce. Cette innovation a un brevet en instance.<\/p>\n

\u00ab\u00a0La prochaine \u00e9tape sera de valider nos r\u00e9sultats gr\u00e2ce \u00e0 des \u00e9tudes multicentriques et \u00e0 des essais cliniques\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Mithal.<\/p>\n

Patrick Seed, MD, Ph.D., pr\u00e9sident et directeur de recherche au Manne Research Institute, a \u00e9t\u00e9 co-auteur de l’\u00e9tude. Il est pr\u00e9sident du Fonds de recherche pour enfants en sciences fondamentales et professeur de p\u00e9diatrie et de microbiologie – immunologie \u00e0 la Northwestern University Feinberg School of Medicine.<\/p>\n

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Des scientifiques de Stanley Manne Children’s Research Institute de l’Ann & Robert H. 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