{"id":7150,"date":"2025-06-09T23:56:15","date_gmt":"2025-06-09T21:56:15","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/"},"modified":"2025-06-09T23:56:17","modified_gmt":"2025-06-09T21:56:17","slug":"une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/","title":{"rendered":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne"},"content":{"rendered":"
\n
\n
\n
\n<\/figure><\/div>\n<\/div>\n

La coca\u00efne, une drogue d’abus, active juste une partie – 10% \u00e0 20% – des neurones du noyau du cerveau accumbens, une r\u00e9gion critique li\u00e9e \u00e0 la motivation et \u00e0 la d\u00e9pendance. Bien que petit en nombre, cette population neuronale activ\u00e9e contr\u00f4le fortement le comportement li\u00e9 au m\u00e9dicament par des changements en aval dans l’expression des g\u00e8nes, les synapses nerveuses, les circuits neuronaux et la fonction neuronale qui conduisent \u00e0 un changement de comportement, y compris la d\u00e9pendance.<\/p>\n

Dans une \u00e9tude publi\u00e9e dans Avanc\u00e9es scientifiques<\/i>University of Alabama at Birmingham Researchers dirig\u00e9 par Kasey Brida et Jeremy Day, Ph.D., rapportent que la glycoprot\u00e9ine s\u00e9cr\u00e9t\u00e9e Reelin est un marqueur de ces neurones du noyau accumbens qui ont \u00e9t\u00e9 activ\u00e9s par la coca\u00efne.<\/p>\n

Afin de d\u00e9terminer si Reelin contribue aux changements cellulaires et comportementaux li\u00e9s au m\u00e9dicament, l’\u00e9quipe a d\u00e9velopp\u00e9 une strat\u00e9gie d’interf\u00e9rence CRISPR pour cibler et r\u00e9duire l’expression du g\u00e8ne de Reelin dans les neurones Nucleus Accumbens.<\/p>\n

La suppression de Reelin chez le rat a diminu\u00e9 l’expression des g\u00e8nes associ\u00e9e \u00e0 l’activation par la coca\u00efne, une alt\u00e9ration de l’expression des canaux ioniques li\u00e9s \u00e0 l’excitabilit\u00e9 neuronale et \u00e0 l’excitabilit\u00e9 alt\u00e9r\u00e9e des neurones du noyau accumbens. Le knockdown a \u00e9galement aboli les changements comportementaux induits par la coca\u00efne dans le mouvement et la pr\u00e9f\u00e9rence de place, et il a att\u00e9nu\u00e9 l’auto-administration de la coca\u00efne par les rats.<\/p>\n

\u00ab\u00a0Ensemble, ces r\u00e9sultats identifient Reelin comme un marqueur stable des neurones sensibles \u00e0 la coca\u00efne et r\u00e9v\u00e8lent un r\u00f4le cl\u00e9 pour Reelin dans les propri\u00e9t\u00e9s transcriptionnelles, \u00e9lectrophysiologiques et comportementales de la plasticit\u00e9 striatale induite par la coca\u00efne\u00a0\u00bb, a d\u00e9clar\u00e9 Brida, \u00e9tudiant dipl\u00f4m\u00e9 du Day’s UAB Department of Neurobiology Lab.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats mettent en \u00e9vidence une opportunit\u00e9 de manipulation de haute pr\u00e9cision des circuits de r\u00e9compense \u00e0 l’aide d’outils bas\u00e9s sur Reelin, r\u00e9v\u00e8lent la n\u00e9cessit\u00e9 de Reelin dans la r\u00e9ponse cellulaire \u00e0 la coca\u00efne et impliquent la voie de signalisation de Reelin comme cible th\u00e9rapeutique potentielle pour le trouble de l’utilisation de la coca\u00efne.\u00a0\u00bb<\/p>\n

Des \u00e9tudes ant\u00e9rieures ont d\u00e9montr\u00e9 que les effets de la coca\u00efne sur le noyau accumbens se produisent dans des neurones \u00e9pineux moyens, qui sont le type neuronal principal dans cette r\u00e9gion du cerveau et expriment des r\u00e9cepteurs pour la dopamine des neurotransmetteurs. Les chercheurs ont identifi\u00e9 Reelin comme un marqueur des neurones \u00e9pineux moyens activ\u00e9s par la coca\u00efne en tirant parti des ensembles de donn\u00e9es de s\u00e9quen\u00e7age d’ARN unique non biais\u00e9 apr\u00e8s l’exposition \u00e0 la coca\u00efne.<\/p>\n

Plus de 80% des neurones \u00e9pineux moyens activ\u00e9s dans le noyau accumbens ont exprim\u00e9 l’ARNm de Reelin, avec une expression moyenne environ 10 fois sup\u00e9rieure \u00e0 celle des neurones qui n’\u00e9taient pas activ\u00e9es par la coca\u00efne. Ils ont \u00e9galement montr\u00e9 que Reelin est enrichi dans une sous-population de neurones \u00e9pineux moyens chez le rat et le cerveau humain.<\/p>\n

Les chercheurs ont ensuite utilis\u00e9 le knockdown d’interf\u00e9rence CRISPR de l’expression de Reelin pour identifier ses influences sur la physiologie des neurones \u00e9pineux moyens et les comportements li\u00e9s au m\u00e9dicament. Le syst\u00e8me d’interf\u00e9rence CRISPR a \u00e9t\u00e9 transport\u00e9 par les lentivirus inject\u00e9s directement dans le noyau accumbens du cerveau de rat. Les exp\u00e9riences de knockdown sugg\u00e8rent ensemble que l’expression de Reelin permet aux neurones d’\u00eatre excitables et de d\u00e9clencher des cascades de transduction du signal que la coca\u00efne utilise pour fa\u00e7onner la fonction neuronale sur des \u00e9chelles de temps plus longues, dit Brida.<\/p>\n

Reelin est connu depuis longtemps pour \u00eatre crucial pour le d\u00e9veloppement du cerveau des mammif\u00e8res pendant l’embryogen\u00e8se, et il est \u00e9galement connu pour jouer un r\u00f4le dans la plasticit\u00e9 et la fonction synaptiques dans le cerveau adulte. Reelin a \u00e9galement des liens vers divers troubles neuropsychiatriques. Pourtant, la constatation que l’ARNm pour la prot\u00e9ine Reelin a \u00e9t\u00e9 enrichi en neurones \u00e9pineux moyens qui ont \u00e9t\u00e9 activ\u00e9s par la coca\u00efne \u00e9taient inattendus, disent Brida et Day.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

La coca\u00efne, une drogue d’abus, active juste une partie – 10% \u00e0 20% – des<\/p>\n","protected":false},"author":1,"featured_media":7151,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[4704,2710,1010,4783,49,5620,2168,540,1895,3915,47],"class_list":["post-7150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-actives","tag-cerebraux","tag-cocaine","tag-glycoproteine","tag-les","tag-marque","tag-neurones","tag-par","tag-recompense","tag-regule","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"La coca\u00efne, une drogue d’abus, active juste une partie – 10% \u00e0 20% – des\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\" \/>\n<meta property=\"og:site_name\" content=\"RVH-Synergie\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-09T21:56:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-09T21:56:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"829\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Charles Martinez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Charles Martinez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\"},\"author\":{\"name\":\"Charles Martinez\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\"},\"headline\":\"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne\",\"datePublished\":\"2025-06-09T21:56:15+00:00\",\"dateModified\":\"2025-06-09T21:56:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\"},\"wordCount\":755,\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg\",\"keywords\":[\"actives\",\"c\u00e9r\u00e9braux\",\"Coca\u00efne\",\"glycoprot\u00e9ine\",\"Les\",\"marque\",\"neurones\",\"par\",\"r\u00e9compense\",\"r\u00e9gule\",\"une\"],\"articleSection\":[\"Les addictions\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\",\"name\":\"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne - RVH-Synergie.org\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg\",\"datePublished\":\"2025-06-09T21:56:15+00:00\",\"dateModified\":\"2025-06-09T21:56:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg\",\"width\":1280,\"height\":829,\"caption\":\"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/rvh-synergie.org\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"name\":\"RVH-Synergie.org\",\"description\":\"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.\",\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\",\"name\":\"RVH-Synergie.org\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"width\":512,\"height\":512,\"caption\":\"RVH-Synergie.org\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\",\"name\":\"Charles Martinez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"caption\":\"Charles Martinez\"},\"description\":\"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.\",\"sameAs\":[\"https:\/\/rvh-synergie.org\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne - RVH-Synergie.org","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/","og_locale":"fr_FR","og_type":"article","og_title":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne - RVH-Synergie.org","og_description":"La coca\u00efne, une drogue d’abus, active juste une partie – 10% \u00e0 20% – des","og_url":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/","og_site_name":"RVH-Synergie","article_published_time":"2025-06-09T21:56:15+00:00","article_modified_time":"2025-06-09T21:56:17+00:00","og_image":[{"width":1280,"height":829,"url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg","type":"image\/jpeg"}],"author":"Charles Martinez","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Charles Martinez","Dur\u00e9e de lecture estim\u00e9e":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#article","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/"},"author":{"name":"Charles Martinez","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560"},"headline":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne","datePublished":"2025-06-09T21:56:15+00:00","dateModified":"2025-06-09T21:56:17+00:00","mainEntityOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/"},"wordCount":755,"publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg","keywords":["actives","c\u00e9r\u00e9braux","Coca\u00efne","glycoprot\u00e9ine","Les","marque","neurones","par","r\u00e9compense","r\u00e9gule","une"],"articleSection":["Les addictions"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/","url":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/","name":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne - RVH-Synergie.org","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#website"},"primaryImageOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg","datePublished":"2025-06-09T21:56:15+00:00","dateModified":"2025-06-09T21:56:17+00:00","breadcrumb":{"@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#primaryimage","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/06\/1749506176_Une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine.jpg","width":1280,"height":829,"caption":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne"},{"@type":"BreadcrumbList","@id":"https:\/\/rvh-synergie.org\/actualites\/une-glycoproteine-marque-les-neurones-cerebraux-actives-par-la-cocaine-et-regule-la-recompense-de-cocaine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/rvh-synergie.org\/actualites\/"},{"@type":"ListItem","position":2,"name":"Une glycoprot\u00e9ine marque les neurones c\u00e9r\u00e9braux activ\u00e9s par la coca\u00efne et r\u00e9gule la r\u00e9compense de coca\u00efne"}]},{"@type":"WebSite","@id":"https:\/\/rvh-synergie.org\/actualites\/#website","url":"https:\/\/rvh-synergie.org\/actualites\/","name":"RVH-Synergie.org","description":"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.","publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/rvh-synergie.org\/actualites\/#organization","name":"RVH-Synergie.org","url":"https:\/\/rvh-synergie.org\/actualites\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","width":512,"height":512,"caption":"RVH-Synergie.org"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560","name":"Charles Martinez","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","caption":"Charles Martinez"},"description":"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.","sameAs":["https:\/\/rvh-synergie.org\/"]}]}},"_links":{"self":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/7150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/comments?post=7150"}],"version-history":[{"count":0,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/7150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media\/7151"}],"wp:attachment":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media?parent=7150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/categories?post=7150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/tags?post=7150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}