{"id":6597,"date":"2025-05-18T06:56:38","date_gmt":"2025-05-18T04:56:38","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/syndrome-de-marfan-lie-a-une-inflammation-accrue-du-cerveau-et-a-un-risque-neurologique\/"},"modified":"2025-05-18T06:56:39","modified_gmt":"2025-05-18T04:56:39","slug":"syndrome-de-marfan-lie-a-une-inflammation-accrue-du-cerveau-et-a-un-risque-neurologique","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/syndrome-de-marfan-lie-a-une-inflammation-accrue-du-cerveau-et-a-un-risque-neurologique\/","title":{"rendered":"Syndrome de Marfan li\u00e9 \u00e0 une inflammation accrue du cerveau et \u00e0 un risque neurologique"},"content":{"rendered":"
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Une \u00e9tude de l’Institut de Neuroci\u00e8nes de l’Universitat Aut\u00f2noma de Barcelone (Inc-Uab) r\u00e9v\u00e8le que l’inflammation associ\u00e9e au syndrome de Marfan augmente la vuln\u00e9rabilit\u00e9 aux maladies neurologiques et aux complications apr\u00e8s des accidents vasculaires c\u00e9r\u00e9braux, comme d\u00e9montr\u00e9 dans les mod\u00e8les animaux.<\/p>\n

Publi\u00e9 dans Biologie redox<\/i>la recherche souligne que le syndrome de Marfan, un trouble g\u00e9n\u00e9tique affectant environ 1 sur 5 000 personnes et principalement connu pour ses complications cardiovasculaires, a \u00e9galement un impact sur la sant\u00e9 du cerveau. Les r\u00e9sultats montrent que la condition augmente la sensibilit\u00e9 du cerveau aux dommages caus\u00e9s par une r\u00e9duction de l’approvisionnement en oxyg\u00e8ne (comme dans les crises cardiaques ou les h\u00e9morragies graves) et augmente le risque de troubles neurologiques ult\u00e9rieurs.<\/p>\n

Ces r\u00e9sultats soulignent l’importance de reconna\u00eetre et de g\u00e9rer les risques neurologiques chez les patients marfan pour pr\u00e9venir les complications et am\u00e9liorer les r\u00e9sultats du traitement.<\/p>\n

Le syndrome de Marfan affecte le tissu conjonctif du corps, qui fournit un soutien structurel aux organes et aux tissus. Les personnes atteintes de la maladie \u00e9prouvent souvent des probl\u00e8mes dans le c\u0153ur, les yeux, les vaisseaux sanguins et le squelette. Si l’aorte s’affaiblit ou se dilate, la condition peut devenir mortelle.<\/p>\n

En utilisant un mod\u00e8le de souris de la maladie, une \u00e9quipe de recherche dirig\u00e9e par le professeur Francesc Jim\u00e9nez-Altay\u00f3 – Resetteur au D\u00e9partement de pharmacologie, de la th\u00e9rapeutique et de la toxicologie, de l’inc-Uab et du domaine des maladies cardiovasculaires du centre de r\u00e9seaux de recherche biom\u00e9dicale (CiberCV) – a montr\u00e9 que le syndrome de la marfane augmente \u00e9galement le risque des l\u00e9sions c\u00e9r\u00e9ali\u00e8res. L’\u00e9tude a \u00e9galement explor\u00e9 comment le sexe et l’\u00e2ge affectent cette vuln\u00e9rabilit\u00e9.<\/p>\n

L’\u00e9quipe a compar\u00e9 des souris masculines et f\u00e9minines, jeunes et vieillies, avec et sans syndrome de Marfan. Ils ont analys\u00e9 l’activit\u00e9 des g\u00e8nes en utilisant le s\u00e9quen\u00e7age d’ARN et \u00e9valu\u00e9 les biomarqueurs de l’inflammation et de la sant\u00e9 des tissus. De plus, ils ont \u00e9tudi\u00e9 la structure et la fonction des vaisseaux sanguins c\u00e9r\u00e9braux et ont \u00e9valu\u00e9 la r\u00e9ponse du cerveau \u00e0 l’interruption temporaire du flux sanguin.<\/p>\n

Les r\u00e9sultats ont r\u00e9v\u00e9l\u00e9 des changements marqu\u00e9s dans l’expression des g\u00e8nes, en particulier chez les jeunes hommes et les femmes \u00e2g\u00e9es, impliquant en particulier les prot\u00e9ines li\u00e9es \u00e0 l’inflammation et \u00e0 la r\u00e9paration des tissus. Quel que soit l’\u00e2ge ou le sexe, les souris marfanes ont montr\u00e9 une inflammation c\u00e9r\u00e9brale g\u00e9n\u00e9ralis\u00e9e des premiers stades de la vie, indiquant un d\u00e9s\u00e9quilibre persistant dans l’hom\u00e9ostasie du cerveau.<\/p>\n

L’\u00e9tude a r\u00e9v\u00e9l\u00e9 des perturbations dans la signalisation d’une prot\u00e9ine r\u00e9gulatrice cl\u00e9 – TGF-\u03b2 (transformateur du facteur de croissance b\u00eata) – ainsi que des alt\u00e9rations du renouvellement de la matrice extracellulaire et de l’int\u00e9grit\u00e9 des vaisseaux sanguins. Ces changements ont \u00e9t\u00e9 influenc\u00e9s par le sexe et l’\u00e2ge.<\/p>\n

\u00ab\u00a0Ces m\u00e9canismes peuvent aider \u00e0 expliquer pourquoi les individus atteints du syndrome de Marfan sont confront\u00e9s \u00e0 un risque plus \u00e9lev\u00e9 de d\u00e9velopper des probl\u00e8mes neurologiques, m\u00eame en l’absence d’\u00e9v\u00e9nements cardiovasculaires manifestes\u00a0\u00bb, explique Gemma Manich, auteur principal de l’article.<\/p>\n

\u00ab\u00a0Les r\u00e9sultats soulignent la n\u00e9cessit\u00e9 d’une sensibilisation accrue aux risques neurologiques potentiels chez les personnes vivant avec le syndrome de Marfan. En m\u00eame temps, ils indiquent des cibles possibles pour des approches de traitement personnalis\u00e9es en fonction de l’\u00e2ge et du sexe\u00a0\u00bb, conclut Francesc Jim\u00e9nez-Altay\u00f3.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9tude de l’Institut de Neuroci\u00e8nes de l’Universitat Aut\u00f2noma de Barcelone (Inc-Uab) r\u00e9v\u00e8le que l’inflammation<\/p>\n","protected":false},"author":1,"featured_media":6598,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[821,585,1708,954,5345,1775,40,283,47],"class_list":["post-6597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-accrue","tag-cerveau","tag-inflammation","tag-lie","tag-marfan","tag-neurologique","tag-risque","tag-syndrome","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nSyndrome de Marfan li\u00e9 \u00e0 une inflammation accrue du cerveau et \u00e0 un risque neurologique - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/syndrome-de-marfan-lie-a-une-inflammation-accrue-du-cerveau-et-a-un-risque-neurologique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Syndrome de Marfan li\u00e9 \u00e0 une inflammation accrue du cerveau et \u00e0 un risque neurologique - 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