{"id":6311,"date":"2025-05-07T03:56:16","date_gmt":"2025-05-07T01:56:16","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/pres-de-quart-des-personnes-sur-des-opioides-a-action-prolongee-developpent-une-dependance-revele-letude\/"},"modified":"2025-05-07T03:56:16","modified_gmt":"2025-05-07T01:56:16","slug":"pres-de-quart-des-personnes-sur-des-opioides-a-action-prolongee-developpent-une-dependance-revele-letude","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/pres-de-quart-des-personnes-sur-des-opioides-a-action-prolongee-developpent-une-dependance-revele-letude\/","title":{"rendered":"Pr\u00e8s de quart des personnes sur des opio\u00efdes \u00e0 action prolong\u00e9e d\u00e9veloppent une d\u00e9pendance, r\u00e9v\u00e8le l’\u00e9tude"},"content":{"rendered":"
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Selon une \u00e9tude nouvellement publi\u00e9e, plus d’une personne sur cinq a prescrit des analg\u00e9siques \u00e0 lib\u00e9ration prolong\u00e9e tels que l’oxycontin ont d\u00e9velopp\u00e9 une d\u00e9pendance en un an.<\/p>\n

L’\u00e9tude, retard\u00e9e \u00e0 plusieurs reprises de plus d’une d\u00e9cennie et lib\u00e9r\u00e9e le 5 mai, a r\u00e9v\u00e9l\u00e9 un pourcentage beaucoup plus \u00e9lev\u00e9 de patients atteints de douleur accro aux opio\u00efdes que les repr\u00e9sentants des ventes des fabricants de m\u00e9dicaments revendiqu\u00e9s dans leurs documents de marketing et leurs repr\u00e9sentations aux m\u00e9decins.<\/p>\n

La FDA fait maintenant face \u00e0 la question de savoir comment utiliser ces donn\u00e9es pour \u00e9valuer si l’agence devrait apporter des modifications \u00e0 la r\u00e9glementation des opio\u00efdes, limitant les larges approbations des opio\u00efdes \u00e0 action prolong\u00e9e pour une utilisation prolong\u00e9e. La FDA tient actuellement des audiences pour discuter des r\u00e9sultats et est invit\u00e9 par les d\u00e9fenseurs de modifier les \u00e9tiquettes des m\u00e9dicaments, qui guident comment les m\u00e9decins les prescrivent.<\/p>\n

Lorsque le march\u00e9 des opio\u00efdes a \u00e9t\u00e9 ouvert \u00e0 des millions de patients souffrant de douleur chronique dans les ann\u00e9es 1990 et au d\u00e9but des ann\u00e9es 2000, les repr\u00e9sentants commerciaux de Purdue Pharma et les vid\u00e9os promotionnelles ont affirm\u00e9 que moins de 1% des patients sont devenus d\u00e9pendants des analg\u00e9siques. Les pilules \u00e0 lib\u00e9ration prolong\u00e9e ont \u00e9t\u00e9 con\u00e7ues pour dose continuellement des opio\u00efdes pour \u00e9viter la douleur chronique.<\/p>\n

Les donn\u00e9es publi\u00e9es montrent que 22,5% des patients atteints de douleur qui ont commenc\u00e9 sur des m\u00e9dicaments \u00e0 lib\u00e9ration prolong\u00e9e et \u00e0 action prolong\u00e9e ont d\u00e9velopp\u00e9 un trouble d’utilisation des opio\u00efdes ou une d\u00e9pendance, dans un d\u00e9lai d’un an. Les r\u00e9sultats d\u00e9coulent d’une exigence d’\u00e9tude post-commercialisation mandat\u00e9e par la FDA en 2013.<\/p>\n

\u00ab\u00a0Les r\u00e9sultats sont frappants et d\u00e9rangeants et ils soul\u00e8vent des questions \u00e9thiques parce que tant de sujets d’\u00e9tude ont \u00e9t\u00e9 bless\u00e9s\u00a0\u00bb, a d\u00e9clar\u00e9 Andrew Kolodny, pr\u00e9sident de la prescription responsable des opio\u00efdes. \u00ab\u00a0Comment pouvez-vous avoir une \u00e9tiquette qui sugg\u00e8re que cela est s\u00fbr et efficace lorsque vous avez maintenant des preuves qu’il est dangereux et n’a toujours pas de preuve qu’il est efficace?\u00a0\u00bb<\/p>\n

En mars, Purdue a d\u00e9pos\u00e9 un plan de faillite de 7,4 milliards de dollars pour r\u00e9soudre des milliers de poursuites li\u00e9es au r\u00f4le de la soci\u00e9t\u00e9 dans l’\u00e9pid\u00e9mie d’opio\u00efdes. Un repr\u00e9sentant de Purdue a refus\u00e9 de commenter. Les porte-parole de Mallinckrodt et Endo n’\u00e9taient pas imm\u00e9diatement disponibles.<\/p>\n

Les efforts pour obtenir une image claire de la fa\u00e7on dont ces opio\u00efdes \u00e0 action prolong\u00e9e ont \u00e9t\u00e9 comprim\u00e9s au fil des ans alors que les fabricants de m\u00e9dicaments et les d\u00e9fenseurs des patients ont fait pression pour un acc\u00e8s facile aux opio\u00efdes et contest\u00e9 la d\u00e9finition de la \u00abd\u00e9pendance\u00bb. L’\u00e9pid\u00e9mie a co\u00fbt\u00e9 la vie \u00e0 plus de 800 000 personnes aux \u00c9tats-Unis depuis 1999 et reste un probl\u00e8me de sant\u00e9 publique majeur.<\/p>\n

Des millions d’Am\u00e9ricains sont devenus d\u00e9pendants des pilules opio\u00efdes, m\u00eame si des preuves croissantes sugg\u00e8rent que ces m\u00e9dicaments n’auraient jamais d\u00fb \u00eatre approuv\u00e9s comme s\u00fbrs et efficaces pour la douleur chronique.<\/p>\n

Le propre \u00e9tiquetage de l’agence – signifie d\u00e9finir l’utilisation d’un m\u00e9dicament, signaler ses risques et limiter sa commercialisation – a cess\u00e9 de l\u00e9gitimer une prescription g\u00e9n\u00e9ralis\u00e9e, \u00e0 haute dose \u00e0 long terme sans les preuves cliniques pour la soutenir, comme l’a r\u00e9v\u00e9l\u00e9 une enqu\u00eate sur les semaines d’affaires.<\/p>\n

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Selon une \u00e9tude nouvellement publi\u00e9e, plus d’une personne sur cinq a prescrit des analg\u00e9siques \u00e0<\/p>\n","protected":false},"author":1,"featured_media":431,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[1867,410,16,620,1346,411,100,527,2770,5197,157,112,47],"class_list":["post-6311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-action","tag-dependance","tag-des","tag-developpent","tag-letude","tag-opioides","tag-personnes","tag-pres","tag-prolongee","tag-quart","tag-revele","tag-sur","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nPr\u00e8s de quart des personnes sur des opio\u00efdes \u00e0 action prolong\u00e9e d\u00e9veloppent une d\u00e9pendance, r\u00e9v\u00e8le l'\u00e9tude - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/pres-de-quart-des-personnes-sur-des-opioides-a-action-prolongee-developpent-une-dependance-revele-letude\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pr\u00e8s de quart des personnes sur des opio\u00efdes \u00e0 action prolong\u00e9e d\u00e9veloppent une d\u00e9pendance, r\u00e9v\u00e8le l'\u00e9tude - 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