{"id":6134,"date":"2025-04-29T14:55:53","date_gmt":"2025-04-29T12:55:53","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/la-proteine-humaine-hsf2-aide-a-reveiller-les-virus-lies-au-cancer-decouvertes-a-letude\/"},"modified":"2025-04-29T14:55:55","modified_gmt":"2025-04-29T12:55:55","slug":"la-proteine-humaine-hsf2-aide-a-reveiller-les-virus-lies-au-cancer-decouvertes-a-letude","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/la-proteine-humaine-hsf2-aide-a-reveiller-les-virus-lies-au-cancer-decouvertes-a-letude\/","title":{"rendered":"La prot\u00e9ine humaine HSF2 aide \u00e0 r\u00e9veiller les virus li\u00e9s au cancer, d\u00e9couvertes \u00e0 l’\u00e9tude"},"content":{"rendered":"
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Une nouvelle \u00e9quipe de chercheurs de l’Universit\u00e9 \u00c5bo Akademi, dirig\u00e9e par la recherche de l’Acad\u00e9mie Silvia Gramolelli (Facult\u00e9 de sciences et d’ing\u00e9nierie), a d\u00e9couvert une fonction suppl\u00e9mentaire pour le facteur de choc thermique 2 (HSF2), un facteur de transcription humaine non associ\u00e9 auparavant \u00e0 des processus viraux.<\/p>\n

L’\u00e9tude, publi\u00e9e dans Pathog\u00e8nes PLOS<\/i>d\u00e9montre la capacit\u00e9 de HSF2 \u00e0 remodeler l’ADN viral \u00e0 permettre la transition de la latence virale dormante \u00e0 la r\u00e9activation lytique active. Les deux gamma-herp\u00e8svirus humains, en particulier l’herp\u00e8svirus du sarcome de Kaposi (KSHV) et le virus d’Epstein – Barr (EBV), provoquent plusieurs types de cancer.<\/p>\n

Ces virus \u00e9tablissent une persistance \u00e0 vie chez l’homme et restent g\u00e9n\u00e9ralement inactifs ou latentes, mais dans certaines conditions, ils peuvent r\u00e9activer et produire de nouveaux virus. Ce processus de r\u00e9activation joue un r\u00f4le cl\u00e9 dans la propagation virale et contribue remarquablement au d\u00e9veloppement du cancer. Cependant, de nombreux facteurs humains soutenant ce passage de la dormance virale \u00e0 l’activit\u00e9 restent inconnus.<\/p>\n

L’\u00e9quipe a d\u00e9couvert que HSF2, un facteur de transcription impliqu\u00e9 dans la r\u00e9ponse et le d\u00e9veloppement du stress, est un acteur cl\u00e9 de ce processus de r\u00e9activation. Notamment, HSF2 n’a jamais \u00e9t\u00e9 li\u00e9 auparavant \u00e0 aucun cycle de vie viral.<\/p>\n

En augmentant les niveaux de HSF2 dans les cellules infect\u00e9es par le virus, les chercheurs ont observ\u00e9 une augmentation de l’activit\u00e9 des g\u00e8nes viraux. Inversement, la r\u00e9duction des niveaux de HSF2 a entra\u00een\u00e9 une baisse significative de l’expression des g\u00e8nes viraux. L’\u00e9quipe a \u00e9galement constat\u00e9 que HSF2 se lie aux g\u00e8nes viraux cl\u00e9s et aide \u00e0 rendre leur environnement de chromatine plus \u00abouvert\u00bb, permettant au virus d’activer ces g\u00e8nes plus facilement.<\/p>\n

\u00ab\u00a0Cette recherche r\u00e9sulte d’une collaboration avec le Sistonen Research Group, mettant en \u00e9vidence l’importance de la coop\u00e9ration synergique et du dialogue scientifique ouvert pour \u00e9tendre l’horizon des r\u00e9sultats scientifiques\u00a0\u00bb, explique Lorenza Cutrone, premier auteur de l’\u00e9tude et Ph.D. de la deuxi\u00e8me ann\u00e9e. \u00c9tudiant \u00e0 l’Universit\u00e9 \u00c5bo Akademi.<\/p>\n

Cette publication marque \u00e9galement la premi\u00e8re contribution scientifique du groupe de recherche virale Oncogen\u00e8se. L’\u00e9quipe rapporte positivement surprise par la rapidit\u00e9 avec laquelle le projet se r\u00e9unissait, d\u00e9crivant le r\u00e9sultat comme un d\u00e9but encourageant et stimulant pour leur parcours de recherche.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par l’Abo Akademi University<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une nouvelle \u00e9quipe de chercheurs de l’Universit\u00e9 \u00c5bo Akademi, dirig\u00e9e par la recherche de l’Acad\u00e9mie<\/p>\n","protected":false},"author":1,"featured_media":6135,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[311,391,1632,5099,604,49,1346,172,1033,763,630],"class_list":["post-6134","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-aide","tag-cancer","tag-decouvertes","tag-hsf2","tag-humaine","tag-les","tag-letude","tag-lies","tag-proteine","tag-reveiller","tag-virus","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLa prot\u00e9ine humaine HSF2 aide \u00e0 r\u00e9veiller les virus li\u00e9s au cancer, d\u00e9couvertes \u00e0 l'\u00e9tude - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/la-proteine-humaine-hsf2-aide-a-reveiller-les-virus-lies-au-cancer-decouvertes-a-letude\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La prot\u00e9ine humaine HSF2 aide \u00e0 r\u00e9veiller les virus li\u00e9s au cancer, d\u00e9couvertes \u00e0 l'\u00e9tude - 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