{"id":5961,"date":"2025-04-22T22:56:18","date_gmt":"2025-04-22T20:56:18","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/letude-placenta-acreta-trouve-linflammation-du-collagene-de-cicatrice-et-attire-les-cellules-placentaires-invasives\/"},"modified":"2025-04-22T22:56:19","modified_gmt":"2025-04-22T20:56:19","slug":"letude-placenta-acreta-trouve-linflammation-du-collagene-de-cicatrice-et-attire-les-cellules-placentaires-invasives","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/letude-placenta-acreta-trouve-linflammation-du-collagene-de-cicatrice-et-attire-les-cellules-placentaires-invasives\/","title":{"rendered":"L’\u00e9tude Placenta Acreta trouve l’inflammation du collag\u00e8ne de cicatrice et attire les cellules placentaires invasives"},"content":{"rendered":"
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Lorsqu’une cicatrice se d\u00e9veloppe \u00e0 partir de la chirurgie, des blessures ou de l’infection, le tissu environnant se transforme. Bien que la formation de cicatrices ait \u00e9t\u00e9 largement \u00e9tudi\u00e9e, moins est compris sur l’impact d’une nouvelle cicatrice dans le microenvironnement tissulaire.<\/p>\n

Kshitiz, professeur agr\u00e9g\u00e9 de g\u00e9nie biom\u00e9dical \u00e0 la UConn School of Dental Medicine, a examin\u00e9 de plus pr\u00e8s ce ph\u00e9nom\u00e8ne de tissu cicatriciel pour un article publi\u00e9 dans Communications de la nature<\/i>. Dans ses recherches, accompagn\u00e9es de l’\u00e9tudiant postdoctoral Wenqian Du, Kshitiz a \u00e9tudi\u00e9 les rares mais mortels de la vie maternelle placenta accr\u00e9ta, qui se produit lorsque le placenta se d\u00e9veloppe trop profond\u00e9ment dans la paroi ut\u00e9rine, pour faire la lumi\u00e8re sur les tissus cicatriciels.<\/p>\n

Les c\u00e9sariennes, qui entra\u00eenent des cicatrices ut\u00e9rines, sont effectu\u00e9es en nombre croissant. En parall\u00e8le, les cas de placenta accr\u00e9ta augmentent \u00e9galement. Le lien entre les cicatrices ut\u00e9rines et Placenta Accreta semble significative, ce qui a amen\u00e9 l’\u00e9quipe de recherche \u00e0 se demander comment les cicatrices peuvent d\u00e9clencher des propri\u00e9t\u00e9s invasives.<\/p>\n

La th\u00e9orie actuelle, selon les chercheurs, est que la cicatrice est comme une \u00ab\u00a0route vide\u00a0\u00bb et que le placenta se forme et se d\u00e9place dans la cicatrice. Kshitiz est sceptique quant \u00e0 cette th\u00e9orie debout.<\/p>\n

\u00ab\u00a0Nous l’avons remis en question parce que cela n’a aucun sens\u00a0\u00bb, explique Kshitiz. \u00ab\u00a0S’il s’agit d’une\u00a0\u00bb route vide \u00ab\u00a0, pourquoi les cellules usines de la m\u00e8re ne prennent-elles pas la route vide? Ce que nous avons constat\u00e9, c’est que ce n’est pas une route vide – la cicatrice est pleine de collag\u00e8ne.\u00a0\u00bb<\/p>\n

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Le collag\u00e8ne du tissu cicatriciel, selon les chercheurs, transforme l’endom\u00e8tre de la m\u00e8re en un \u00e9tat inflammatoire. \u00c0 l’aide de tissu ut\u00e9rine, les chercheurs ont cr\u00e9\u00e9 une matrice de cicatrice synth\u00e9tique qui imitait Placenta Accreta. Ils ont d\u00e9couvert que dans le cas de Placenta Accreta, un canal s’ouvre dans le tissu cicatriciel, provoquant un calcium pour infiltrer l’endom\u00e8tre et provoquer une inflammation. Lorsque l’inflammation se produit, des mol\u00e9cules sp\u00e9cifiques commencent \u00e0 recruter agressivement les cellules placentaires vers elles-m\u00eames de mani\u00e8re tr\u00e8s invasive.<\/p>\n

Les chercheurs ont d\u00e9sormais une meilleure compr\u00e9hension des implications des cicatrices, d\u00e9bloquant la possibilit\u00e9 de plus d’\u00e9tudes sur le tissu cicatriciel \u00e0 l’avenir.<\/p>\n

\u00ab\u00a0En tant que l’une des premi\u00e8res \u00e9tudes majeures sur la biologie de base du placenta accr\u00e9ta, cette d\u00e9couverte a ouvert un tout nouveau domaine o\u00f9 nous pouvons commencer \u00e0 poser des questions sur les implications des cicatrices\u00a0\u00bb, explique Kshitiz. \u00ab\u00a0En regardant Placenta Accreta, nous pouvons en apprendre davantage sur les processus invasifs caus\u00e9s par le tissu cicatriciel.\u00a0\u00bb<\/p>\n

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Lorsqu’une cicatrice se d\u00e9veloppe \u00e0 partir de la chirurgie, des blessures ou de l’infection, le<\/p>\n","protected":false},"author":1,"featured_media":5962,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[5006,5009,1622,5008,5007,1936,49,1346,1974,4161,5010,1456],"class_list":["post-5961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-acreta","tag-attire","tag-cellules","tag-cicatrice","tag-collagene","tag-invasives","tag-les","tag-letude","tag-linflammation","tag-placenta","tag-placentaires","tag-trouve","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nL'\u00e9tude Placenta Acreta trouve l'inflammation du collag\u00e8ne de cicatrice et attire les cellules placentaires invasives - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/letude-placenta-acreta-trouve-linflammation-du-collagene-de-cicatrice-et-attire-les-cellules-placentaires-invasives\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'\u00e9tude Placenta Acreta trouve l'inflammation du collag\u00e8ne de cicatrice et attire les cellules placentaires invasives - 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