{"id":5555,"date":"2025-04-06T10:55:54","date_gmt":"2025-04-06T08:55:54","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-souche-probiotique-savere-plus-efficace-pour-traiter-une-infection-intestinale-commune\/"},"modified":"2025-04-06T10:55:55","modified_gmt":"2025-04-06T08:55:55","slug":"une-nouvelle-souche-probiotique-savere-plus-efficace-pour-traiter-une-infection-intestinale-commune","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-souche-probiotique-savere-plus-efficace-pour-traiter-une-infection-intestinale-commune\/","title":{"rendered":"Une nouvelle souche probiotique s’av\u00e8re plus efficace pour traiter une infection intestinale commune"},"content":{"rendered":"
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La giardiase, caus\u00e9e par le protozoaire Giardia intestinalis, est la principale cause d’infections parasitaires intestinales chez l’homme et les animaux de compagnie, en particulier les chiens. Certains des principaux sympt\u00f4mes sont la diarrh\u00e9e, les douleurs abdominales, les naus\u00e9es et la perte de poids. De plus, cela peut entra\u00eener des complications post-infectieuses telles que le syndrome du c\u00f4lon irritable (IBS) et la fatigue chronique.<\/p>\n

Compte tenu de la r\u00e9sistance croissante du parasite aux traitements conventionnels (comme le nitroimidazole), les chercheurs explorent le potentiel de la souche probiotique Lactobacillus Johnsonii CNCM I-4884, brevet\u00e9e par Inrae, MNHN et ENVA en 2015. Cette bact\u00e9rie a une activit\u00e9 anti-Giardia significative, emp\u00eachant le parasite de d\u00e9velopper dans l’intime. Leur objectif est de d\u00e9velopper une nouvelle souche bact\u00e9rienne plus r\u00e9sistante aux processus digestifs, plus efficace contre le parasite et plus adapt\u00e9 \u00e0 la production industrielle.<\/p>\n

Les r\u00e9sultats sont publi\u00e9s dans la revue Microbes intestinaux<\/i>.<\/p>\n

Une nouvelle souche probiotique 15% plus efficace contre la giardiase<\/h2>\n

L. Johnsonii est une bact\u00e9rie naturellement pr\u00e9sente dans le microbiote intestinal. Pour r\u00e9sister \u00e0 la bile produite par le foie, cette bact\u00e9rie transforme les sels biliaires conjugu\u00e9s (qui sont essentiels pour la croissance du parasite G. intestinalis) en sels biliaires non conjugu\u00e9s, toxiques pour le parasite. Cette transformation des sels biliaires fait partie int\u00e9grante du processus digestif et a m\u00eame un effet anti-inflammatoire sur l’intestin.<\/p>\n

Les chercheurs ont recherch\u00e9 une am\u00e9lioration de la r\u00e9sistance de L. Johnsonii CNCM I-4884 aux sels biliaires en laboratoire, principalement en exposant la bact\u00e9rie \u00e0 des concentrations croissantes de sels biliaires. Apr\u00e8s leur processus de d\u00e9pistage, ils ont identifi\u00e9 la souche d\u00e9riv\u00e9e la plus prometteuse avec la plus grande activit\u00e9 de transformation du sel biliaire et la meilleure persistance pendant la culture.<\/p>\n

L’\u00e9quipe de recherche a test\u00e9 la souche bact\u00e9rienne s\u00e9lectionn\u00e9e dans un mod\u00e8le murin infect\u00e9 par G. intestinalis, en comparant les r\u00e9sultats avec ceux obtenus avec la souche de type sauvage. Les r\u00e9sultats montrent une r\u00e9duction de 64,4% de la charge parasitaire chez les animaux trait\u00e9s avec cette souche, contre 48,8% pour la souche de type sauvage. La souche d\u00e9riv\u00e9e de L. Johnsonii d\u00e9velopp\u00e9e par les chercheurs est donc 15% plus efficace contre la giardiase.<\/p>\n

Un m\u00e9dicament probiotique bas\u00e9 sur L. Johnsonii est dans les derniers stades des essais cliniques et devrait bient\u00f4t \u00eatre disponible pour les chiens. Les r\u00e9sultats de cette \u00e9tude ouvrent de nouvelles voies pour le d\u00e9veloppement de m\u00e9dicaments probiotiques pour lutter contre la giardiase chez les animaux, ainsi que chez l’homme, dans un avenir proche.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par Inrae – National Research Institute for Agriculture, Food and Environment<\/p>\n

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La giardiase, caus\u00e9e par le protozoaire Giardia intestinalis, est la principale cause d’infections parasitaires intestinales<\/p>\n","protected":false},"author":1,"featured_media":5556,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3375,206,1238,4753,244,8,4752,1639,1580,1165,47],"class_list":["post-5555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-commune","tag-efficace","tag-infection","tag-intestinale","tag-nouvelle","tag-pour","tag-probiotique","tag-savere","tag-souche","tag-traiter","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne nouvelle souche probiotique s'av\u00e8re plus efficace pour traiter une infection intestinale commune - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-souche-probiotique-savere-plus-efficace-pour-traiter-une-infection-intestinale-commune\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une nouvelle souche probiotique s'av\u00e8re plus efficace pour traiter une infection intestinale commune - 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