{"id":5306,"date":"2025-03-26T18:55:51","date_gmt":"2025-03-26T17:55:51","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/"},"modified":"2025-03-26T18:55:52","modified_gmt":"2025-03-26T17:55:52","slug":"letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/","title":{"rendered":"L’\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l’h\u00e9ro\u00efne"},"content":{"rendered":"
\n
\n
\n
\n<\/figure><\/div>\n<\/div>\n

Le trouble d’utilisation des opio\u00efdes est associ\u00e9 \u00e0 plus de 350 000 d\u00e9c\u00e8s par an dans le monde. Guid\u00e9s par la n\u00e9cessit\u00e9 d’une compr\u00e9hension accrue des caract\u00e9ristiques neurobiologiques critiques de la d\u00e9pendance, les chercheurs ont maintenant trouv\u00e9 une signature mol\u00e9culaire unique et des g\u00e8nes dans le cortex orbitofrontal associ\u00e9 \u00e0 un comportement de recherche d’h\u00e9ro\u00efne.<\/p>\n

Un mod\u00e8le pr\u00e9clinique de rongeurs a impliqu\u00e9 un g\u00e8ne appel\u00e9 Shisa7 comme pr\u00e9dicteur cl\u00e9. Une nouvelle \u00e9tude publi\u00e9e dans Psychiatrie biologique<\/i> Fournit des informations pr\u00e9cieuses sur les m\u00e9canismes neurobiologiques qui sous-tendent la d\u00e9pendance \u00e0 l’h\u00e9ro\u00efne et peuvent avoir des implications pour le d\u00e9veloppement de strat\u00e9gies innovantes pour lutter contre l’\u00e9pid\u00e9mie d’opio\u00efdes en cours.<\/p>\n

L’enqu\u00eateur principal Yasmin L. Hurd, Ph.D., D\u00e9partements de neurosciences et de psychiatrie, Friedman Brain Institute, ICAHN School of Medicine du Mount Sinai et Addiction Institute of Mount Sina\u00ef, New York, \u00ab\u00a0Mon \u00e9quipe de recherche et moi sommes amen\u00e9s \u00e0 \u00e9tendre les perspicaces neurobiologiques sous-jacentes \u00e0 la d\u00e9pendance.<\/p>\n

\u00ab\u00a0En examinant les signatures mol\u00e9culaires dans le cerveau des utilisateurs d’opio\u00efdes humains, nous esp\u00e9rons mieux comprendre la neuropathologie du trouble de la consommation d’opio\u00efdes au-del\u00e0 des m\u00e9canismes de r\u00e9compense aigus et d’identifier de nouvelles voies de traitement pertinentes pour les ph\u00e9notypes centraux qui perp\u00e9tuent la consommation de substances.\u00a0\u00bb<\/p>\n

Dans cette \u00e9tude, l’\u00e9quipe de recherche a appliqu\u00e9 l’apprentissage automatique pour distinguer la signature mol\u00e9culaire dans le cortex orbitofrontal, une r\u00e9gion du cerveau critique pour les aspects du contr\u00f4le des impulsions, le comportement de recherche de m\u00e9dicaments et les fonctions cognitives li\u00e9es aux troubles de la consommation de substances.<\/p>\n

Les enqu\u00eateurs ont constat\u00e9 que l’algorithme d’apprentissage automatique n’\u00e9tait pas seulement efficace pour identifier les signatures distinguant le cerveau d’un utilisateur d’h\u00e9ro\u00efne humain, mais il a \u00e9galement identifi\u00e9 le g\u00e8ne le plus pr\u00e9dictif de cette signature mol\u00e9culaire appel\u00e9e Shisa7 qui n’avait pas \u00e9t\u00e9 explor\u00e9e pr\u00e9c\u00e9demment dans le domaine. Une enqu\u00eate plus approfondie a r\u00e9v\u00e9l\u00e9 que la modulation de l’expression de ce g\u00e8ne dans le cortex orbitofrontal influence le comportement de recherche d’h\u00e9ro\u00efne et la flexibilit\u00e9 cognitive.<\/p>\n

Le Dr Hurd ajoute: \u00ab\u00a0Nous avons \u00e9galement observ\u00e9 que lorsque nous avons surexprim\u00e9 SHISA7 chez les animaux na\u00effs de m\u00e9dicaments, il a compl\u00e8tement issu la signature du transcriptome observ\u00e9e avec une utilisation r\u00e9p\u00e9t\u00e9e de l’h\u00e9ro\u00efne. Fait int\u00e9ressant, la signature de Shisa7 li\u00e9e \u00e0 une maladie neurod\u00e9g\u00e9n\u00e9rative et aux processus neuro-immunes.<\/p>\n

\u00ab\u00a0De plus, nous avons d\u00e9termin\u00e9 que les prot\u00e9ines qui se lient \u00e0 SHISA7 \u00e9taient li\u00e9es \u00e0 la fois au GABA (le neurotransmetteur inhibiteur primaire dans le syst\u00e8me nerveux central des mammif\u00e8res) et au glutamate (le primaire des neurotransmetteurs excitateurs dans les voies de la maladie neurod\u00e9g\u00e9naire centrale).\u00a0\u00bb<\/p>\n

L’auteur principal de l’\u00e9tude Randall Ellis, Ph.D., Department of Neuroscience and Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, et Addiction Institute of Mount Sinai, New York, qui met en \u00e9vidence le potentiel de notre approche de l’apprentissage automatique avanc\u00e9.<\/p>\n

\u00ab\u00a0L’application de l’apprentissage automatique de cette mani\u00e8re est exceptionnellement utile pour mieux comprendre les ensembles de donn\u00e9es \u00e0 haute dimension, tels que les milliers de g\u00e8nes captur\u00e9s par le s\u00e9quen\u00e7age d’ARN, pour d\u00e9couvrir de nouveaux mod\u00e8les dans l’expression des g\u00e8nes qui peuvent pr\u00e9dire efficacement les \u00e9tats pathologiques.<\/p>\n

\u00ab\u00a0Cette strat\u00e9gie dans la mise \u00e0 profit des donn\u00e9es des utilisateurs d’opio\u00efdes humains est particuli\u00e8rement importante car nous recherchons des strat\u00e9gies innovantes pour lutter contre l’\u00e9pid\u00e9mie d’opio\u00efdes en cours. De plus, nos r\u00e9sultats mettent en \u00e9vidence les risques potentiels \u00e0 long terme de l’utilisation d’opio\u00efdes pour les maladies neurod\u00e9g\u00e9n\u00e9ratives futures.\u00a0\u00bb<\/p>\n

John Krystal, MD, r\u00e9dacteur en chef de Biological Psychiatry, a d\u00e9clar\u00e9: \u00ab\u00a0Cette \u00e9tude met en \u00e9vidence la biologie complexe du trouble de la consommation d’opio\u00efdes. Des \u00e9tudes minutieuses des tissus c\u00e9r\u00e9braux post-mortem, en utilisant des analyses guid\u00e9es par l’IA, sont essentielles pour identifier les \u00e9l\u00e9ments de construction mol\u00e9culaire de la toxicomanie. Il est int\u00e9ressant qu’une cible identifi\u00e9e dans ce processus, soit \u00e9galement une augmentation des animaux.<\/p>\n

Le Dr Hurd conclut: \u00ab\u00a0Ces r\u00e9sultats de translation mettent en \u00e9vidence l’importance d’\u00e9tudier le cerveau humain, qui peut aider \u00e0 d\u00e9couvrir de nouveaux syst\u00e8mes biologiques sous-jacents au trouble qui pourrait finalement ouvrir de nouvelles avenues de traitement.\u00a0\u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Le trouble d’utilisation des opio\u00efdes est associ\u00e9 \u00e0 plus de 350 000 d\u00e9c\u00e8s par an<\/p>\n","protected":false},"author":1,"featured_media":5307,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[666,1674,410,1617,1049,1346,4616,4615,4614],"class_list":["post-5306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-cle","tag-comme","tag-dependance","tag-gene","tag-identifie","tag-letude","tag-lheroine","tag-moteur","tag-shisa7","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nL'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"Le trouble d’utilisation des opio\u00efdes est associ\u00e9 \u00e0 plus de 350 000 d\u00e9c\u00e8s par an\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\" \/>\n<meta property=\"og:site_name\" content=\"RVH-Synergie\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-26T17:55:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-26T17:55:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"554\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Charles Martinez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Charles Martinez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\"},\"author\":{\"name\":\"Charles Martinez\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\"},\"headline\":\"L’\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l’h\u00e9ro\u00efne\",\"datePublished\":\"2025-03-26T17:55:51+00:00\",\"dateModified\":\"2025-03-26T17:55:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\"},\"wordCount\":830,\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg\",\"keywords\":[\"cl\u00e9\",\"comme\",\"d\u00e9pendance\",\"g\u00e8ne\",\"identifie\",\"L\u00e9tude\",\"lh\u00e9ro\u00efne\",\"moteur\",\"Shisa7\"],\"articleSection\":[\"Les addictions\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\",\"name\":\"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne - RVH-Synergie.org\",\"isPartOf\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg\",\"datePublished\":\"2025-03-26T17:55:51+00:00\",\"dateModified\":\"2025-03-26T17:55:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg\",\"width\":2560,\"height\":554,\"caption\":\"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/rvh-synergie.org\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"L’\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l’h\u00e9ro\u00efne\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#website\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"name\":\"RVH-Synergie.org\",\"description\":\"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.\",\"publisher\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#organization\",\"name\":\"RVH-Synergie.org\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png\",\"width\":512,\"height\":512,\"caption\":\"RVH-Synergie.org\"},\"image\":{\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560\",\"name\":\"Charles Martinez\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"contentUrl\":\"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg\",\"caption\":\"Charles Martinez\"},\"description\":\"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.\",\"sameAs\":[\"https:\/\/rvh-synergie.org\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne - RVH-Synergie.org","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/","og_locale":"fr_FR","og_type":"article","og_title":"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne - RVH-Synergie.org","og_description":"Le trouble d’utilisation des opio\u00efdes est associ\u00e9 \u00e0 plus de 350 000 d\u00e9c\u00e8s par an","og_url":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/","og_site_name":"RVH-Synergie","article_published_time":"2025-03-26T17:55:51+00:00","article_modified_time":"2025-03-26T17:55:52+00:00","og_image":[{"width":2560,"height":554,"url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg","type":"image\/jpeg"}],"author":"Charles Martinez","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Charles Martinez","Dur\u00e9e de lecture estim\u00e9e":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#article","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/"},"author":{"name":"Charles Martinez","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560"},"headline":"L’\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l’h\u00e9ro\u00efne","datePublished":"2025-03-26T17:55:51+00:00","dateModified":"2025-03-26T17:55:52+00:00","mainEntityOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/"},"wordCount":830,"publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg","keywords":["cl\u00e9","comme","d\u00e9pendance","g\u00e8ne","identifie","L\u00e9tude","lh\u00e9ro\u00efne","moteur","Shisa7"],"articleSection":["Les addictions"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/","url":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/","name":"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne - RVH-Synergie.org","isPartOf":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#website"},"primaryImageOfPage":{"@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage"},"thumbnailUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg","datePublished":"2025-03-26T17:55:51+00:00","dateModified":"2025-03-26T17:55:52+00:00","breadcrumb":{"@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#primaryimage","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2025\/03\/1743011751_Letude-identifie-le-gene-Shisa7-comme-un-moteur-cle-de-scaled.jpg","width":2560,"height":554,"caption":"L'\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l'h\u00e9ro\u00efne"},{"@type":"BreadcrumbList","@id":"https:\/\/rvh-synergie.org\/actualites\/letude-identifie-le-gene-shisa7-comme-un-moteur-cle-de-la-dependance-a-lheroine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/rvh-synergie.org\/actualites\/"},{"@type":"ListItem","position":2,"name":"L’\u00e9tude identifie le g\u00e8ne Shisa7 comme un moteur cl\u00e9 de la d\u00e9pendance \u00e0 l’h\u00e9ro\u00efne"}]},{"@type":"WebSite","@id":"https:\/\/rvh-synergie.org\/actualites\/#website","url":"https:\/\/rvh-synergie.org\/actualites\/","name":"RVH-Synergie.org","description":"RVH-Synergie, site ind\u00e9pendant d'informations sur la prise en charge des addictions.","publisher":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rvh-synergie.org\/actualites\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/rvh-synergie.org\/actualites\/#organization","name":"RVH-Synergie.org","url":"https:\/\/rvh-synergie.org\/actualites\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/favicon.png","width":512,"height":512,"caption":"RVH-Synergie.org"},"image":{"@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/aa5ea98671fb4e8620f488a0795d2560","name":"Charles Martinez","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/rvh-synergie.org\/actualites\/#\/schema\/person\/image\/","url":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","contentUrl":"https:\/\/rvh-synergie.org\/actualites\/wp-content\/uploads\/2024\/09\/charles-martinez-scaled.jpg","caption":"Charles Martinez"},"description":"Bonjour, je m'appelle Charles Martinez, r\u00e9dacteur passionn\u00e9 pour le m\u00e9dia RVH-synergie.org, d\u00e9di\u00e9 aux addictions et aux maladies. Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. Mon engagement r\u00e9side dans l'espoir de cr\u00e9er une communaut\u00e9 inform\u00e9e et empathique, pr\u00eate \u00e0 soutenir ceux qui luttent contre ces \u00e9preuves.","sameAs":["https:\/\/rvh-synergie.org\/"]}]}},"_links":{"self":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/5306","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/comments?post=5306"}],"version-history":[{"count":0,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/posts\/5306\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media\/5307"}],"wp:attachment":[{"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/media?parent=5306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/categories?post=5306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rvh-synergie.org\/actualites\/wp-json\/wp\/v2\/tags?post=5306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}