{"id":4934,"date":"2025-03-11T09:58:36","date_gmt":"2025-03-11T08:58:36","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/linfection-intranasale-de-lherpes-peut-produire\/"},"modified":"2025-03-11T09:58:37","modified_gmt":"2025-03-11T08:58:37","slug":"linfection-intranasale-de-lherpes-peut-produire","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/linfection-intranasale-de-lherpes-peut-produire\/","title":{"rendered":"L’infection intranasale de l’herp\u00e8s peut produire"},"content":{"rendered":"
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Le virus-1 de l’herp\u00e8s simplex (HSV-1) est commun\u00e9ment connu pour provoquer des cloques et des plaies. Mais dans certains cas, le virus peut migrer vers l’\u0153il ou le syst\u00e8me nerveux, provoquant des sympt\u00f4mes graves et chroniques.<\/p>\n

Maintenant, une \u00e9tude des chercheurs de l’Universit\u00e9 de l’Illinois Chicago constate que l’infection \u00e0 l’herp\u00e8s par le nez peut entra\u00eener une anxi\u00e9t\u00e9, des troubles moteurs et des probl\u00e8mes cognitifs. La recherche est la premi\u00e8re \u00e0 montrer qu’en exploitant une enzyme cellulaire, le virus peut produire des sympt\u00f4mes comportementaux. La constatation souligne la n\u00e9cessit\u00e9 de pr\u00e9vention et de traitement d’un virus transport\u00e9 par des milliards de personnes dans le monde.<\/p>\n

La recherche, publi\u00e9e dans MBIO<\/i>est le dernier du Coll\u00e8ge de m\u00e9decine dirig\u00e9 par Deepak Shukla, le Marion H. Schenk Esq. Professeur en ophtalmologie pour la recherche sur l’\u0153il vieillissant et professeur UIC de microbiologie et d’immunologie.<\/p>\n

Le laboratoire de Shukla a pr\u00e9c\u00e9demment \u00e9tudi\u00e9 comment le virus se propage \u00e0 l’\u0153il et au cerveau et peut conduire \u00e0 la c\u00e9cit\u00e9, \u00e0 l’enc\u00e9phalite et \u00e0 d’autres conditions. La nouvelle recherche a examin\u00e9 l’infection intranasale, o\u00f9 les particules virales p\u00e9n\u00e8trent dans le corps par le nez et ont un acc\u00e8s plus direct au syst\u00e8me nerveux.<\/p>\n

\u00ab\u00a0Si un individu infect\u00e9 perd le virus via des larmes, il pourrait atteindre la cavit\u00e9 nasale, o\u00f9 elle pourrait aller plus directement au cerveau\u00a0\u00bb, a d\u00e9clar\u00e9 Shukla. \u00ab\u00a0Je pense que c’est sous-diagnostiqu\u00e9 et sous-\u00e9tudi\u00e9, mais les cons\u00e9quences neurologiques, selon nous, sont beaucoup plus graves que vous ne le verriez normalement avec des cloques de fi\u00e8vre ou une infection oculaire.\u00a0\u00bb<\/p>\n

Dans les exp\u00e9riences d’animaux, les chercheurs ont observ\u00e9 des niveaux \u00e9lev\u00e9s d’inflammation et de dommages neuronaux quelques jours seulement apr\u00e8s l’infection par le HSV-1. Pendant plusieurs mois apr\u00e8s – \u00e9quivalents \u00e0 des d\u00e9cennies de vie chez l’homme – les animaux infect\u00e9s ont permis de mieux les tests de coordination motrice et de m\u00e9moire et ont montr\u00e9 un comportement plus anxi\u00e9t\u00e9 par rapport aux t\u00e9moins.<\/p>\n

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\u00ab\u00a0Il y a certainement des l\u00e9sions nerveuses si vous empruntez la voie intranasale, et les effets sont \u00e0 long terme, ce qui est alarmant\u00a0\u00bb, a d\u00e9clar\u00e9 Shukla.<\/p>\n

Les chercheurs ont \u00e9galement \u00e9tudi\u00e9 l’h\u00e9paranase, une enzyme cellulaire que le groupe avait pr\u00e9c\u00e9demment \u00e9tudi\u00e9e pour son r\u00f4le dans la r\u00e9infection HSV-1 et les effets \u00e0 long terme. Les animaux avec un g\u00e8ne d\u00e9sactiv\u00e9 pour l’h\u00e9paranase n’ont pas montr\u00e9 les m\u00eames d\u00e9ficits neuro -haviores apr\u00e8s infection que les animaux t\u00e9moins. Cela sugg\u00e8re que l’enzyme assure la m\u00e9diation de certains des effets dommageables du virus dans le cerveau.<\/p>\n

\u00ab\u00a0Ces informations ouvrent la porte \u00e0 des approches th\u00e9rapeutiques potentielles pour att\u00e9nuer les effets de la neuroinflammation et pr\u00e9venir les l\u00e9sions c\u00e9r\u00e9brales \u00e0 long terme caus\u00e9es par des infections virales\u00a0\u00bb, a d\u00e9clar\u00e9 Hemant Borase, chercheur postdoctoral UIC et premier auteur de l’\u00e9tude.<\/p>\n

Le virus-1 de l’herp\u00e8s simplex est extr\u00eamement courant. L’Organisation mondiale de la sant\u00e9 estime que pr\u00e8s des deux tiers de la population mondiale portent le virus.<\/p>\n

\u00ab\u00a0Le virus r\u00e9active tout au long de la vie; c’est une infection \u00e0 vie\u00a0\u00bb, a d\u00e9clar\u00e9 Chandrashekhar Patil, professeur adjoint de recherche au College of Medicine et co-auteur du journal. \u00ab\u00a0Donc, je pense que cette conscience sera vraiment importante parmi la grande population qui porte ce virus.\u00a0\u00bb<\/p>\n

Tibor Valyi-Nagy, professeur de pathologie, est \u00e9galement co-auteur de l’article.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Le virus-1 de l’herp\u00e8s simplex (HSV-1) est commun\u00e9ment connu pour provoquer des cloques et des<\/p>\n","protected":false},"author":1,"featured_media":4935,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[4413,1625,539,669,829],"class_list":["post-4934","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-intranasale","tag-lherpes","tag-linfection","tag-peut","tag-produire","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nL'infection intranasale de l'herp\u00e8s peut produire - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/linfection-intranasale-de-lherpes-peut-produire\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'infection intranasale de l'herp\u00e8s peut produire - 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