{"id":466,"date":"2024-09-15T23:17:01","date_gmt":"2024-09-15T21:17:01","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-dose-de-vaccin-contre-la-variole-sest-revelee-moderement-efficace-pour-prevenir-linfection-par-le-mpox\/"},"modified":"2024-09-15T23:17:11","modified_gmt":"2024-09-15T21:17:11","slug":"une-dose-de-vaccin-contre-la-variole-sest-revelee-moderement-efficace-pour-prevenir-linfection-par-le-mpox","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-dose-de-vaccin-contre-la-variole-sest-revelee-moderement-efficace-pour-prevenir-linfection-par-le-mpox\/","title":{"rendered":"Une dose de vaccin contre la variole s’est r\u00e9v\u00e9l\u00e9e mod\u00e9r\u00e9ment efficace pour pr\u00e9venir l’infection par le mpox"},"content":{"rendered":"
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Une dose du vaccin antivariolique modifi\u00e9 Ankara-Bavarian Nordic (MVA-BN) est mod\u00e9r\u00e9ment efficace pour pr\u00e9venir l’infection par le mpox et devrait \u00eatre mise \u00e0 la disposition des communaut\u00e9s \u00e0 risque, selon une \u00e9tude publi\u00e9e par Le BMJ<\/i> .<\/p>\n

Alors que les infections \u00e0 mpox augmentent \u00e0 nouveau dans le monde, les chercheurs affirment que ces r\u00e9sultats \u00ab renforcent les preuves que le MVA-BN est efficace pour pr\u00e9venir l’infection \u00e0 mpox et devrait \u00eatre mis \u00e0 disposition et accessible aux communaut\u00e9s \u00e0 risque \u00bb.<\/p>\n

Aucun essai clinique randomis\u00e9 de vaccination contre le mpox n’a \u00e9t\u00e9 men\u00e9. Les estimations de l’efficacit\u00e9 d’une dose unique de vaccination issues d’\u00e9tudes observationnelles varient de 36 % \u00e0 86 %, mais les donn\u00e9es observationnelles peuvent \u00eatre sujettes \u00e0 des biais, ce qui peut conduire \u00e0 des r\u00e9sultats inexacts ou trompeurs.<\/p>\n

Pour r\u00e9soudre ce probl\u00e8me, les chercheurs ont entrepris d\u2019estimer l\u2019efficacit\u00e9 r\u00e9elle d\u2019une dose de MVA-BN contre l\u2019infection par le mpox en utilisant une technique appel\u00e9e \u00e9mulation d\u2019essai cible. Cette technique applique les principes de conception des essais randomis\u00e9s aux donn\u00e9es observationnelles pour estimer l\u2019effet causal d\u2019une intervention, tout en r\u00e9duisant les biais courants dans les \u00e9tudes observationnelles.<\/p>\n

Leurs conclusions sont bas\u00e9es sur des hommes \u00e2g\u00e9s d\u2019au moins 18 ans, ayant subi des tests de d\u00e9pistage de la syphilis et d\u2019une infection sexuellement transmissible bact\u00e9rienne (IST) confirm\u00e9e en laboratoire au cours de l\u2019ann\u00e9e pr\u00e9c\u00e9dente, ou ayant rempli une ordonnance pour un traitement pr\u00e9ventif contre le VIH au cours de l\u2019ann\u00e9e pr\u00e9c\u00e9dente.<\/p>\n

Au total, 3 204 hommes vaccin\u00e9s ont \u00e9t\u00e9 compar\u00e9s \u00e0 3 204 t\u00e9moins non vaccin\u00e9s. Au cours de la p\u00e9riode d’\u00e9tude de 153 jours, 71 infections \u00e0 mpox ont \u00e9t\u00e9 diagnostiqu\u00e9es, 21 dans le groupe vaccin\u00e9 (un taux de 0,09 pour 1 000 jours-personnes) et 50 dans le groupe non vaccin\u00e9 (un taux de 0,20 pour 1 000 jours-personnes).<\/p>\n

Le risque relatif d’infection dans le groupe vaccin\u00e9 par rapport au groupe non vaccin\u00e9 \u00e9tait de 0,42, donc l’efficacit\u00e9 estim\u00e9e du vaccin d’une dose de MVA-BN contre l’infection par le mpox \u00e9tait de 58 %.<\/p>\n

Les chercheurs reconnaissent que l’appariement rigoureux a conduit \u00e0 un \u00e9chantillon plus petit et qu’ils n’ont pas pu \u00e9valuer un sch\u00e9ma \u00e0 deux doses ou la dur\u00e9e de la protection. Les informations sur la vaccination antivariolique ant\u00e9rieure, les expositions sexuelles et les mesures individuelles des d\u00e9terminants sociaux de la sant\u00e9 manquaient \u00e9galement.<\/p>\n

Toutefois, les r\u00e9sultats sont bas\u00e9s sur des donn\u00e9es fiables provenant d\u2019un syst\u00e8me de sant\u00e9 financ\u00e9 par l\u2019\u00c9tat et sont similaires apr\u00e8s une analyse plus approfondie visant \u00e0 tenir compte d\u2019autres facteurs potentiellement influents, ce qui renforce la confiance dans les conclusions.<\/p>\n

Les chercheurs concluent donc qu’en l’absence d’essais cliniques randomis\u00e9s, \u00ab nos r\u00e9sultats renforcent les preuves selon lesquelles le MVA-BN est efficace pour pr\u00e9venir l’infection \u00e0 mpox et devrait \u00eatre mis \u00e0 disposition et accessible aux communaut\u00e9s \u00e0 risque. \u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une dose du vaccin antivariolique modifi\u00e9 Ankara-Bavarian Nordic (MVA-BN) est mod\u00e9r\u00e9ment efficace pour pr\u00e9venir l’infection<\/p>\n","protected":false},"author":1,"featured_media":467,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[90,534,206,539,537,324,540,8,538,536,535,47,323,303],"class_list":["post-466","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-contre","tag-dose","tag-efficace","tag-linfection","tag-moderement","tag-mpox","tag-par","tag-pour","tag-prevenir","tag-revelee","tag-sest","tag-une","tag-vaccin","tag-variole","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne dose de vaccin contre la variole s'est r\u00e9v\u00e9l\u00e9e mod\u00e9r\u00e9ment efficace pour pr\u00e9venir l'infection par le mpox - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-dose-de-vaccin-contre-la-variole-sest-revelee-moderement-efficace-pour-prevenir-linfection-par-le-mpox\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une dose de vaccin contre la variole s'est r\u00e9v\u00e9l\u00e9e mod\u00e9r\u00e9ment efficace pour pr\u00e9venir l'infection par le mpox - 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