{"id":4407,"date":"2025-02-18T14:55:53","date_gmt":"2025-02-18T13:55:53","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/letude-met-en-lumiere-la-facon-dont-ladn-des-gens-affecte-leur-reponse-au-medicament-a-larret-du-tabac\/"},"modified":"2025-02-18T14:55:54","modified_gmt":"2025-02-18T13:55:54","slug":"letude-met-en-lumiere-la-facon-dont-ladn-des-gens-affecte-leur-reponse-au-medicament-a-larret-du-tabac","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/letude-met-en-lumiere-la-facon-dont-ladn-des-gens-affecte-leur-reponse-au-medicament-a-larret-du-tabac\/","title":{"rendered":"L’\u00e9tude met en lumi\u00e8re la fa\u00e7on dont l’ADN des gens affecte leur r\u00e9ponse au m\u00e9dicament \u00e0 l’arr\u00eat du tabac"},"content":{"rendered":"
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L’efficacit\u00e9 d’une drogue commune pour arr\u00eater de fumer pourrait \u00eatre d\u00fb aux g\u00e8nes des gens, selon une \u00e9tude de l’Universit\u00e9 de Leicester (Royaume-Uni).<\/p>\n

Le vanenicline est largement reconnu comme le m\u00e9dicament le plus efficace pour aider les gens \u00e0 arr\u00eater de fumer, mais malheureusement, cela ne fonctionne pas pour tout le monde.<\/p>\n

Des chercheurs de Leicester ont r\u00e9v\u00e9l\u00e9 des informations importantes sur la fa\u00e7on dont l’ADN des gens affecte leur r\u00e9ponse au m\u00e9dicament, qui sera bient\u00f4t disponible pour les fumeurs par le biais du National Health Service (NHS) du Royaume-Uni.<\/p>\n

La var\u00e9nicline fonctionne en ciblant des r\u00e9cepteurs sp\u00e9cifiques dans le cerveau pour bloquer les effets enrichissants du tabagisme et r\u00e9duire les envies.<\/p>\n

Une \u00e9quipe internationale de chercheurs a d\u00e9velopp\u00e9 une m\u00e9thode pour utiliser des dossiers de sant\u00e9 \u00e9lectroniques pour identifier les personnes qui ont r\u00e9ussi \u00e0 arr\u00eater de fumer avec la var\u00e9nicline et ceux qui ne l’ont pas fait.<\/p>\n

La m\u00e9thode a \u00e9t\u00e9 appliqu\u00e9e aux dossiers de sant\u00e9 des habitants du Leicestershire et de Rutland, dans les Midlands, au Royaume-Uni, qui font partie de l’\u00e9tude Exceed (cohorte \u00e9tendue pour la sant\u00e9, l’environnement et l’ADN). La m\u00e9thode a \u00e9galement \u00e9t\u00e9 mise en \u0153uvre dans d’autres \u00e9tudes de cohorte nationales et internationales, qui ont \u00e9galement collect\u00e9 des donn\u00e9es g\u00e9n\u00e9tiques.<\/p>\n

Dans la plus grande \u00e9tude de ce type \u00e0 ce type, l’\u00e9quipe de recherche a effectu\u00e9 une analyse g\u00e9n\u00e9tique pour d\u00e9terminer si les diff\u00e9rences dans le code g\u00e9n\u00e9tique des individus pourraient expliquer pourquoi le succ\u00e8s du traitement de la var\u00e9nicline varie.<\/p>\n

L’\u00e9tude, publi\u00e9e dans Recherche de nicotine et de tabac<\/i>des variantes g\u00e9n\u00e9tiques individuelles d\u00e9couvertes (petites diff\u00e9rences dans la s\u00e9quence d’ADN) li\u00e9es \u00e0 l’arr\u00eat du tabagisme \u00e0 l’aide de var\u00e9nicline. Les variantes g\u00e9n\u00e9tiques identifi\u00e9es mettent en \u00e9vidence l’implication des g\u00e8nes dans la r\u00e9gulation de l’activit\u00e9 des g\u00e8nes et dans la fonction des extensions de cheveux des cellules, appel\u00e9es cils.<\/p>\n

La version de marque de Varenicline, Champix, n’est pas disponible depuis 2021 en raison d’une impuret\u00e9 de fabrication. Cependant, \u00e0 la fin de 2024, il a \u00e9t\u00e9 annonc\u00e9 qu’une version g\u00e9n\u00e9rique de la var\u00e9nicline a \u00e9t\u00e9 approuv\u00e9e et est en train d’\u00eatre r\u00e9introduite dans le NHS.<\/p>\n

Le Dr Kayesha Coley, chercheur principal de l’\u00e9tude, a d\u00e9clar\u00e9: \u00ab\u00a0Notre \u00e9tude est la premi\u00e8re \u00e0 scanner l’ensemble du g\u00e9nome \u00e0 rechercher des g\u00e8nes li\u00e9s \u00e0 l’arr\u00eat avec succ\u00e8s de fumer en utilisant la var\u00e9nicline. Les g\u00e8nes nous donnent des informations utiles sur les divers processus biologiques en jeu, Mais la prochaine \u00e9tape consiste \u00e0 confirmer nos r\u00e9sultats avec des \u00e9tudes encore plus grandes.<\/p>\n

La Dre Catherine John, directrice scientifique de Department, a d\u00e9clar\u00e9: \u00ab\u00a0Le tabagisme est toujours l’un des plus grands tueurs au Royaume-Uni et dans le monde, et plus de la moiti\u00e9 des fumeurs disent qu’ils veulent quitter. La recherche sur la fa\u00e7on de soutenir les gens \u00e0 arr\u00eater de fumer est essentielle, Et des \u00e9tudes comme Exc\u00e9der jouent un r\u00f4le important dans ce domaine.<\/p>\n

L’\u00e9quipe de recherche a soulign\u00e9 l’importance des \u00e9tudes continues dans ce domaine pour approfondir comment la g\u00e9n\u00e9tique influence le succ\u00e8s de la var\u00e9nicline et am\u00e9liore davantage la compr\u00e9hension biologique.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

L’efficacit\u00e9 d’une drogue commune pour arr\u00eater de fumer pourrait \u00eatre d\u00fb aux g\u00e8nes des gens,<\/p>\n","protected":false},"author":1,"featured_media":4408,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[1366,16,1875,546,520,1172,153,1346,353,831,1046,815,326,154],"class_list":["post-4407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-affecte","tag-des","tag-dont","tag-facon","tag-gens","tag-ladn","tag-larret","tag-letude","tag-leur","tag-lumiere","tag-medicament","tag-met","tag-reponse","tag-tabac","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nL'\u00e9tude met en lumi\u00e8re la fa\u00e7on dont l'ADN des gens affecte leur r\u00e9ponse au m\u00e9dicament \u00e0 l'arr\u00eat du tabac - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/letude-met-en-lumiere-la-facon-dont-ladn-des-gens-affecte-leur-reponse-au-medicament-a-larret-du-tabac\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L'\u00e9tude met en lumi\u00e8re la fa\u00e7on dont l'ADN des gens affecte leur r\u00e9ponse au m\u00e9dicament \u00e0 l'arr\u00eat du tabac - 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