{"id":4271,"date":"2025-02-13T09:55:58","date_gmt":"2025-02-13T08:55:58","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/nouveau-trouble-de-la-contraction-sanguine-identifiee\/"},"modified":"2025-02-13T09:55:58","modified_gmt":"2025-02-13T08:55:58","slug":"nouveau-trouble-de-la-contraction-sanguine-identifiee","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/nouveau-trouble-de-la-contraction-sanguine-identifiee\/","title":{"rendered":"Nouveau trouble de la contraction sanguine identifi\u00e9e"},"content":{"rendered":"
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Les chercheurs de l’Universit\u00e9 McMaster ont fait une d\u00e9couverte dans le domaine de l’h\u00e9matologie, fournissant une explication des obstacles sanguins spontan\u00e9s et inhabituels qui continuent de se produire malgr\u00e9 le traitement avec des anticoagulants \u00e0 dose compl\u00e8te.<\/p>\n

The Discovery, publi\u00e9 le 12 f\u00e9vrier 2025 The New England Journal of Medicine<\/i>devrait influencer la fa\u00e7on dont les m\u00e9decins testent et traitent les patients atteints de coagulation sanguine inhabituelle ou r\u00e9currente, avec le potentiel d’am\u00e9liorer les r\u00e9sultats des patients.<\/p>\n

Les chercheurs ont constat\u00e9 que ce nouveau trouble de coagulation sanguine pr\u00e9sente certaines similitudes avec la thrombocytop\u00e9nie et la thrombose immunitaires induites par les vaccins – un trouble de coagulation rare mais agressif qui a \u00e9t\u00e9 caus\u00e9 par certains vaccins Covid-19 discontinus.<\/p>\n

La recherche r\u00e9v\u00e8le que certains patients peuvent d\u00e9velopper une coagulation sanguine s\u00e9v\u00e8re en raison d’anticorps qui ressemblent \u00e9troitement \u00e0 ceux qui provoquent le VITT, m\u00eame en l’absence de d\u00e9clencheurs connus pour de tels anticorps, tels que les anticoagulants (h\u00e9parine) ou la vaccination ant\u00e9rieure.<\/p>\n

Le trouble nouvellement identifi\u00e9 a \u00e9t\u00e9 appel\u00e9 gammopathie monoclonale de type VITT de signification thrombotique (MGT).<\/p>\n

\u00ab\u00a0Notre \u00e9tude met en \u00e9vidence l’importance de reconna\u00eetre et de diagnostiquer ce nouveau trouble de la coagulation sanguine\u00a0\u00bb, a d\u00e9clar\u00e9 Theodore (TED) Warkentin, co-premier auteur et auteur correspondant de l’\u00e9tude et professeur \u00e9m\u00e9rite au D\u00e9partement de pathologie et de m\u00e9decine mol\u00e9culaire de l’Universit\u00e9 McMaster.<\/p>\n

\u00ab\u00a0En comprenant comment diagnostiquer les MGT de type VITT, nous pouvons d\u00e9velopper des strat\u00e9gies de traitement plus efficaces qui vont au-del\u00e0 de l’anticoagulation traditionnelle\u00a0\u00bb, a d\u00e9clar\u00e9 Warkentin, h\u00e9matologue au D\u00e9partement de m\u00e9decine bas\u00e9 \u00e0 l’h\u00f4pital g\u00e9n\u00e9ral de Hamilton General de Hamilton Health Sciences.<\/p>\n

Des tests sp\u00e9cialis\u00e9s ont \u00e9t\u00e9 effectu\u00e9s au McMaster Platelet Immunology Laboratory au sein du Michael G. DeGroote Center for Transfusion Research, le seul laboratoire au Canada avec le r\u00e9pertoire complet des tests n\u00e9cessaires pour caract\u00e9riser les anticorps de type VITT qui ciblent la prot\u00e9ine PF4.<\/p>\n

Les chercheurs ont effectu\u00e9 une analyse d\u00e9taill\u00e9e des cas pr\u00e9sentant un obstacle sanguin inhabituel malgr\u00e9 le fait que les patients soient sous anticoagulants \u00e0 dose compl\u00e8te, en se concentrant sur les patients qui avaient des anticorps de type VITT inexpliqu\u00e9s qui \u00e9taient d\u00e9tectables pendant un an ou plus.<\/p>\n

Les analyses ont identifi\u00e9 la pr\u00e9sence de prot\u00e9ines M (monoclonales) (qui indiquent g\u00e9n\u00e9ralement des troubles du plasmat), et avec les r\u00e9activit\u00e9s persistantes de type VITT sur au moins 12 mois (ce qui est tr\u00e8s inhabituel pour la plupart des anticorps anti-PF4), pointant ainsi de pointer de point un processus pathologique continu plut\u00f4t qu’une anomalie \u00e0 court terme.<\/p>\n

L’\u00e9tude comprenait une collaboration multinationale, avec des donn\u00e9es collect\u00e9es aupr\u00e8s de cinq patients trait\u00e9s dans des institutions au Canada, en Nouvelle-Z\u00e9lande, en France, en Espagne et en Allemagne.<\/p>\n

Le collaborateur Jing Jing Wang de l’Universit\u00e9 Flinders en Australie a jou\u00e9 un r\u00f4le crucial dans la prouvance pour chaque patient que les prot\u00e9ines M sont les anticorps pathologiques de type VITT. Le collaborateur Andreas Greinacher de l’Universit\u00e9 Greifswald en Allemagne a aid\u00e9 \u00e0 identifier des cas similaires dans son laboratoire de r\u00e9f\u00e9rence anti-PF4.<\/p>\n

\u00ab\u00a0Les r\u00e9sultats de cette \u00e9tude soulignent notre capacit\u00e9 \u00e0 tirer parti de la science mol\u00e9culaire et biochimique fondamentale pour d\u00e9m\u00ealer les m\u00e9canismes de maladies\u00a0\u00bb, a d\u00e9clar\u00e9 Ishac Nazy, co-auteur de l’\u00e9tude et directeur scientifique du McMaster Platelet Immunology Laboratory et codirecteur du Michael G G. .<\/p>\n

\u00ab\u00a0Cette approche permet un diagnostic pr\u00e9cis des patients et informe les strat\u00e9gies de traitement en temps opportun, m\u00eame pour les maladies non identifi\u00e9es auparavant, illustrant la v\u00e9ritable m\u00e9decine translationnelle du banc \u00e0 coucher\u00a0\u00bb, a d\u00e9clar\u00e9 Nazy, professeur agr\u00e9g\u00e9 au D\u00e9partement de m\u00e9decine de McMaster.<\/p>\n

Une observation remarquable a \u00e9t\u00e9 que chacun des patients avait \u00e9chou\u00e9 un traitement d’amincissement sanguin, mais ils ont montr\u00e9 un certain avantage avec des traitements inhabituels, tels que les immunoglobulines intraveineuses \u00e0 forte dose (IVIG), les inhibiteurs de la my\u00e9roth\u00e9rapie par myeloma par cellule de bruton tyrosine kinase (ibrutinib) et plasmatique \u00e0 cellules plasmatiques (ibrutinib) et plasmatique \u00e0 cellules en plasma et en plasma (ibrutinib) et en plasma par cellules plasmatiques \u00e0 cellules plasmatiques (Ibrutinib) et plasmatique \u00e0 cellules en plasma par cellules plasmatiques (ibrutinib) et plasmatique \u00e0 cellules plasmatiques \u00e0 cellules plasmatiques (ibrutinib) et plasmatique par cellules par cellules en plasma .<\/p>\n

L’existence de ce nouveau trouble du coagulation sanguine a des implications importantes sur la fa\u00e7on dont les prestataires de soins de sant\u00e9 \u00e9valueront les patients qui d\u00e9veloppent des caillots sanguins inhabituels ou difficiles \u00e0 traiter \u00e0 l’avenir.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Les chercheurs de l’Universit\u00e9 McMaster ont fait une d\u00e9couverte dans le domaine de l’h\u00e9matologie, fournissant<\/p>\n","protected":false},"author":1,"featured_media":599,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[4004,2705,495,735,781],"class_list":["post-4271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-contraction","tag-identifiee","tag-nouveau","tag-sanguine","tag-trouble","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nNouveau trouble de la contraction sanguine identifi\u00e9e - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/nouveau-trouble-de-la-contraction-sanguine-identifiee\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nouveau trouble de la contraction sanguine identifi\u00e9e - 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