{"id":4259,"date":"2025-02-13T01:57:33","date_gmt":"2025-02-13T00:57:33","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/sattaquer-a-la-menace-de-coli-resistante-a-la-drogue-en-chine\/"},"modified":"2025-02-13T01:57:34","modified_gmt":"2025-02-13T00:57:34","slug":"sattaquer-a-la-menace-de-coli-resistante-a-la-drogue-en-chine","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/sattaquer-a-la-menace-de-coli-resistante-a-la-drogue-en-chine\/","title":{"rendered":"S’attaquer \u00e0 la menace d’E. Coli r\u00e9sistante \u00e0 la drogue en Chine"},"content":{"rendered":"
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Une \u00e9tude compl\u00e8te de sept ans dans 20 provinces chinoises a r\u00e9v\u00e9l\u00e9 une augmentation pr\u00e9occupante de la r\u00e9sistance aux antimicrobiens (AMR) chez les Escherichia coli diarrh\u00e9g\u00e9nique (E. coli), un agent pathog\u00e8ne d’origine alimentaire majeure. Analysant 9 068 isolats de cas de diarrh\u00e9e humaine sporadique, la recherche dressant une image troublante: la majorit\u00e9 des isolats sont r\u00e9sistants \u00e0 au moins un agent antimicrobien, beaucoup d\u00e9montrant une r\u00e9sistance multidrude. Ces r\u00e9sultats sont essentiels pour fa\u00e7onner les strat\u00e9gies de traitement des antibiotiques cliniques et la hi\u00e9rarchisation des efforts pour limiter la propagation de la r\u00e9sistance.<\/p>\n

E. coli diarrh\u00e9g\u00e9nique (DEC) est une cause globale majeure de maladies diarrh\u00e9iques, certaines souches montrant des niveaux alarmants de r\u00e9sistance aux antibiotiques. La mont\u00e9e de ces souches r\u00e9sistantes a rendu de nombreux traitements de premi\u00e8re ligne inefficace, compliquant consid\u00e9rablement la gestion de cas de diarrh\u00e9e s\u00e9v\u00e8res et prolong\u00e9s.<\/p>\n

La surutilisation g\u00e9n\u00e9ralis\u00e9e des antibiotiques a acc\u00e9l\u00e9r\u00e9 encore l’\u00e9mergence de souches multir\u00e9sistantes (MDR), qui sont r\u00e9sistantes \u00e0 un large spectre d’antibiotiques. Dans ce contexte, la recherche continue est essentielle pour surveiller et att\u00e9nuer la propagation de l’AMR en d\u00e9cembre.<\/p>\n

L’\u00e9tude publi\u00e9e dans Une sant\u00e9 progressive<\/i> Le 30 octobre 2024, met en \u00e9vidence la pr\u00e9occupation croissante de la RAM dans E. coli diarrh\u00e9ique en Chine. Dirig\u00e9 par des chercheurs du China National Center for Food Safety Risk Assessment and Provincial Research Centers, l’\u00e9tude a analys\u00e9 les isolats d’E. Coli de 2016 \u00e0 2022, fournissant des informations pr\u00e9cieuses sur les sch\u00e9mas de r\u00e9sistance en \u00e9volution.<\/p>\n

Au cours de la p\u00e9riode d’\u00e9tude de sept ans, les chercheurs ont analys\u00e9 9 068 DEC recueillis dans des cas de diarrh\u00e9e humaine sporadique dans 20 provinces chinoises. Les r\u00e9sultats \u00e9taient frappants: 89,3% des isolats \u00e9taient r\u00e9sistants \u00e0 au moins un agent antimicrobien, 60,3% pr\u00e9sentant une r\u00e9sistance multidrogue.<\/p>\n

Notamment, la r\u00e9sistance \u00e0 l’ampicilline a \u00e9t\u00e9 trouv\u00e9e dans 68,2% des isolats, tandis que la r\u00e9sistance \u00e0 l’imip\u00e9n\u00e8me est rest\u00e9e relativement faible \u00e0 1,6%. De plus, la r\u00e9sistance \u00e0 la c\u00e9foxitine et au chloramph\u00e9nicol a d\u00e9montr\u00e9 une tendance \u00e0 la hausse concernant.<\/p>\n

Le pathotype pr\u00e9dominant \u00e9tait E. coli ent\u00e9roagr\u00e9gatif (EAEC), repr\u00e9sentant 47,3% des isolats, avec des variations notables de la r\u00e9sistance entre diff\u00e9rents groupes d’\u00e2ge, en particulier les nourrissons de moins d’un an, qui ont montr\u00e9 une r\u00e9sistance plus \u00e9lev\u00e9e \u00e0 plusieurs antibiotiques. Ces profils de r\u00e9sistance d\u00e9taill\u00e9s fournissent des informations critiques pour affiner les strat\u00e9gies de traitement clinique et mettent en \u00e9vidence le besoin urgent d’interventions cibl\u00e9es pour freiner la propagation des souches r\u00e9sistantes.<\/p>\n

Le Dr Yunchang Guo, le chercheur principal, a soulign\u00e9 l’importance d’une surveillance continue et des efforts proactifs pour r\u00e9soudre le probl\u00e8me croissant de l’AMR. \u00ab\u00a0Nos r\u00e9sultats soulignent le besoin urgent de r\u00e9glementations antibiotiques plus strictes chez l’homme et le b\u00e9tail, ainsi que l’adoption d’une approche\u00a0\u00bb une sant\u00e9 \u00ab\u00a0pour minimiser l’impact des infections \u00e0 l’origine alimentaire caus\u00e9es par le DEC r\u00e9sistant\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Guo.<\/p>\n

Les implications de cette recherche sont une grande port\u00e9e, fournissant des donn\u00e9es essentielles aux cliniciens et aux d\u00e9cideurs pour d\u00e9velopper des traitements et des strat\u00e9gies efficaces contre les infections DEC. Les taux de r\u00e9sistance particuli\u00e8rement \u00e9lev\u00e9s chez les nourrissons mettent en \u00e9vidence le besoin critique de surveillance continue de l’AMR en Chine. Cette \u00e9tude soutient les efforts plus larges pour prot\u00e9ger la sant\u00e9 publique en relevant le d\u00e9fi mondial de l’AMR et en promouvant les actions interdisciplinaires pour emp\u00eacher la propagation des agents pathog\u00e8nes r\u00e9sistants.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par la Chine Universit\u00e9 agricole<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9tude compl\u00e8te de sept ans dans 20 provinces chinoises a r\u00e9v\u00e9l\u00e9 une augmentation pr\u00e9occupante<\/p>\n","protected":false},"author":1,"featured_media":4260,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[1659,2017,292,1179,1581,3774],"class_list":["post-4259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-chine","tag-coli","tag-drogue","tag-menace","tag-resistante","tag-sattaquer","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nS'attaquer \u00e0 la menace d'E. 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Depuis plus de dix ans, j'explore et rapporte les histoires poignantes des individus confront\u00e9s \u00e0 ces d\u00e9fis, tout en sensibilisant le public aux traitements novateurs et aux progr\u00e8s scientifiques dans ce domaine. 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