{"id":4061,"date":"2025-02-05T02:56:15","date_gmt":"2025-02-05T01:56:15","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/questions-detude-la-reputation-addictive-de-la-dexamphetamine\/"},"modified":"2025-02-05T02:56:29","modified_gmt":"2025-02-05T01:56:29","slug":"questions-detude-la-reputation-addictive-de-la-dexamphetamine","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/questions-detude-la-reputation-addictive-de-la-dexamphetamine\/","title":{"rendered":"Questions d’\u00e9tude La r\u00e9putation addictive de la dexamph\u00e9tamine"},"content":{"rendered":"
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La dexamph\u00e9tamine – un m\u00e9dicament stimulant restreint utilis\u00e9 pour traiter la narcolepsie et le trouble d’hyperactivit\u00e9 d\u00e9ficient en l’attention (TDAH) – ne peut pas \u00eatre aussi addictif qu’on le pensait pr\u00e9c\u00e9demment, de nouvelles recherches de l’Universit\u00e9 de Sydney sugg\u00e8rent.<\/p>\n

Dans une revue narrative, publi\u00e9e dans Psychoactifs<\/i>une \u00e9quipe de chercheurs a examin\u00e9 plus de 1 700 articles pour \u00e9valuer les preuves qui sous-tendent la classification de la dexamph\u00e9tamine en tant que m\u00e9dicament restreint. \u00c9tonnamment, l’\u00e9quipe de recherche n’a constat\u00e9 que sept articles n’avaient pas r\u00e9pondu directement \u00e0 la d\u00e9pendance \u00e0 la dexamph\u00e9tamine, avec seulement quatre cas individuels possibles de d\u00e9pendance d\u00e9taill\u00e9s.<\/p>\n

L’auteur principal, la Dre Alison Poulton, ma\u00eetre de conf\u00e9rences en p\u00e9diatrie et en sant\u00e9 infantile \u00e0 la Nepean Clinical School, a d\u00e9clar\u00e9 que l’\u00e9tude soul\u00e8ve des questions sur les \u00e9l\u00e9ments de preuve qui sous-tendent sa restriction par la th\u00e9rapeutique Administration des produits (TGA) et la Food and Drug Administration (FDA).<\/p>\n

\u00ab\u00a0Apr\u00e8s avoir effectu\u00e9 un examen complet des preuves disponibles, il est surprenant que nous n’ayons pu trouver qu’une poign\u00e9e de cas potentiels de d\u00e9pendance \u00e0 la dexamph\u00e9tamine document\u00e9s.<\/p>\n

\u00ab\u00a0La dexamph\u00e9tamine est bien connue comme un m\u00e9dicament efficace dans le traitement du TDAH et de la narcolepsie – mais il est \u00e9galement connu pour avoir des avantages possibles dans le traitement d’autres conditions, y compris l’ob\u00e9sit\u00e9, o\u00f9 il a le potentiel d’\u00eatre une alternative \u00e0 moindre co\u00fbt \u00e0 d’autres des m\u00e9dicaments, tels que le s\u00e9maglutide (ozempique et Wegovy) et le tirz\u00e9patide (Mounjaro).<\/p>\n

\u00ab\u00a0Il est important que nous appliquons une rigueur scientifique dans l’\u00e9valuation des risques potentiels des m\u00e9dicaments pharmaceutiques, en particulier lorsqu’ils pourraient avoir des avantages significatifs pour les patients\u00a0\u00bb, explique Poulton.<\/p>\n

L’\u00e9tude a \u00e9t\u00e9 r\u00e9alis\u00e9e en recherchant des recherches pertinentes sur PubMed, Scopus et Embase en utilisant les mots cl\u00e9s \u00abdexamph\u00e9tamine\u00bb, \u00abd\u00e9pendance\u00bb et \u00abd\u00e9pendance\u00bb. L’\u00e9quipe de recherche a examin\u00e9 les articles \u00e9crits en anglais et les types d’\u00e9tudes \u00e9valu\u00e9es comprenaient des rapports de cas, des audits de base de donn\u00e9es, des \u00e9tudes de cohorte, des essais de contr\u00f4le randomis\u00e9s (RCT) et des revues syst\u00e9matiques.<\/p>\n

La dexamph\u00e9tamine \u00e9tait largement utilis\u00e9e \u00e0 partir des ann\u00e9es 1950 pour traiter des conditions telles que l’asthme, la d\u00e9pression et une vari\u00e9t\u00e9 de troubles psychiatriques, et s’est \u00e9galement r\u00e9v\u00e9l\u00e9 \u00eatre un m\u00e9dicament utile pour la gestion du poids.<\/p>\n

Cependant, en 1962, un article publi\u00e9 dans le Revue m\u00e9dicale britannique<\/i> Pr\u00e9sent\u00e9 des preuves de d\u00e9pendance \u00e0 la dexamph\u00e9tamine, avec psychose et perturbation psychiatrique signal\u00e9es chez les patients hospitalis\u00e9s \u00e0 la suite de fortes doses de m\u00e9dicament.<\/p>\n

En cons\u00e9quence, la FDA a limit\u00e9 l’utilisation des amph\u00e9tamines, ce qui leur permet de poursuivre le traitement de la narcolepsie et du TDAH, mais les interdisant efficacement d’\u00eatre utilis\u00e9s dans le traitement de la d\u00e9pression, des conditions psychiatriques et de l’ob\u00e9sit\u00e9.<\/p>\n

Pour mieux en savoir plus sur le potentiel addictif de la dexamph\u00e9tamine, l’\u00e9quipe de recherche r\u00e9alise une \u00e9tude suppl\u00e9mentaire sur le nombre de personnes admises dans des centres de m\u00e9dicaments avec des d\u00e9pendances au stimulant sur ordonnance.<\/p>\n

L’\u00e9quipe du Dr Poulton r\u00e9alise \u00e9galement un essai clinique utilisant la dexamph\u00e9tamine pour traiter l’ob\u00e9sit\u00e9. L’essai \u00e9valuera \u00e9galement si le m\u00e9dicament montre un potentiel addictif \u00e0 la posologie prescrite.<\/p>\n

Le premier auteur Hazer Khalifa, un doctorat. Le candidat de la Facult\u00e9 de m\u00e9decine et de la sant\u00e9 et des chercheurs impliqu\u00e9s dans l’essai clinique, a d\u00e9clar\u00e9: \u00ab\u00a0L’ob\u00e9sit\u00e9 est un probl\u00e8me de sant\u00e9 majeur qui affecte des millions de personnes dans le monde. Si l’essai clinique sugg\u00e8re que la dexamph\u00e9tamine peut \u00eatre utilis\u00e9e dans le traitement de l’ob\u00e9sit\u00e9 sans causer de d\u00e9pendance , alors cela pourrait \u00eatre un outil important bon march\u00e9 pour les cliniciens afin d’aider les gens \u00e0 g\u00e9rer un exc\u00e8s de poids. \u00ab\u00a0<\/p>\n

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La dexamph\u00e9tamine – un m\u00e9dicament stimulant restreint utilis\u00e9 pour traiter la narcolepsie et le trouble<\/p>\n","protected":false},"author":1,"featured_media":4062,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[3868,3866,3869,1223,3867],"class_list":["post-4061","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-addictive","tag-detude","tag-dexamphetamine","tag-questions","tag-reputation","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nQuestions d'\u00e9tude La r\u00e9putation addictive de la dexamph\u00e9tamine - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/questions-detude-la-reputation-addictive-de-la-dexamphetamine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Questions d'\u00e9tude La r\u00e9putation addictive de la dexamph\u00e9tamine - 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