{"id":3940,"date":"2025-01-31T05:56:23","date_gmt":"2025-01-31T04:56:23","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/la-methode-predit-lefficacite-de-la-therapie-de-la-tuberculose\/"},"modified":"2025-01-31T05:56:25","modified_gmt":"2025-01-31T04:56:25","slug":"la-methode-predit-lefficacite-de-la-therapie-de-la-tuberculose","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/la-methode-predit-lefficacite-de-la-therapie-de-la-tuberculose\/","title":{"rendered":"La m\u00e9thode pr\u00e9dit l’efficacit\u00e9 de la th\u00e9rapie de la tuberculose"},"content":{"rendered":"
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Les souches \u00e9mergentes r\u00e9sistantes aux m\u00e9dicaments posent des d\u00e9fis importants \u00e0 la lutte mondiale contre la tuberculose (TB) et il est essentiel de d\u00e9tecter l’\u00e9chec du traitement le plus t\u00f4t possible.<\/p>\n

Des chercheurs du Marius Nasta Institute (MNI) et du Borstel du Centre de recherche, Leibniz Lung Center (FZB) ont maintenant \u00e9valu\u00e9 un nouveau test pour la d\u00e9tection pr\u00e9coce des changements dans la charge bact\u00e9rienne de Mycobacterium tuberculosis, ce qui fournit une indication du succ\u00e8s du traitement en quelques heures . Les r\u00e9sultats de l’\u00e9tude sont publi\u00e9s dans le Journal of Infection<\/i>.<\/p>\n

La tuberculose est une infection bact\u00e9rienne caus\u00e9e par Mycobacterium tuberculosis. Il affecte principalement les poumons et reste l’une des maladies infectieuses les plus meurtri\u00e8res du monde, en particulier dans ses formes r\u00e9sistantes \u00e0 la drogue. Les m\u00e9thodes actuelles de suivi de la tuberculose pulmonaire, la forme la plus courante de la maladie, reposent sur la microscopie \u00e0 frottis d’expectorations, les tests d’amplification de l’ADN et les cultures de M. tuberculosis.<\/p>\n

Cependant, ces approches ont des limitations notables. La microscopie, bien que rapide et rentable, a du mal \u00e0 faire la distinction entre les bact\u00e9ries vivantes et mortes et a une faible sensibilit\u00e9. Les tests d’amplification de l’ADN, tels que Genexpert, peuvent donner des r\u00e9sultats faux positifs pour les patients qui ont r\u00e9ussi \u00e0 terminer le traitement. Les cultures, consid\u00e9r\u00e9es comme l’\u00e9talon-or, sont exactes mais n\u00e9cessitent des semaines pour les r\u00e9sultats.<\/p>\n

Dans le cadre d’un projet de recherche entre le Centre de recherche Borstel, Leibniz Lung Center et le Marius Nasta Institute (MNI) \u00e0 Bucarest, en Roumanie, le doctorat m\u00e9dical Marit Neumann de l’Universit\u00e9 de L\u00fcbeck a travaill\u00e9 pendant deux ans pour \u00e9valuer un nouveau test pour les premiers D\u00e9tection des changements de la charge bact\u00e9rienne chez les patients infect\u00e9s par M. tuberculosis r\u00e9sistant aux m\u00e9dicaments.<\/p>\n

Ce test, le test de charge bact\u00e9rienne mol\u00e9culaire (MBLA), repr\u00e9sente un nouvel outil innovant pour surveiller le traitement TB. Le test mesure M. tuberculosis 16S RRNA, un marqueur des bact\u00e9ries viables, par la transcriptase inverse PCR.<\/p>\n

\u00ab\u00a0Contrairement aux m\u00e9thodes traditionnelles, la MBLA fournit des r\u00e9sultats au lieu de semaines, rationalisant le processus de surveillance, qui est extr\u00eamement important pour la tuberculose r\u00e9sistante aux m\u00e9dicaments\u00a0\u00bb, explique Neumann, premier auteur de l’\u00e9tude.<\/p>\n

Pour valider ce test pour suivre la r\u00e9ponse au traitement des patients atteints de tuberculose r\u00e9sistante au m\u00e9dicament, les chercheurs du Centre de recherche Borstel ont men\u00e9 une \u00e9tude sur des patients en Roumanie avec un multidrogue (MDR \/ RR) et largement r\u00e9sistant aux m\u00e9dicaments (pr\u00e9-XDR \/ XDR ) TB. Les patients de cette cohorte ont \u00e9t\u00e9 surveill\u00e9s chaque semaine par microscopie, Genexpert, Culture et MBLA, fournissant des donn\u00e9es riches pour une analyse comparative.<\/p>\n

\u00ab\u00a0La MBLA a d\u00e9montr\u00e9 une excellente concordance avec les r\u00e9sultats de la culture, en particulier dans les premiers stades du traitement. Contrairement \u00e0 tous les autres tests de diagnostic, la MBLA a pu identifier clairement les changements pr\u00e9coces de la charge bact\u00e9rienne chez les patients r\u00e9sistants au m\u00e9dicament pendant le traitement\u00a0\u00bb, explique Neumann des r\u00e9sultats . \u00ab\u00a0Par cons\u00e9quent, le test MBLA offre une alternative sans culture avec une pr\u00e9cision comparable \u00e0 la microscopie et une pr\u00e9cision sup\u00e9rieure sur les tests d’amplification d’ADN comme Genexpert.\u00a0\u00bb<\/p>\n

Les r\u00e9sultats soulignent le potentiel de la MBLA \u00e0 transformer la gestion de la tuberculose en r\u00e9duisant consid\u00e9rablement le temps \u00e0 r\u00e9sulter pour \u00e9valuer la r\u00e9ponse au traitement. Cet outil est sur le point d’am\u00e9liorer les soins aux patients et d’acc\u00e9l\u00e9rer l’\u00e9valuation de nouveaux m\u00e9dicaments anti-TB dans les essais cliniques en phase pr\u00e9coce.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par Forschungszentrum Borstel, Leibniz Lungenzentrum<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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