{"id":3518,"date":"2025-01-15T05:56:40","date_gmt":"2025-01-15T04:56:40","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/la-salive-active-la-coagulation-chez-les-patients-atteints-dhemophilie-a-selon-une-etude\/"},"modified":"2025-01-15T05:56:42","modified_gmt":"2025-01-15T04:56:42","slug":"la-salive-active-la-coagulation-chez-les-patients-atteints-dhemophilie-a-selon-une-etude","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/la-salive-active-la-coagulation-chez-les-patients-atteints-dhemophilie-a-selon-une-etude\/","title":{"rendered":"La salive active la coagulation chez les patients atteints d\u2019h\u00e9mophilie A, selon une \u00e9tude"},"content":{"rendered":"
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Une \u00e9tude r\u00e9cente men\u00e9e par MedUni Vienne apporte de nouvelles informations sur les m\u00e9canismes de coagulation chez les personnes atteintes d’h\u00e9mophilie A, la forme d’h\u00e9mophilie la plus courante. L’\u00e9quipe de recherche a pu montrer que la salive contient des v\u00e9sicules sp\u00e9ciales qui d\u00e9clenchent une coagulation rapide du sang des patients h\u00e9mophiles. Les r\u00e9sultats, r\u00e9cemment publi\u00e9s dans la revue Sang<\/i>contribuent de mani\u00e8re significative \u00e0 une meilleure compr\u00e9hension de la maladie.<\/p>\n

L’h\u00e9mophilie est une maladie sanguine h\u00e9r\u00e9ditaire caract\u00e9ris\u00e9e par un d\u00e9ficit de certains facteurs de coagulation, qui peut entra\u00eener des saignements potentiellement mortels si elle n’est pas trait\u00e9e. La raison pour laquelle l’h\u00e9mophilie A (avec d\u00e9ficit en facteur VIII) entra\u00eene souvent des saignements articulaires, mais rarement des saignements des muqueuses, n’\u00e9tait pas claire auparavant.<\/p>\n

\u00c0 la recherche d’une explication, l’\u00e9quipe scientifique dirig\u00e9e par Johannes Thaler et Cihan Ay (Division clinique d’h\u00e9matologie et d’h\u00e9mostaseologie, D\u00e9partement de m\u00e9decine I, MedUni Vienne) et Rienk Nieuwland (Centres m\u00e9dicaux universitaires d’Amsterdam) a \u00e9tudi\u00e9 la recherche sur l’importance du corps. liquides pour la coagulation sanguine, oubli\u00e9s depuis des d\u00e9cennies.<\/p>\n

Les chercheurs ont d\u00e9couvert que la salive des patients h\u00e9mophiles A contient des complexes de tenase extrins\u00e8ques, situ\u00e9s sur des v\u00e9sicules. Les complexes de tenase extrins\u00e8ques sont des complexes prot\u00e9iques constitu\u00e9s de deux facteurs de coagulation (facteur tissulaire TF et facteur VIIa) et qui d\u00e9clenchent l’activation de la cascade de coagulation lorsqu’ils entrent en contact avec le sang.<\/p>\n

Les analyses des auteurs de l\u2019\u00e9tude confirment que les saignements de la muqueuse buccale de ces patients sont effectivement rares et s\u2019arr\u00eatent rapidement. Les patients sans ce complexe prot\u00e9ique dans leur salive ne disposent pas de ce m\u00e9canisme de protection. \u00ab\u00a0Ils souffrent donc souvent de saignements de la muqueuse buccale\u00a0\u00bb, rapporte Thaler.<\/p>\n

Les fluides corporels comme activateurs de la coagulation sanguine<\/h2>\n

L\u2019importance des fluides corporels pour la coagulation a \u00e9t\u00e9 d\u00e9crite pour la premi\u00e8re fois dans les ann\u00e9es 1930. \u00c0 cette \u00e9poque, l\u2019esp\u00e9rance de vie moyenne des patients h\u00e9mophiles n\u2019\u00e9tait que de huit ans. Le p\u00e9diatre viennois Alphons Sol\u00e9 a d\u00e9couvert que le lait maternel est un puissant activateur de la coagulation. Dans une \u00e9tude clinique, il a montr\u00e9 que les tamponnades imbib\u00e9es de lait maternel stoppaient rapidement les saignements aigus, auparavant imparables, chez les patients h\u00e9mophiles.<\/p>\n

Mais les d\u00e9couvertes de Sol\u00e9, confirm\u00e9es par des chercheurs ind\u00e9pendants, ont \u00e9t\u00e9 oubli\u00e9es. Il y a seulement quelques ann\u00e9es, l’\u00e9quipe dirig\u00e9e par Thaler, Ay et Nieuwland a relanc\u00e9 ces recherches historiques. Les scientifiques ont pu prouver que les propri\u00e9t\u00e9s favorisant la coagulation du lait maternel, du liquide amniotique, de l\u2019urine \u2013 et d\u00e9sormais aussi de la salive \u2013 sont dues \u00e0 la pr\u00e9sence de v\u00e9sicules extracellulaires contenant des complexes t\u00e9nases extrins\u00e8ques.<\/p>\n

Les r\u00e9sultats fournissent des informations importantes sur les m\u00e9canismes de la coagulation et contribuent \u00e0 une meilleure compr\u00e9hension de l’h\u00e9mophilie A. \u00ab En m\u00eame temps, ils montrent qu’il peut \u00eatre tr\u00e8s enrichissant de r\u00e9\u00e9valuer les travaux scientifiques historiques afin de d\u00e9velopper des approches innovantes de recherche et potentiellement \u00e9galement pour le traitement cibl\u00e9 des patients\u00a0\u00bb, explique Thaler.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9tude r\u00e9cente men\u00e9e par MedUni Vienne apporte de nouvelles informations sur les m\u00e9canismes de<\/p>\n","protected":false},"author":1,"featured_media":3519,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[3198,282,56,3497,1066,48,49,616,3496,46,47],"class_list":["post-3518","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-active","tag-atteints","tag-chez","tag-coagulation","tag-dhemophilie","tag-etude","tag-les","tag-patients","tag-salive","tag-selon","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLa salive active la coagulation chez les patients atteints d\u2019h\u00e9mophilie A, selon une \u00e9tude - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/la-salive-active-la-coagulation-chez-les-patients-atteints-dhemophilie-a-selon-une-etude\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La salive active la coagulation chez les patients atteints d\u2019h\u00e9mophilie A, selon une \u00e9tude - 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