{"id":3507,"date":"2025-01-14T22:01:45","date_gmt":"2025-01-14T21:01:45","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/mutation-genetique-liee-a-un-risque-plus-eleve-de-sras-cov-2\/"},"modified":"2025-01-14T22:01:55","modified_gmt":"2025-01-14T21:01:55","slug":"mutation-genetique-liee-a-un-risque-plus-eleve-de-sras-cov-2","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/mutation-genetique-liee-a-un-risque-plus-eleve-de-sras-cov-2\/","title":{"rendered":"Mutation g\u00e9n\u00e9tique li\u00e9e \u00e0 un risque plus \u00e9lev\u00e9 de SRAS-CoV-2"},"content":{"rendered":"
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Les chercheurs ont identifi\u00e9 un nouveau facteur de risque g\u00e9n\u00e9tique pour l’infection par le SRAS-CoV-2, fournissant ainsi de nouvelles informations sur la capacit\u00e9 du virus \u00e0 envahir les cellules humaines. Le SRAS-CoV-2 est le virus qui propage le COVID-19.<\/p>\n

L’\u00e9tude, dirig\u00e9e par l’immunologiste Declan McCole de l’Universit\u00e9 de Californie \u00e0 Riverside, montre qu’une variante de perte de fonction du g\u00e8ne PTPN2 de la phosphatase, g\u00e9n\u00e9ralement associ\u00e9e aux maladies auto-immunes, peut augmenter l’expression du r\u00e9cepteur ACE2 du SRAS-CoV-2, rendant les cellules plus sensibles \u00e0 l\u2019invasion virale.<\/p>\n

L’article, intitul\u00e9 \u00ab Tofacitinib att\u00e9nue la susceptibilit\u00e9 accrue \u00e0 l’infection par le SRAS-CoV-2 caus\u00e9e par une variante du risque de MII dans le g\u00e8ne PTPN2 \u00bb, est publi\u00e9 dans la revue Gastro-ent\u00e9rologie et h\u00e9patologie cellulaire et mol\u00e9culaire<\/i>.<\/p>\n

Une variante avec perte de fonction est une modification g\u00e9n\u00e9tique qui perturbe le fonctionnement normal d’une prot\u00e9ine, l’inactivant ou l’alt\u00e9rant gravement. ACE2, une prot\u00e9ine pr\u00e9sente \u00e0 la surface de nombreux types de cellules, agit comme r\u00e9cepteur du virus SARS-CoV-2 et lui permet d’infecter les cellules.<\/p>\n

\u00ab\u00a0Nos r\u00e9sultats sugg\u00e8rent que les personnes pr\u00e9sentant une activit\u00e9 PTPN2 r\u00e9duite pourraient \u00eatre confront\u00e9es \u00e0 un risque plus \u00e9lev\u00e9 d’infection en raison de la r\u00e9gulation positive de l’ACE2, qui sert de point d’entr\u00e9e au SRAS-CoV-2 dans les cellules humaines\u00a0\u00bb, a d\u00e9clar\u00e9 McCole, professeur de sciences biom\u00e9dicales \u00e0 l’\u00c9cole de m\u00e9decine UCR.<\/p>\n

\u00ab\u00a0PTPN2, qui est exprim\u00e9 dans les cellules de tout le corps, \u00e9limine normalement un phosphate d’autres prot\u00e9ines et enzymes, r\u00e9duisant ainsi leur activit\u00e9. Il agit comme un frein. Si vous avez une perte de fonction dans PTPN2, alors le frein ne fonctionne pas. eh bien, et vous obtenez plus de signaux inflammatoires.<\/p>\n

La d\u00e9couverte offre une compr\u00e9hension plus approfondie de la fa\u00e7on dont les facteurs g\u00e9n\u00e9tiques influencent la susceptibilit\u00e9 au COVID-19 et sugg\u00e8re des pistes th\u00e9rapeutiques potentielles pour att\u00e9nuer ce risque. L\u2019\u00e9tude a utilis\u00e9 des tissus intestinaux humains, des cellules humaines et des mod\u00e8les de souris.<\/p>\n

McCole a expliqu\u00e9 qu’en identifiant PTPN2 comme un nouveau facteur g\u00e9n\u00e9tique, l’\u00e9quipe de recherche a d\u00e9couvert une voie critique qui peut influencer la fa\u00e7on dont le corps r\u00e9agit \u00e0 l’infection par le SRAS-CoV-2.<\/p>\n

\u00ab\u00a0Nous montrons qu’une variante de ce g\u00e8ne, associ\u00e9e depuis longtemps \u00e0 des maladies auto-immunes, peut rendre certaines cellules plus vuln\u00e9rables au virus\u00a0\u00bb, a-t-il d\u00e9clar\u00e9. \u00ab\u00a0Notre \u00e9tude montre \u00e9galement que ce risque peut \u00eatre att\u00e9nu\u00e9 avec le Tofacitinib, un inhibiteur de JAK largement utilis\u00e9, offrant de nouvelles options de traitement potentielles pour les patients pr\u00e9sentant un risque g\u00e9n\u00e9tique plus \u00e9lev\u00e9. Le Tofacitinib, approuv\u00e9 pour traiter la colite ulc\u00e9reuse, a invers\u00e9 l’expression accrue de l’ACE2 dans les poumons, les intestins, et les cellules immunitaires, r\u00e9duisant ainsi la susceptibilit\u00e9 \u00e0 l’invasion virale.<\/p>\n

Les inhibiteurs de la Janus kinase (JAK) constituent une classe de m\u00e9dicaments largement utilis\u00e9s pour traiter les maladies inflammatoires chroniques et les maladies \u00e0 m\u00e9diation immunitaire.<\/p>\n

\u00ab\u00a0La capacit\u00e9 du tofacitinib \u00e0 r\u00e9duire l’expression de l’ACE2 et \u00e0 abaisser la sensibilit\u00e9 des cellules immunitaires au virus pourrait \u00eatre essentielle pour lutter plus efficacement contre la pand\u00e9mie, en particulier chez les populations vuln\u00e9rables\u00a0\u00bb, a d\u00e9clar\u00e9 McCole. \u00ab Nos d\u00e9couvertes jettent les bases d’autres essais cliniques visant \u00e0 explorer le potentiel th\u00e9rapeutique des inhibiteurs de JAK dans la pr\u00e9vention ou le traitement de l’infection par le SRAS-CoV-2, ainsi qu’\u00e0 offrir de nouvelles informations sur les interactions complexes entre le syst\u00e8me immunitaire, la g\u00e9n\u00e9tique et la susceptibilit\u00e9 virale. \u00ab\u00a0<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Les chercheurs ont identifi\u00e9 un nouveau facteur de risque g\u00e9n\u00e9tique pour l’infection par le SRAS-CoV-2,<\/p>\n","protected":false},"author":1,"featured_media":3508,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[105,944,664,3287,40,1913],"class_list":["post-3507","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-eleve","tag-genetique","tag-liee","tag-mutation","tag-risque","tag-srascov2","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nMutation g\u00e9n\u00e9tique li\u00e9e \u00e0 un risque plus \u00e9lev\u00e9 de SRAS-CoV-2 - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/mutation-genetique-liee-a-un-risque-plus-eleve-de-sras-cov-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mutation g\u00e9n\u00e9tique li\u00e9e \u00e0 un risque plus \u00e9lev\u00e9 de SRAS-CoV-2 - 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