{"id":3398,"date":"2025-01-10T01:56:13","date_gmt":"2025-01-10T00:56:13","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/pour-les-femmes-atteintes-de-sclerose-en-plaques-la-mobilite-recule-a-la-menopause\/"},"modified":"2025-01-10T01:56:15","modified_gmt":"2025-01-10T00:56:15","slug":"pour-les-femmes-atteintes-de-sclerose-en-plaques-la-mobilite-recule-a-la-menopause","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/pour-les-femmes-atteintes-de-sclerose-en-plaques-la-mobilite-recule-a-la-menopause\/","title":{"rendered":"Pour les femmes atteintes de scl\u00e9rose en plaques, la mobilit\u00e9 recule \u00e0 la m\u00e9nopause"},"content":{"rendered":"
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Une nouvelle \u00e9tude men\u00e9e par l’UC San Francisco a r\u00e9v\u00e9l\u00e9 que la m\u00e9nopause acc\u00e9l\u00e8re la progression de la scl\u00e9rose en plaques (SEP).<\/p>\n

La recherche est publi\u00e9e dans la revue Neurologie<\/i>.<\/p>\n

Apr\u00e8s la m\u00e9nopause, la marche des patientes ralentissait. Des changements plus subtils ont \u00e9galement \u00e9t\u00e9 observ\u00e9s au niveau de la motricit\u00e9 fine et des capacit\u00e9s cognitives.<\/p>\n

L’\u00e9tude soul\u00e8ve de nouvelles questions quant \u00e0 savoir si l’hormonoth\u00e9rapie peut aider les 30 \u00e0 40 % de patients atteints de SEP en p\u00e9rim\u00e9nopause ou en postm\u00e9nopause.<\/p>\n

Les femmes repr\u00e9sentent 75 % des patients atteints de SEP et les hormones jouent un r\u00f4le important dans l’\u00e9volution de la maladie.<\/p>\n

\u00ab\u00a0Nous savons que les changements hormonaux au cours de la pubert\u00e9 peuvent d\u00e9clencher des maladies auto-immunes comme la SEP\u00a0\u00bb, a d\u00e9clar\u00e9 Riley Bove, MD, professeur agr\u00e9g\u00e9 de neurologie \u00e0 l’UCSF. Bove est l’auteur correspondant de l’\u00e9tude. \u00ab\u00a0Nous constatons un taux de rechute plus faible au cours du troisi\u00e8me trimestre de la grossesse, suivi d’un rebond post-partum.\u00a0\u00bb<\/p>\n

L’\u00e9tude a suivi 184 femmes avant et apr\u00e8s la m\u00e9nopause. Il s’appuie sur les donn\u00e9es de deux \u00e9tudes de l’UCSF, EPIC et ORIGINS, qui cherchent \u00e0 d\u00e9couvrir les causes de la SEP et la mani\u00e8re dont elle se d\u00e9veloppe. Les participants ont \u00e9t\u00e9 \u00e9valu\u00e9s chaque ann\u00e9e pendant 13 ans en moyenne.<\/p>\n

D’autres recherches ont abouti \u00e0 des conclusions contradictoires sur le r\u00f4le de la m\u00e9nopause dans la progression de la SEP. Certaines \u00e9tudes ont utilis\u00e9 un outil appel\u00e9 EDSS (Expansed Disability Status Scale) qui se concentre principalement sur l\u2019\u00e9valuation de la marche.<\/p>\n

\u00ab\u00a0L’EDSS pr\u00e9sente un certain nombre de limites et peut \u00e9galement mesurer des changements qui ne sont pas li\u00e9s \u00e0 la SEP, tels que l’\u00e2ge avanc\u00e9 et la prise de m\u00e9dicaments multiples, qui peuvent tous deux affecter la mobilit\u00e9\u00a0\u00bb, a d\u00e9clar\u00e9 Hannah Silverman, \u00e9tudiante en m\u00e9decine \u00e0 l’UCSF, qui est la premi\u00e8re auteur de l’\u00e9tude.<\/p>\n

Diminution de la vitesse de marche, de la dext\u00e9rit\u00e9 et des capacit\u00e9s cognitives<\/h2>\n

Dans la pr\u00e9sente \u00e9tude, les chercheurs ont utilis\u00e9 le MS Functional Composite (MSFC), qui capture la vitesse de marche ainsi que d\u2019autres t\u00e2ches. Ils ont constat\u00e9 qu\u2019apr\u00e8s la m\u00e9nopause, il fallait plus de temps aux participantes pour effectuer une marche de 25 pieds apr\u00e8s avoir pris en compte l\u2019\u00e2ge, le poids et la consommation de tabac. Ils ont \u00e9galement constat\u00e9 des d\u00e9clins plus subtils de la dext\u00e9rit\u00e9 et de la cognition.<\/p>\n

Les chercheurs ont d\u00e9couvert qu\u2019un biomarqueur dans le sang appel\u00e9 cha\u00eene l\u00e9g\u00e8re des neurofilaments (NfL) augmentait apr\u00e8s la m\u00e9nopause. Cela indique une d\u00e9g\u00e9n\u00e9rescence accrue des cellules nerveuses \u2013 une caract\u00e9ristique de l\u2019\u00e9volution de la SEP \u2013 et valide les r\u00e9sultats du MSFC.<\/p>\n

Seulement 31 des 184 participants (17 %) ont suivi une \u0153strog\u00e9noth\u00e9rapie, ce qui n’est pas suffisant pour que les chercheurs puissent tirer des conclusions sur ses bienfaits. La recherche chez les animaux sugg\u00e8re que les hormones sexuelles ont des effets neuroprotecteurs, et une petite \u00e9tude a test\u00e9 les effets protecteurs de la testost\u00e9rone chez les hommes.<\/p>\n

\u00ab\u00a0L’\u00e9tude montre que la m\u00e9nopause repr\u00e9sente un facteur unique dans la progression de la SEP, m\u00eame si l’on prend en compte les effets du vieillissement\u00a0\u00bb, a d\u00e9clar\u00e9 Bove, qui est \u00e9galement membre de l’Institut Weill pour les neurosciences. \u00ab\u00a0Mais nous aurions besoin de grands essais randomis\u00e9s comparant le traitement hormonal \u00e0 un placebo avant de pouvoir conna\u00eetre les v\u00e9ritables effets de l’hormonoth\u00e9rapie dans une maladie aussi complexe que la SEP.\u00a0\u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Une nouvelle \u00e9tude men\u00e9e par l’UC San Francisco a r\u00e9v\u00e9l\u00e9 que la m\u00e9nopause acc\u00e9l\u00e8re la<\/p>\n","protected":false},"author":1,"featured_media":3399,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[101,297,49,3426,3424,770,8,3425,769],"class_list":["post-3398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-atteintes","tag-femmes","tag-les","tag-menopause","tag-mobilite","tag-plaques","tag-pour","tag-recule","tag-sclerose","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nPour les femmes atteintes de scl\u00e9rose en plaques, la mobilit\u00e9 recule \u00e0 la m\u00e9nopause - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/pour-les-femmes-atteintes-de-sclerose-en-plaques-la-mobilite-recule-a-la-menopause\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pour les femmes atteintes de scl\u00e9rose en plaques, la mobilit\u00e9 recule \u00e0 la m\u00e9nopause - 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