{"id":3286,"date":"2025-01-06T06:15:50","date_gmt":"2025-01-06T05:15:50","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/le-virus-de-lherpes-pourrait-etre-a-lorigine-de-la-pathologie-dalzheimer-suggere-une-etude\/"},"modified":"2025-01-06T06:16:08","modified_gmt":"2025-01-06T05:16:08","slug":"le-virus-de-lherpes-pourrait-etre-a-lorigine-de-la-pathologie-dalzheimer-suggere-une-etude","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/le-virus-de-lherpes-pourrait-etre-a-lorigine-de-la-pathologie-dalzheimer-suggere-une-etude\/","title":{"rendered":"Le virus de l’herp\u00e8s pourrait \u00eatre \u00e0 l’origine de la pathologie d’Alzheimer, sugg\u00e8re une \u00e9tude"},"content":{"rendered":"
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Des chercheurs de l’Universit\u00e9 de Pittsburgh ont d\u00e9couvert un lien surprenant entre la maladie d’Alzheimer et le virus de l’herp\u00e8s simplex-1 (HSV-1), sugg\u00e9rant que les infections virales pourraient jouer un r\u00f4le dans la maladie. Les r\u00e9sultats de l’\u00e9tude sont publi\u00e9s aujourd’hui dans Rapports de cellules<\/i>.<\/p>\n

L’\u00e9tude a \u00e9galement r\u00e9v\u00e9l\u00e9 comment la prot\u00e9ine tau, souvent consid\u00e9r\u00e9e comme nocive dans la maladie d’Alzheimer, pourrait initialement prot\u00e9ger le cerveau du virus, mais contribuer ensuite aux l\u00e9sions c\u00e9r\u00e9brales. Ces d\u00e9couvertes pourraient conduire \u00e0 de nouveaux traitements ciblant les infections et la r\u00e9ponse immunitaire du cerveau.<\/p>\n

\u00ab\u00a0Notre \u00e9tude remet en question la vision conventionnelle de la prot\u00e9ine Tau comme \u00e9tant uniquement nocive, montrant qu’elle peut initialement agir dans le cadre de la d\u00e9fense immunitaire du cerveau\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur principal Or Shemesh, Ph.D., professeur adjoint au d\u00e9partement d’ophtalmologie de Pitt. \u00ab\u00a0Ces r\u00e9sultats mettent l’accent sur l’interaction complexe entre les infections, les r\u00e9ponses immunitaires et la neurod\u00e9g\u00e9n\u00e9rescence, offrant ainsi une nouvelle perspective et de nouvelles cibles potentielles pour le d\u00e9veloppement th\u00e9rapeutique.\u00a0\u00bb<\/p>\n

Les scientifiques ont identifi\u00e9 des formes de prot\u00e9ines li\u00e9es au HSV-1 dans des \u00e9chantillons de cerveau d’Alzheimer, avec de plus grandes quantit\u00e9s de prot\u00e9ines virales co-localis\u00e9es avec des enchev\u00eatrements de tau phosphoryl\u00e9 – l’une des caract\u00e9ristiques de la pathologie de la maladie d’Alzheimer – dans les r\u00e9gions du cerveau particuli\u00e8rement vuln\u00e9rables \u00e0 la maladie d’Alzheimer \u00e0 diff\u00e9rents stades de la maladie. .<\/p>\n

D’autres \u00e9tudes sur des mod\u00e8les miniatures de cerveaux humains dans une bo\u00eete de P\u00e9tri ont sugg\u00e9r\u00e9 que l’infection par le HSV-1 pourrait moduler les niveaux de prot\u00e9ine tau c\u00e9r\u00e9brale et r\u00e9guler sa fonction, un m\u00e9canisme de protection qui semble diminuer la mort des neurones humains apr\u00e8s infection.<\/p>\n

Bien que les m\u00e9canismes pr\u00e9cis par lesquels le HSV-1 influence la prot\u00e9ine tau et contribuent \u00e0 la maladie d’Alzheimer soient encore inconnus, Shemesh et ses coll\u00e8gues pr\u00e9voient d’explorer ces questions dans de futures recherches. Ils visent \u00e0 tester des strat\u00e9gies th\u00e9rapeutiques potentielles ciblant les prot\u00e9ines virales ou \u00e0 affiner la r\u00e9ponse immunitaire du cerveau et \u00e0 d\u00e9terminer si des m\u00e9canismes similaires sont impliqu\u00e9s dans d’autres maladies neurod\u00e9g\u00e9n\u00e9ratives, telles que la maladie de Parkinson et la SLA.<\/p>\n

Les autres auteurs de l’\u00e9tude sont Vanesa Hyde, Chaoming Zhou, MD, Juan Fernandez, Krishnashis Chatterjee, Ph.D., Pururav Ramakrishna, Amanda Lin, Gregory Fisher, Ph.D., Orhan Tun\u00e7 \u00c7eliker, Jill Caldwell et Leonardo D’. Aiuto, Ph.D., tous de Pitt\u00a0; Omer Bender, Ph.D., et Daniel Bar, Ph.D., tous deux de l’Universit\u00e9 de Tel Aviv ; et Peter Joseph Sauer et Jose Lugo-Martinez, Ph.D., tous deux de l’Universit\u00e9 Carnegie Mellon.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de l’Universit\u00e9 de Pittsburgh ont d\u00e9couvert un lien surprenant entre la maladie d’Alzheimer<\/p>\n","protected":false},"author":1,"featured_media":3287,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[676,204,48,1625,1257,3373,203,1118,47,630],"class_list":["post-3286","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-dalzheimer","tag-etre","tag-etude","tag-lherpes","tag-lorigine","tag-pathologie","tag-pourrait","tag-suggere","tag-une","tag-virus","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLe virus de l'herp\u00e8s pourrait \u00eatre \u00e0 l'origine de la pathologie d'Alzheimer, sugg\u00e8re une \u00e9tude - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/le-virus-de-lherpes-pourrait-etre-a-lorigine-de-la-pathologie-dalzheimer-suggere-une-etude\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le virus de l'herp\u00e8s pourrait \u00eatre \u00e0 l'origine de la pathologie d'Alzheimer, sugg\u00e8re une \u00e9tude - 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