{"id":3207,"date":"2025-01-02T22:59:51","date_gmt":"2025-01-02T21:59:51","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/un-medicament-contre-le-tdah-semble-prometteur-pour-traiter-la-dependance-a-la-methamphetamine\/"},"modified":"2025-01-02T23:00:04","modified_gmt":"2025-01-02T22:00:04","slug":"un-medicament-contre-le-tdah-semble-prometteur-pour-traiter-la-dependance-a-la-methamphetamine","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/un-medicament-contre-le-tdah-semble-prometteur-pour-traiter-la-dependance-a-la-methamphetamine\/","title":{"rendered":"Un m\u00e9dicament contre le TDAH semble prometteur pour traiter la d\u00e9pendance \u00e0 la m\u00e9thamph\u00e9tamine"},"content":{"rendered":"
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Un m\u00e9dicament sur ordonnance utilis\u00e9 pour traiter le trouble d\u00e9ficitaire de l’attention avec hyperactivit\u00e9 (TDAH) pourrait \u00eatre r\u00e9utilis\u00e9 comme premi\u00e8re pharmacoth\u00e9rapie pour les personnes d\u00e9pendantes \u00e0 la m\u00e9thamph\u00e9tamine, selon une \u00e9tude publi\u00e9e dans D\u00e9pendance<\/i>.<\/p>\n

Les r\u00e9sultats de l’essai historique \u00ab\u00a0LiMA\u00a0\u00bb montrent que le psychostimulant lisdexamf\u00e9tamine peut r\u00e9duire consid\u00e9rablement le besoin de consommer de la m\u00e9thamph\u00e9tamine chez les personnes d\u00e9pendantes de cette drogue illicite.<\/p>\n

L’auteur principal et sp\u00e9cialiste de la m\u00e9decine des addictions, le professeur Nadine Ezard, directrice du Centre national de recherche clinique sur les drogues \u00e9mergentes (NCCRED), a d\u00e9clar\u00e9 que les r\u00e9sultats \u00e9taient prometteurs.<\/p>\n

\u00ab\u00a0Il n’existe actuellement aucune pharmacoth\u00e9rapie approuv\u00e9e pour traiter la d\u00e9pendance \u00e0 la m\u00e9thamph\u00e9tamine\u00a0\u00bb, a d\u00e9clar\u00e9 le professeur Ezard.<\/p>\n

\u00ab\u00a0Bien que des recherches plus approfondies soient n\u00e9cessaires, des cliniciens exp\u00e9riment\u00e9s pourraient envisager une prescription hors AMM de lisdexamf\u00e9tamine, avec une surveillance \u00e9troite des risques et des avantages, conform\u00e9ment aux lignes directrices actuelles sur les psychostimulants, pour les personnes souffrant de troubles li\u00e9s \u00e0 l’usage de m\u00e9thamph\u00e9tamine.\u00a0\u00bb<\/p>\n

Dans le cadre de l’essai, l’\u00e9quipe du professeur Ezard du NCCRED, bas\u00e9e au Centre national de recherche sur les drogues et l’alcool (NDARC), UNSW Sydney, a recrut\u00e9 164 adultes d\u00e9pendants \u00e0 la m\u00e9thamph\u00e9tamine et qui avaient d\u00e9clar\u00e9 avoir consomm\u00e9 de la drogue lors d’au moins 14 des pr\u00e9c\u00e9dentes. 28 jours.<\/p>\n

Les participants ont \u00e9t\u00e9 assign\u00e9s au hasard \u00e0 un r\u00e9gime de 15 semaines avec de la lisdexamf\u00e9tamine (une semaine d’induction, 12 semaines d’entretien \u00e0 250 mg\/jour et une r\u00e9duction de deux semaines) ou un placebo, et suivis pendant quatre semaines apr\u00e8s le traitement.<\/p>\n

Dans l\u2019ensemble, ceux qui ont re\u00e7u de la lisdexamf\u00e9tamine ont consomm\u00e9 en moyenne 8,8 jours de moins de m\u00e9thamph\u00e9tamine au cours de la phase d\u2019entretien de 12 semaines que ceux du groupe placebo.<\/p>\n

Ceux qui ont re\u00e7u le m\u00e9dicament contre le TDAH pr\u00e9sentaient \u00e9galement des taux d’efficacit\u00e9 du traitement (2,9 fois plus \u00e9lev\u00e9s) et de satisfaction du traitement (3,8 fois plus \u00e9lev\u00e9s) que les participants ayant re\u00e7u un placebo.<\/p>\n

Les effets ont \u00e9t\u00e9 plus fortement observ\u00e9s au cours des premi\u00e8res semaines de l\u2019essai.<\/p>\n

\u00ab\u00a0Bien que l’effet b\u00e9n\u00e9fique ait diminu\u00e9 vers la fin de la p\u00e9riode de traitement, l’exploration des caract\u00e9ristiques des \u00ab\u00a0r\u00e9pondeurs pr\u00e9coces\u00a0\u00bb dans notre \u00e9tude sera utile pour comprendre qui pourrait b\u00e9n\u00e9ficier le plus des th\u00e9rapies agonistes\u00a0\u00bb, a d\u00e9clar\u00e9 le professeur Ezard.<\/p>\n

Elle a ajout\u00e9 qu’il n’y avait aucun probl\u00e8me de s\u00e9curit\u00e9 inattendu avec la lisdexamf\u00e9tamine \u00e0 forte dose, la plupart des \u00e9v\u00e9nements ind\u00e9sirables \u00e9tant jug\u00e9s de gravit\u00e9 l\u00e9g\u00e8re ou mod\u00e9r\u00e9e.<\/p>\n

Les participants \u00e0 l\u2019essai ont \u00e9t\u00e9 recrut\u00e9s dans six cliniques ambulatoires sp\u00e9cialis\u00e9es \u00e0 Sydney, Newcastle, Melbourne et Ad\u00e9la\u00efde entre mai 2018 et d\u00e9cembre 2021, avec une suspension de recrutement de neuf mois en 2020 en raison de la pand\u00e9mie de COVID-19.<\/p>\n

Une limite importante de l\u2019\u00e9tude \u00e9tait le taux d\u2019attrition \u00e9lev\u00e9 de 39 %. Bien que cela concorde avec d\u2019autres \u00e9tudes ambulatoires sur les troubles li\u00e9s \u00e0 l\u2019usage de m\u00e9thamph\u00e9tamine, cela a eu un impact sur la force statistique des r\u00e9sultats.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par le Centre national de recherche sur les drogues et l’alcool (NDARC)<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Un m\u00e9dicament sur ordonnance utilis\u00e9 pour traiter le trouble d\u00e9ficitaire de l’attention avec hyperactivit\u00e9 (TDAH)<\/p>\n","protected":false},"author":1,"featured_media":3208,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[90,410,1046,1102,8,437,2509,903,1165],"class_list":["post-3207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-addictions","tag-contre","tag-dependance","tag-medicament","tag-methamphetamine","tag-pour","tag-prometteur","tag-semble","tag-tdah","tag-traiter","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUn m\u00e9dicament contre le TDAH semble prometteur pour traiter la d\u00e9pendance \u00e0 la m\u00e9thamph\u00e9tamine - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/un-medicament-contre-le-tdah-semble-prometteur-pour-traiter-la-dependance-a-la-methamphetamine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un m\u00e9dicament contre le TDAH semble prometteur pour traiter la d\u00e9pendance \u00e0 la m\u00e9thamph\u00e9tamine - 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