{"id":314,"date":"2024-09-12T22:44:10","date_gmt":"2024-09-12T20:44:10","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-methode-predit-laggravation-de-la-maladie-renale-chronique\/"},"modified":"2024-09-12T22:44:12","modified_gmt":"2024-09-12T20:44:12","slug":"une-nouvelle-methode-predit-laggravation-de-la-maladie-renale-chronique","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-methode-predit-laggravation-de-la-maladie-renale-chronique\/","title":{"rendered":"Une nouvelle m\u00e9thode pr\u00e9dit l’aggravation de la maladie r\u00e9nale chronique"},"content":{"rendered":"
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Des chercheurs de l\u2019Universit\u00e9 d\u2019Aarhus ont mis au point une nouvelle m\u00e9thode permettant de pr\u00e9dire quels patients souffrant d\u2019insuffisance r\u00e9nale chronique risquent de perdre leur fonction r\u00e9nale au fil du temps. La m\u00e9thode repose sur une analyse des \u00e9quilibres acido-basiques dans des \u00e9chantillons d\u2019urine, qui peut r\u00e9v\u00e9ler des signes pr\u00e9coces d\u2019accumulation d\u2019acide, une condition qui peut nuire \u00e0 la fonction r\u00e9nale.<\/p>\n

\u00ab Nous avons d\u00e9couvert que l’\u00e9quilibre entre les diff\u00e9rents \u00e9l\u00e9ments acido-basiques dans les \u00e9chantillons d’urine de patients atteints d’insuffisance r\u00e9nale chronique diff\u00e8re consid\u00e9rablement de celui des individus sains. Cela nous a conduit \u00e0 d\u00e9velopper un mod\u00e8le de calcul o\u00f9 la relation entre plusieurs \u00e9l\u00e9ments acido-basiques de l’urine pourrait \u00eatre associ\u00e9e \u00e0 la fonction r\u00e9nale et \u00e0 la progression de la maladie au fil du temps \u00bb, explique Mads Vaarby S\u00f8rensen, Ph.D. et chercheur au d\u00e9partement de biom\u00e9decine de l’universit\u00e9 d’Aarhus.<\/p>\n

La recherche est publi\u00e9e dans le Journal de la Soci\u00e9t\u00e9 Am\u00e9ricaine de N\u00e9phrologie<\/i>.<\/p>\n

La nouvelle m\u00e9thode permet aux m\u00e9decins de d\u00e9tecter l’acidit\u00e9 plus t\u00f4t que ce que permettent les analyses sanguines actuelles. Selon S\u00f8rensen, les biomarqueurs existants ne peuvent mesurer l’acidit\u00e9 que lorsqu’elle est suffisamment importante pour affecter l’\u00e9quilibre acido-basique du sang.<\/p>\n

Le nouveau score acido-basique permet de d\u00e9tecter des d\u00e9s\u00e9quilibres urinaires beaucoup plus t\u00f4t dans le processus. Un autre avantage de la nouvelle m\u00e9thode est sa pr\u00e9cision.<\/p>\n

\u00ab Notre m\u00e9thode a \u00e9t\u00e9 test\u00e9e dans plusieurs cohortes ind\u00e9pendantes et s’est av\u00e9r\u00e9e tr\u00e8s pr\u00e9cise, m\u00eame lorsque nous analysons des \u00e9chantillons d’urine des m\u00eames patients sur une p\u00e9riode plus longue \u00bb, explique Peder Berg, MD et postdoctorant au D\u00e9partement de biom\u00e9decine de l’Universit\u00e9 d’Aarhus.<\/p>\n

Cette m\u00e9thode pourrait changer la mani\u00e8re dont les patients atteints d\u2019insuffisance r\u00e9nale chronique sont suivis et trait\u00e9s. Elle permet de distinguer les patients dont la fonction r\u00e9nale est stable de ceux qui la perdent rapidement.<\/p>\n

La maladie r\u00e9nale chronique touche plus de dix pour cent de la population adulte et repr\u00e9sente une demande importante en ressources de soins de sant\u00e9.<\/p>\n

\u00ab La nouvelle m\u00e9thode pourrait potentiellement r\u00e9duire le besoin de contr\u00f4les fr\u00e9quents pour les patients stables et lib\u00e9rer des ressources pour ceux dont la progression de la maladie est plus agressive \u00bb, explique Samuel Svendsen, r\u00e9sident en m\u00e9decine au d\u00e9partement de n\u00e9phrologie de l’h\u00f4pital universitaire d’Aarhus.<\/p>\n

Le groupe de recherche est d\u00e9j\u00e0 en dialogue avec plusieurs partenaires internationaux pour \u00e9tendre ses recherches dans ce domaine. \u00c0 court terme, les chercheurs esp\u00e8rent valider la m\u00e9thode sur 4 000 patients en collaboration avec de grands centres de recherche europ\u00e9ens et am\u00e9ricains. \u00c0 long terme, les chercheurs esp\u00e8rent que la nouvelle m\u00e9thode pourra aider \u00e0 individualiser le traitement des maladies r\u00e9nales.<\/p>\n

\u00ab Si nous pouvons pr\u00e9dire l\u2019accumulation d\u2019acide plus t\u00f4t, nous pouvons intervenir plus t\u00f4t avec un traitement de r\u00e9duction de l\u2019acide, ce qui pourrait potentiellement prolonger la p\u00e9riode pendant laquelle les patients peuvent \u00e9viter la dialyse \u00bb, explique Svendsen.<\/p>\n

Cette m\u00e9thode n\u2019est pas encore int\u00e9gr\u00e9e \u00e0 la pratique clinique, mais des chercheurs ont d\u00e9velopp\u00e9 un appareil capable de mesurer automatiquement les marqueurs pertinents dans l\u2019urine. L\u2019appareil est con\u00e7u pour s\u2019int\u00e9grer dans le flux de travail des services de n\u00e9phrologie et son fonctionnement est \u00e9conomique.<\/p>\n

\u00ab Si la m\u00e9thode s’av\u00e8re utile \u00e0 la fois pour les patients et pour le syst\u00e8me de sant\u00e9, elle pourrait devenir un outil important dans le traitement futur de la maladie r\u00e9nale chronique \u00bb, d\u00e9clare S\u00f8rensen.<\/p>\n

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Des chercheurs de l\u2019Universit\u00e9 d\u2019Aarhus ont mis au point une nouvelle m\u00e9thode permettant de pr\u00e9dire<\/p>\n","protected":false},"author":1,"featured_media":315,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[250,247,248,245,244,246,249,47],"class_list":["post-314","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-chronique","tag-laggravation","tag-maladie","tag-methode","tag-nouvelle","tag-predit","tag-renale","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne nouvelle m\u00e9thode pr\u00e9dit l'aggravation de la maladie r\u00e9nale chronique - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-nouvelle-methode-predit-laggravation-de-la-maladie-renale-chronique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une nouvelle m\u00e9thode pr\u00e9dit l'aggravation de la maladie r\u00e9nale chronique - 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