{"id":2512,"date":"2024-11-29T22:02:37","date_gmt":"2024-11-29T21:02:37","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/long-covid-accumulation-de-proteines-de-pointe-du-sras-cov-2-liee-a-des-effets-cerebraux-durables\/"},"modified":"2024-11-29T22:02:56","modified_gmt":"2024-11-29T21:02:56","slug":"long-covid-accumulation-de-proteines-de-pointe-du-sras-cov-2-liee-a-des-effets-cerebraux-durables","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/long-covid-accumulation-de-proteines-de-pointe-du-sras-cov-2-liee-a-des-effets-cerebraux-durables\/","title":{"rendered":"Long COVID\u00a0: accumulation de prot\u00e9ines de pointe du SRAS-CoV-2 li\u00e9e \u00e0 des effets c\u00e9r\u00e9braux durables"},"content":{"rendered":"
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Des chercheurs de Helmholtz Munich et de la Ludwig-Maximilians-Universit\u00e4t (LMU) ont identifi\u00e9 un m\u00e9canisme qui pourrait expliquer les sympt\u00f4mes neurologiques du long COVID.<\/p>\n

L’\u00e9tude montre que la prot\u00e9ine Spike du SRAS-CoV-2 reste dans les couches protectrices du cerveau, les m\u00e9ninges et la moelle osseuse du cr\u00e2ne jusqu’\u00e0 quatre ans apr\u00e8s l’infection. Cette pr\u00e9sence persistante de la prot\u00e9ine Spike pourrait d\u00e9clencher une inflammation chronique chez les personnes touch\u00e9es et augmenter le risque de maladies neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n

L’\u00e9quipe, dirig\u00e9e par le professeur Ali Ert\u00fcrk, directeur de l’Institut des biotechnologies intelligentes de Helmholtz Munich, a \u00e9galement d\u00e9couvert que les vaccins \u00e0 ARNm contre le COVID-19 r\u00e9duisent consid\u00e9rablement l’accumulation de la prot\u00e9ine de pointe dans le cerveau. Cependant, la persistance de la prot\u00e9ine Spike apr\u00e8s une infection dans le cr\u00e2ne et les m\u00e9ninges offre une cible pour de nouvelles strat\u00e9gies th\u00e9rapeutiques.<\/p>\n

La prot\u00e9ine Spike s\u2019accumule dans le cerveau<\/h2>\n

Une nouvelle technique d’imagerie bas\u00e9e sur l’IA d\u00e9velopp\u00e9e par l’\u00e9quipe du professeur Ert\u00fcrk fournit de nouvelles informations sur la fa\u00e7on dont la prot\u00e9ine de pointe du SRAS-CoV-2 affecte le cerveau. La m\u00e9thode rend les \u00e9chantillons d\u2019organes et de tissus transparents, permettant la visualisation tridimensionnelle des structures cellulaires, des m\u00e9tabolites et, dans ce cas, des prot\u00e9ines virales. Gr\u00e2ce \u00e0 cette technologie, les chercheurs ont d\u00e9couvert des distributions auparavant ind\u00e9tectables de prot\u00e9ines de pointe dans des \u00e9chantillons de tissus provenant de patients et de souris atteints du COVID-19.<\/p>\n

L’\u00e9tude, publi\u00e9e dans la revue H\u00f4te cellulaire et microbe<\/i>a r\u00e9v\u00e9l\u00e9 des concentrations significativement \u00e9lev\u00e9es de prot\u00e9ine de pointe dans la moelle osseuse et les m\u00e9ninges du cr\u00e2ne, m\u00eame des ann\u00e9es apr\u00e8s l’infection. La prot\u00e9ine Spike se lie aux r\u00e9cepteurs dits ACE2, particuli\u00e8rement abondants dans ces r\u00e9gions.<\/p>\n

\u00ab\u00a0Cela pourrait rendre ces tissus particuli\u00e8rement vuln\u00e9rables \u00e0 l’accumulation \u00e0 long terme de prot\u00e9ines de pointe\u00a0\u00bb, explique le Dr Zhouyi Rong, premier auteur de l’\u00e9tude.<\/p>\n

Ert\u00fcrk ajoute : \u00ab Nos donn\u00e9es sugg\u00e8rent \u00e9galement que la prot\u00e9ine de pointe persistante aux fronti\u00e8res du cerveau peut contribuer aux effets neurologiques \u00e0 long terme du COVID-19 et du long COVID. Cela inclut un vieillissement acc\u00e9l\u00e9r\u00e9 du cerveau, conduisant potentiellement \u00e0 une perte de cinq \u00e0 dix ans de vie. fonction c\u00e9r\u00e9brale saine chez les personnes affect\u00e9es.<\/p>\n

Les vaccins r\u00e9duisent l\u2019accumulation de prot\u00e9ines de pointe et l\u2019inflammation c\u00e9r\u00e9brale<\/h2>\n

L\u2019\u00e9quipe d\u2019Ert\u00fcrk a d\u00e9couvert que le vaccin BioNTech\/Pfizer \u00e0 ARNm COVID-19 r\u00e9duit consid\u00e9rablement l\u2019accumulation de prot\u00e9ines de pointe dans le cerveau. D\u2019autres vaccins ou types de vaccins \u00e0 ARNm, tels que les vaccins \u00e0 base de vecteurs ou de prot\u00e9ines, n\u2019ont pas \u00e9t\u00e9 \u00e9tudi\u00e9s.<\/p>\n

Les souris vaccin\u00e9es avec le vaccin \u00e0 ARNm ont montr\u00e9 des niveaux inf\u00e9rieurs de prot\u00e9ine de pointe dans le tissu c\u00e9r\u00e9bral et la moelle osseuse du cr\u00e2ne par rapport aux souris non vaccin\u00e9es. Cependant, la r\u00e9duction n\u2019\u00e9tait que d\u2019environ 50 %, laissant des prot\u00e9ines de pointe r\u00e9siduelles qui continuent de pr\u00e9senter un risque toxique pour le cerveau.<\/p>\n

\u00ab\u00a0Cette r\u00e9duction est une \u00e9tape importante\u00a0\u00bb, d\u00e9clare le professeur Ert\u00fcrk. \u00ab Nos r\u00e9sultats, bien que d\u00e9riv\u00e9s de mod\u00e8les murins et seulement partiellement transf\u00e9rables aux humains, soulignent la n\u00e9cessit\u00e9 de th\u00e9rapies et d’interventions suppl\u00e9mentaires pour r\u00e9pondre pleinement aux fardeaux \u00e0 long terme caus\u00e9s par les infections par le SRAS-CoV-2. \u00bb<\/p>\n

De plus, des \u00e9tudes suppl\u00e9mentaires sont n\u00e9cessaires pour \u00e9valuer la pertinence de ces r\u00e9sultats pour les patients atteints d\u2019une longue COVID.<\/p>\n

COVID long : Un d\u00e9fi soci\u00e9tal et m\u00e9dical<\/h2>\n

\u00c0 l\u2019\u00e9chelle mondiale, 50 \u00e0 60 pour cent de la population a \u00e9t\u00e9 infect\u00e9e par le COVID-19, et cinq \u00e0 dix pour cent souffrent d\u2019un long COVID. Cela repr\u00e9sente environ 400 millions d\u2019individus susceptibles de transporter des quantit\u00e9s importantes de prot\u00e9ines de pointe.<\/p>\n

\u00ab\u00a0Il ne s’agit pas seulement d’un probl\u00e8me de sant\u00e9 individuel : c’est un d\u00e9fi soci\u00e9tal\u00a0\u00bb, d\u00e9clare le professeur Ert\u00fcrk. \u00ab\u00a0Notre \u00e9tude montre que les vaccins \u00e0 ARNm r\u00e9duisent consid\u00e9rablement le risque de cons\u00e9quences neurologiques \u00e0 long terme et offrent une protection cruciale. Cependant, des infections peuvent toujours survenir apr\u00e8s la vaccination, entra\u00eenant la persistance de prot\u00e9ines de pointe dans le corps.<\/p>\n

\u00ab\u00a0Ceux-ci peuvent entra\u00eener une inflammation chronique du cerveau et un risque accru d’accidents vasculaires c\u00e9r\u00e9braux et d’autres l\u00e9sions c\u00e9r\u00e9brales, ce qui pourrait avoir des implications substantielles pour la sant\u00e9 publique mondiale et les syst\u00e8mes de soins de sant\u00e9 du monde entier.\u00a0\u00bb<\/p>\n

Avanc\u00e9es en mati\u00e8re de diagnostic et de traitement<\/h2>\n

\u00ab\u00a0Nos r\u00e9sultats ouvrent de nouvelles possibilit\u00e9s pour diagnostiquer et traiter les effets neurologiques \u00e0 long terme du COVID-19\u00a0\u00bb, explique Ert\u00fcrk.<\/p>\n

Contrairement au tissu c\u00e9r\u00e9bral, la moelle osseuse et les m\u00e9ninges du cr\u00e2ne, zones sujettes \u00e0 l’accumulation de prot\u00e9ines, sont plus accessibles aux examens m\u00e9dicaux. Combin\u00e9 avec des panels de prot\u00e9ines \u2013 des tests con\u00e7us pour d\u00e9tecter des prot\u00e9ines sp\u00e9cifiques dans des \u00e9chantillons de tissus \u2013 cela pourrait permettre l\u2019identification de prot\u00e9ines de pointe ou de marqueurs inflammatoires dans le plasma sanguin ou le liquide c\u00e9phalo-rachidien.<\/p>\n

\u00ab\u00a0De tels marqueurs sont essentiels au diagnostic pr\u00e9coce des complications neurologiques li\u00e9es au COVID-19\u00a0\u00bb, explique Ert\u00fcrk. \u00ab De plus, la caract\u00e9risation de ces prot\u00e9ines peut soutenir le d\u00e9veloppement de th\u00e9rapies cibl\u00e9es et de biomarqueurs pour mieux traiter ou m\u00eame pr\u00e9venir les d\u00e9ficiences neurologiques caus\u00e9es par le COVID-19. \u00bb<\/p>\n

Soulignant l’impact plus large de l’\u00e9tude, le professeur Ulrike Protzer, virologue de Helmholtz Munich et de l’Universit\u00e9 technique de Munich, ajoute : \u00ab Compte tenu de l’impact mondial actuel du COVID-19 et de l’attention croissante port\u00e9e aux effets \u00e0 long terme, cette \u00e9tude, qui met en lumi\u00e8re les voies d’invasion du cerveau et l’implication inattendue de l’h\u00f4te \u00e0 long terme, arrivent \u00e0 point nomm\u00e9. Ces informations critiques sont non seulement scientifiquement significatives, mais pr\u00e9sentent \u00e9galement un grand int\u00e9r\u00eat pour la soci\u00e9t\u00e9.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de Helmholtz Munich et de la Ludwig-Maximilians-Universit\u00e4t (LMU) ont identifi\u00e9 un m\u00e9canisme qui<\/p>\n","protected":false},"author":1,"featured_media":2513,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2806,2710,618,16,2807,1697,664,619,946,1204,1913],"class_list":["post-2512","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-accumulation","tag-cerebraux","tag-covid","tag-des","tag-durables","tag-effets","tag-liee","tag-long","tag-pointe","tag-proteines","tag-srascov2","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLong COVID\u00a0: accumulation de prot\u00e9ines de pointe du SRAS-CoV-2 li\u00e9e \u00e0 des effets c\u00e9r\u00e9braux durables - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/long-covid-accumulation-de-proteines-de-pointe-du-sras-cov-2-liee-a-des-effets-cerebraux-durables\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Long COVID\u00a0: accumulation de prot\u00e9ines de pointe du SRAS-CoV-2 li\u00e9e \u00e0 des effets c\u00e9r\u00e9braux durables - 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