{"id":2375,"date":"2024-11-24T13:57:23","date_gmt":"2024-11-24T12:57:23","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/des-etudes-de-surveillance-genomique-revelent-la-circulation-denterobacteries-multiresistantes-en-europe\/"},"modified":"2024-11-24T13:57:24","modified_gmt":"2024-11-24T12:57:24","slug":"des-etudes-de-surveillance-genomique-revelent-la-circulation-denterobacteries-multiresistantes-en-europe","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/des-etudes-de-surveillance-genomique-revelent-la-circulation-denterobacteries-multiresistantes-en-europe\/","title":{"rendered":"Des \u00e9tudes de surveillance g\u00e9nomique r\u00e9v\u00e8lent la circulation d\u2019ent\u00e9robact\u00e9ries multir\u00e9sistantes en Europe"},"content":{"rendered":"
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Les patients cherchant un traitement \u00e0 l\u2019h\u00f4pital ou dans d\u2019autres \u00e9tablissements de soins de sant\u00e9 peuvent \u00eatre particuli\u00e8rement vuln\u00e9rables aux infections qu\u2019ils contractent pendant leur s\u00e9jour, surtout si les infections sont difficiles \u00e0 traiter car elles r\u00e9sistent aux m\u00e9dicaments couramment utilis\u00e9s. Par exemple, les ent\u00e9robact\u00e9ries r\u00e9sistantes aux carbap\u00e9n\u00e8mes (CRE) sont connues pour affecter particuli\u00e8rement les patients hospitalis\u00e9s.<\/p>\n

Deux \u00e9tudes publi\u00e9es dans Eurosurveillance<\/i> marquant la Semaine mondiale de sensibilisation \u00e0 la RAM du 18 au 22 novembre 2024, a analys\u00e9 de nouvelles donn\u00e9es sur la propagation de ces CRE, \u00e0 savoir Escherichia coli de type s\u00e9quence (ST) 131 produisant diverses carbap\u00e9n\u00e9mases et la m\u00e9tallo-b\u00eata-lactamase-1 de New Delhi (NDM-1) – produisant Providencia stuartii pour \u00e9clairer d\u2019\u00e9ventuelles actions de sant\u00e9 publique.<\/p>\n

La lign\u00e9e d’Escherichia coli pr\u00e9sentant un profil de r\u00e9sistance \u00e9mergent se propage dans la communaut\u00e9<\/h2>\n

Dans une communication rapide, Kohlenberg et ses collaborateurs ont \u00e9valu\u00e9 les donn\u00e9es g\u00e9nomiques et \u00e9pid\u00e9miologiques de 17 pays de l’UE\/EEE et ont observ\u00e9 l’\u00e9mergence d’Escherichia coli qui produit des carbap\u00e9n\u00e9mases.<\/p>\n

Dans le monde entier, E. coli est l’agent pathog\u00e8ne associ\u00e9 \u00e0 la plupart des d\u00e9c\u00e8s attribuables \u00e0 la r\u00e9sistance aux antimicrobiens et le type sp\u00e9cifique d’E. coli que les auteurs ont \u00e9tudi\u00e9 dans leur \u00e9tude (ST 131) a \u00e9t\u00e9 d\u00e9tect\u00e9 dans le monde entier et est fr\u00e9quemment associ\u00e9 \u00e0 une multir\u00e9sistance aux m\u00e9dicaments.<\/p>\n

Kohlenberg et ses collaborateurs ont analys\u00e9 le s\u00e9quen\u00e7age et les donn\u00e9es \u00e9pid\u00e9miologiques de pr\u00e8s de 600 isolats d’E. coli ST131 fournis par des laboratoires nationaux de r\u00e9f\u00e9rence d’Autriche, de Belgique, de Tch\u00e9quie, du Danemark, de Finlande, de France, de Hongrie, d’Irlande, d’Allemagne, de Lettonie, de Lituanie, du Luxembourg, des Pays-Bas, Norv\u00e8ge, Portugal, Slov\u00e9nie et Su\u00e8de.<\/p>\n

La d\u00e9tection des isolats d’E. coli ST131 produisant des carbap\u00e9n\u00e9mases a augment\u00e9 avec le temps. Un groupe d’isolats s’est distingu\u00e9 par son association potentielle avec des infections des voies urinaires dans la communaut\u00e9, d\u00e9duite de l’\u00e2ge m\u00e9dian relativement bas des patients (57 ans), d’une proportion \u00e9lev\u00e9e de patientes de sexe f\u00e9minin et de la d\u00e9tection fr\u00e9quente d’isolats \u00e0 partir d’\u00e9chantillons d’urine. Les auteurs notent que \u00ab les infections des voies urinaires contract\u00e9es dans la communaut\u00e9 pourraient ne repr\u00e9senter que la pointe de l’iceberg en termes de colonisation des patients dans la communaut\u00e9 \u00bb.<\/p>\n

Bien que Kohlenberg et son \u00e9quipe reconnaissent qu’ils n’ont pas analys\u00e9 une population al\u00e9atoire d’E. coli ST131 mais des isolats pr\u00e9s\u00e9lectionn\u00e9s provenant des laboratoires de r\u00e9f\u00e9rence, ce qui a probablement abouti \u00e0 une collecte d’isolats pr\u00e9sentant une probabilit\u00e9 plus \u00e9lev\u00e9e de co-portage d’autres marqueurs de r\u00e9sistance, ils soutiennent que le Les r\u00e9sultats de leur \u00e9tude dans 17 pays de l’UE\/EEE \u00ab envoient un nouvel avertissement concernant l’aggravation de la situation \u00e9pid\u00e9miologique des ent\u00e9robact\u00e9ries productrices de carbap\u00e9n\u00e9mases dans l’UE\/EEE. Les g\u00e8nes de carbap\u00e9n\u00e9mase signifieraient que les carbap\u00e9n\u00e8mes ne pourraient plus \u00eatre constamment efficaces pour le traitement empirique des infections graves \u00e0 E. coli. \u00bb<\/p>\n

Transmission soutenue de Providencia stuartii r\u00e9sistante aux carbap\u00e9n\u00e8mes dans le syst\u00e8me de sant\u00e9<\/h2>\n

Un type de CRE qui a \u00e9t\u00e9 tr\u00e8s rare en Europe jusqu’\u00e0 pr\u00e9sent \u2013 \u200b\u200bla Providencia stuartii productrice de m\u00e9tallo-b\u00eata-lactamase-1 (NDM-1) de New Delhi \u2013 a maintenant \u00e9t\u00e9 d\u00e9tect\u00e9 dans plusieurs h\u00f4pitaux de Roumanie.<\/p>\n

Dans leur enqu\u00eate g\u00e9nomique, Linkevicius et son \u00e9quipe ont examin\u00e9 comment P. stuartii, producteur de NDM-1, se propage dans les h\u00f4pitaux dans le but de g\u00e9n\u00e9rer des informations opportunes pour contr\u00f4ler toute transmission ult\u00e9rieure.<\/p>\n

Dans leur \u00e9tude, les auteurs ont analys\u00e9 74 \u00e9chantillons de P. stuartii re\u00e7us de six h\u00f4pitaux de Roumanie. La plupart (n = 72\/74) des isolats r\u00e9cup\u00e9r\u00e9s \u00e9taient li\u00e9s \u00e0 une infection signal\u00e9e chez les patients, telle qu’une infection du sang des voies respiratoires inf\u00e9rieures ou des voies urinaires. Les auteurs ont class\u00e9 la majorit\u00e9 des infections comme associ\u00e9es aux soins de sant\u00e9, c’est-\u00e0-dire que les patients les ont contract\u00e9es dans un h\u00f4pital ou dans un autre \u00e9tablissement de soins de sant\u00e9.<\/p>\n

Compte tenu de leur r\u00e9sistance \u00e0 plusieurs classes d\u2019antibiotiques comme les p\u00e9nicillines, les c\u00e9phalosporines et les carbap\u00e9n\u00e8mes, 90 % des isolats test\u00e9s dans cette \u00e9tude ont \u00e9t\u00e9 class\u00e9s comme multir\u00e9sistants. Dans leur enqu\u00eate, Linkevicius et son \u00e9quipe ont identifi\u00e9 quatre groupes multi-h\u00f4pitaux de ces isolats r\u00e9sistants d\u00e9tect\u00e9s sur une ann\u00e9e. Cela indique une transmission soutenue au sein du syst\u00e8me de sant\u00e9 roumain sur une p\u00e9riode plus longue.<\/p>\n

En pla\u00e7ant les r\u00e9sultats de leur \u00e9tude dans un contexte international en les comparant avec les donn\u00e9es d’autres pays, les auteurs pourraient \u00e9galement relier la lign\u00e9e sp\u00e9cifique de P. stuartii d\u00e9tect\u00e9e en Roumanie \u00e0 des isolats trouv\u00e9s dans d’autres pays, \u00e0 savoir la Bulgarie, la France, l’Allemagne, l’Irlande, les Pays-Bas et la Suisse. , le Royaume-Uni et les \u00c9tats-Unis d’Am\u00e9rique.<\/p>\n

Ils concluent que \u00ab\u00a0la transmission soutenue dans les h\u00f4pitaux de Roumanie et la propagation internationale indiquent un risque \u00e9lev\u00e9 de transmission ult\u00e9rieure de P. stuartii producteur de NDM-1 dans les \u00e9tablissements de soins de sant\u00e9. Des mesures renforc\u00e9es de pr\u00e9vention et de contr\u00f4le des infections devraient \u00eatre mises en place d\u00e8s que des cas sont d\u00e9tect\u00e9s dans les \u00e9tablissements de sant\u00e9.<\/p>\n

\t\t\t\t\t\t\t\t\t\t\t\tFourni par le Centre europ\u00e9en de pr\u00e9vention et de contr\u00f4le des maladies (ECDC)<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Les patients cherchant un traitement \u00e0 l\u2019h\u00f4pital ou dans d\u2019autres \u00e9tablissements de soins de sant\u00e9<\/p>\n","protected":false},"author":1,"featured_media":2376,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2683,2684,16,1041,1419,1331,2685,149,855],"class_list":["post-2375","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-circulation","tag-denterobacteries","tag-des","tag-etudes","tag-europe","tag-genomique","tag-multiresistantes","tag-revelent","tag-surveillance","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nDes \u00e9tudes de surveillance g\u00e9nomique r\u00e9v\u00e8lent la circulation d\u2019ent\u00e9robact\u00e9ries multir\u00e9sistantes en Europe - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/des-etudes-de-surveillance-genomique-revelent-la-circulation-denterobacteries-multiresistantes-en-europe\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Des \u00e9tudes de surveillance g\u00e9nomique r\u00e9v\u00e8lent la circulation d\u2019ent\u00e9robact\u00e9ries multir\u00e9sistantes en Europe - 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