{"id":2227,"date":"2024-11-19T01:56:24","date_gmt":"2024-11-19T00:56:24","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/un-nouveau-vaccin-nasal-semble-prometteur-pour-freiner-la-propagation-de-la-coqueluche\/"},"modified":"2024-11-19T01:56:27","modified_gmt":"2024-11-19T00:56:27","slug":"un-nouveau-vaccin-nasal-semble-prometteur-pour-freiner-la-propagation-de-la-coqueluche","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/un-nouveau-vaccin-nasal-semble-prometteur-pour-freiner-la-propagation-de-la-coqueluche\/","title":{"rendered":"Un nouveau vaccin nasal semble prometteur pour freiner la propagation de la coqueluche"},"content":{"rendered":"
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Alors que les cas de coqueluche augmentent aux \u00c9tats-Unis, un nouveau vaccin nasal d\u00e9velopp\u00e9 par l’Universit\u00e9 de Tulane pourrait \u00eatre la cl\u00e9 pour r\u00e9duire la propagation de cette maladie respiratoire hautement contagieuse.<\/p>\n

Les vaccins actuels contre la coqueluche sont largement utilis\u00e9s et efficaces pour pr\u00e9venir la coqueluche, caus\u00e9e par la bact\u00e9rie Bordetella pertussis. Cependant, les vaccins ne parviennent pas \u00e0 \u00e9liminer les bact\u00e9ries des voies respiratoires sup\u00e9rieures, permettant m\u00eame aux individus vaccin\u00e9s de propager la maladie.<\/p>\n

Le nouveau vaccin associe les antig\u00e8nes traditionnels de la coqueluche \u00e0 un adjuvant innovant appel\u00e9 T-vant, qui stimule la r\u00e9ponse immunitaire de l’organisme sp\u00e9cifiquement au niveau des voies respiratoires. Dans une \u00e9tude publi\u00e9e dans Vaccins npj<\/i>des souris immunis\u00e9es par voie intranasale avec le nouveau vaccin T-vant n’ont montr\u00e9 aucun signe de bact\u00e9rie dans les poumons et le nasopharynx (la zone sup\u00e9rieure de la gorge derri\u00e8re le nez) trois semaines apr\u00e8s l’infection. La bact\u00e9rie est rest\u00e9e r\u00e9pandue dans les voies respiratoires sup\u00e9rieures des souris ayant re\u00e7u le vaccin traditionnel par voie intramusculaire.<\/p>\n

\u00ab\u00a0En d\u00e9veloppant un vaccin qui peut non seulement prot\u00e9ger les individus mais \u00e9galement pr\u00e9venir la transmission, nous esp\u00e9rons am\u00e9liorer les vaccins existants et limiter la propagation de la coqueluche dans les communaut\u00e9s\u00a0\u00bb, a d\u00e9clar\u00e9 Lisa Morici, auteure principale de l’\u00e9tude, professeur de microbiologie et d’immunologie \u00e0 l’universit\u00e9 de Tulane. de M\u00e9decine.<\/p>\n

L’adjuvant T-vant est d\u00e9riv\u00e9 de v\u00e9sicules bact\u00e9riennes de la membrane externe, de minuscules particules qui stimulent naturellement le syst\u00e8me immunitaire. L’\u00e9tude a r\u00e9v\u00e9l\u00e9 que l’adjuvant encourageait une r\u00e9ponse immunitaire des muqueuses, stimulant l’activation des cellules immunitaires dans les voies respiratoires, essentielles pour arr\u00eater la capacit\u00e9 de colonisation de la bact\u00e9rie.<\/p>\n

L’\u00e9tude n’a \u00e9galement r\u00e9v\u00e9l\u00e9 aucun effet ind\u00e9sirable sur les tissus pulmonaires apr\u00e8s la vaccination, ce qui met en \u00e9vidence la s\u00e9curit\u00e9 du vaccin.<\/p>\n

Les r\u00e9sultats sont significatifs et surviennent \u00e0 un moment o\u00f9 les cas de coqueluche augmentent. Des donn\u00e9es r\u00e9centes des Centers for Disease Control and Prevention ont montr\u00e9 une multiplication par cinq des cas aux \u00c9tats-Unis par rapport \u00e0 l’ann\u00e9e derni\u00e8re. La maladie touche environ 24 millions de personnes par an dans le monde et touche principalement les nourrissons et les personnes dont le syst\u00e8me immunitaire est affaibli.<\/p>\n

Un vaccin capable de pr\u00e9venir avec succ\u00e8s l’infection et la transmission de la coqueluche chez l’homme pourrait jeter les bases de l’\u00e9limination compl\u00e8te de la maladie, a d\u00e9clar\u00e9 James McLachlan, co-auteur de l’\u00e9tude et professeur agr\u00e9g\u00e9 de microbiologie et d’immunologie \u00e0 la Tulane School of Medicine.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats soulignent la n\u00e9cessit\u00e9 de vaccins am\u00e9lior\u00e9s qui peuvent faire plus que simplement prot\u00e9ger l’individu\u00a0\u00bb, a d\u00e9clar\u00e9 McLachlan. \u00ab\u00a0Nous avons besoin de vaccins capables d’arr\u00eater efficacement la propagation de la bact\u00e9rie au sein des communaut\u00e9s, et cette nouvelle approche constitue un pas encourageant dans cette direction.\u00a0\u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Alors que les cas de coqueluche augmentent aux \u00c9tats-Unis, un nouveau vaccin nasal d\u00e9velopp\u00e9 par<\/p>\n","protected":false},"author":1,"featured_media":2228,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[824,670,1045,495,8,437,1008,2509,323],"class_list":["post-2227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-coqueluche","tag-freiner","tag-nasal","tag-nouveau","tag-pour","tag-prometteur","tag-propagation","tag-semble","tag-vaccin","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUn nouveau vaccin nasal semble prometteur pour freiner la propagation de la coqueluche - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/un-nouveau-vaccin-nasal-semble-prometteur-pour-freiner-la-propagation-de-la-coqueluche\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nouveau vaccin nasal semble prometteur pour freiner la propagation de la coqueluche - 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