{"id":2183,"date":"2024-11-16T18:03:36","date_gmt":"2024-11-16T17:03:36","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-carence-en-zinc-favorise-linfection-pulmonaire-a-acinetobacter-selon-une-etude-sur-la-souris\/"},"modified":"2024-11-16T18:03:39","modified_gmt":"2024-11-16T17:03:39","slug":"une-carence-en-zinc-favorise-linfection-pulmonaire-a-acinetobacter-selon-une-etude-sur-la-souris","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-carence-en-zinc-favorise-linfection-pulmonaire-a-acinetobacter-selon-une-etude-sur-la-souris\/","title":{"rendered":"Une carence en zinc favorise l\u2019infection pulmonaire \u00e0 Acinetobacter, selon une \u00e9tude sur la souris"},"content":{"rendered":"
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Une carence alimentaire en zinc favorise l’infection pulmonaire par la bact\u00e9rie Acinetobacter baumannii, l’une des principales causes de pneumonie nosocomiale, selon une \u00e9tude publi\u00e9e le 15 novembre dans la revue Microbiologie naturelle<\/i>.<\/p>\n

Une \u00e9quipe de chercheurs dirig\u00e9e par le centre m\u00e9dical de l’universit\u00e9 Vanderbilt a d\u00e9couvert un lien inattendu entre la cytokine pro-inflammatoire interleukine-13 (IL-13) et l’infection pulmonaire \u00e0 A. baumannii, et a d\u00e9montr\u00e9 que le blocage de l’IL-13 emp\u00eachait la mort associ\u00e9e \u00e0 l’infection dans un mod\u00e8le animal.<\/p>\n

Les r\u00e9sultats sugg\u00e8rent que les anticorps anti-IL-13, dont l’utilisation chez l’homme est approuv\u00e9e par la FDA, pourraient prot\u00e9ger contre la pneumonie bact\u00e9rienne chez les patients pr\u00e9sentant une carence en zinc.<\/p>\n

\u00ab\u00a0\u00c0 notre connaissance, il s’agit de la premi\u00e8re \u00e9tude montrant que la neutralisation de l’IL-13 pourrait pr\u00e9venir la mortalit\u00e9 due \u00e0 une infection bact\u00e9rienne\u00a0\u00bb, a d\u00e9clar\u00e9 Eric Skaar, Ph.D., MPH, professeur de pathologie Ernest W. Goodpasture et directeur du Vanderbilt. Institut d’infection, d’immunologie et d’inflammation.<\/p>\n

\u00ab\u00a0Cette d\u00e9couverte indique la possibilit\u00e9 d’utiliser un traitement anti-IL-13 chez les patients pr\u00e9sentant une carence en zinc et une pneumonie \u00e0 A. baumannii dans le cadre d’une approche th\u00e9rapeutique personnalis\u00e9e.\u00a0\u00bb<\/p>\n

Pr\u00e8s de 20 % de la population mondiale est expos\u00e9e \u00e0 un risque de carence en zinc, qui peut alt\u00e9rer la fonction immunitaire et constitue un facteur de risque majeur de pneumonie. L’Organisation mondiale de la sant\u00e9 consid\u00e8re la carence en zinc comme l’un des principaux facteurs de maladie et de d\u00e9c\u00e8s.<\/p>\n

Les patients \u00e0 risque de carence en zinc, en particulier les patients gravement malades et les patients \u00e2g\u00e9s, sont \u00e9galement \u00e0 risque d’infection \u00e0 A. baumannii. Les patients dans les \u00e9tablissements de soins de sant\u00e9 pr\u00e9sentent le risque d\u2019infection le plus \u00e9lev\u00e9, en particulier ceux qui sont sous respirateur, qui poss\u00e8dent des dispositifs tels que des cath\u00e9ters, qui sont dans des unit\u00e9s de soins intensifs ou qui ont des s\u00e9jours prolong\u00e9s \u00e0 l\u2019h\u00f4pital. A. baumannii devient de plus en plus r\u00e9sistante aux traitements antimicrobiens, ce qui en fait une menace critique pour la sant\u00e9 publique, a d\u00e9clar\u00e9 Skaar.<\/p>\n

Pour explorer si et comment une carence alimentaire en zinc contribue \u00e0 la pathogen\u00e8se d’A. baumannii, les chercheurs ont \u00e9tabli un mod\u00e8le murin de carence alimentaire en zinc et de pneumonie aigu\u00eb \u00e0 A. baumannii. Lauren Palmer, Ph.D., ancienne boursi\u00e8re postdoctorale au VUMC et aujourd’hui professeur adjoint de microbiologie et d’immunologie \u00e0 l’Universit\u00e9 de l’Illinois \u00e0 Chicago, a dirig\u00e9 les \u00e9tudes.<\/p>\n

Les chercheurs ont d\u00e9couvert que les souris d\u00e9ficientes en zinc pr\u00e9sentaient une charge bact\u00e9rienne accrue d\u2019A. baumannii dans les poumons, une propagation des bact\u00e9ries dans la rate et une mortalit\u00e9 plus \u00e9lev\u00e9e que les souris ayant une consommation alimentaire ad\u00e9quate de zinc.<\/p>\n

Ils ont montr\u00e9 que les souris d\u00e9ficientes en zinc produisent plus d’IL-13 lors de l’infection et que l’administration d’IL-13 \u00e0 des souris contenant suffisamment de zinc favorisait la propagation d’A. baumannii \u00e0 la rate. Le traitement par anticorps anti-IL-13 a prot\u00e9g\u00e9 les souris d\u00e9ficientes en zinc de la mort induite par A. baumannii.<\/p>\n

Les r\u00e9sultats s’ajoutent \u00e0 un ensemble croissant d’\u00e9tudes montrant que certaines carences en nutriments sont associ\u00e9es \u00e0 la production d’IL-13 et \u00e0 une r\u00e9ponse immunitaire de \u00ab type 2 \u00bb.<\/p>\n

\u00ab\u00a0L’IL-13 peut \u00eatre un facteur de risque important pour les infections pulmonaires opportunistes et nosocomiales, ce qui soutient davantage l’exploration de l’IL-13 en tant que cible de traitement\u00a0\u00bb, a not\u00e9 Skaar.<\/p>\n

Les anticorps anti-IL-13 approuv\u00e9s par la FDA (lebrikizumab et tralokinumab) ont fait l’objet de recherches approfondies en tant que traitements potentiels contre l’asthme s\u00e9v\u00e8re non contr\u00f4l\u00e9. Bien qu\u2019ils ne se soient pas r\u00e9v\u00e9l\u00e9s efficaces pour cette indication, les essais cliniques ont d\u00e9montr\u00e9 leur innocuit\u00e9.<\/p>\n

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Une carence alimentaire en zinc favorise l’infection pulmonaire par la bact\u00e9rie Acinetobacter baumannii, l’une des<\/p>\n","protected":false},"author":1,"featured_media":2184,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2537,2536,48,682,539,2276,46,1266,112,47,2056],"class_list":["post-2183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-acinetobacter","tag-carence","tag-etude","tag-favorise","tag-linfection","tag-pulmonaire","tag-selon","tag-souris","tag-sur","tag-une","tag-zinc","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne carence en zinc favorise l\u2019infection pulmonaire \u00e0 Acinetobacter, selon une \u00e9tude sur la souris - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-carence-en-zinc-favorise-linfection-pulmonaire-a-acinetobacter-selon-une-etude-sur-la-souris\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une carence en zinc favorise l\u2019infection pulmonaire \u00e0 Acinetobacter, selon une \u00e9tude sur la souris - 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