{"id":2113,"date":"2024-11-14T05:55:48","date_gmt":"2024-11-14T04:55:48","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/un-systeme-prometteur-dadministration-de-medicaments-ciblant-les-reins-enrichit-les-molecules-darn-synthetiques-et-les-petites-molecules\/"},"modified":"2024-11-14T05:55:51","modified_gmt":"2024-11-14T04:55:51","slug":"un-systeme-prometteur-dadministration-de-medicaments-ciblant-les-reins-enrichit-les-molecules-darn-synthetiques-et-les-petites-molecules","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/un-systeme-prometteur-dadministration-de-medicaments-ciblant-les-reins-enrichit-les-molecules-darn-synthetiques-et-les-petites-molecules\/","title":{"rendered":"Un syst\u00e8me prometteur d\u2019administration de m\u00e9dicaments ciblant les reins enrichit les mol\u00e9cules d\u2019ARN synth\u00e9tiques et les petites mol\u00e9cules"},"content":{"rendered":"
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Depuis sa d\u00e9couverte en 1998 et l’obtention du prix Nobel en 2006, l’interf\u00e9rence de l’acide ribonucl\u00e9ique (ARN) est devenue un outil pr\u00e9cieux permettant aux fabricants de m\u00e9dicaments de faire taire les g\u00e8nes pathog\u00e8nes. Pr\u00e8s de trois d\u00e9cennies plus tard, les fabricants de m\u00e9dicaments ont d\u00e9velopp\u00e9 six produits th\u00e9rapeutiques \u00e0 petits ARN interf\u00e9rents (ARNsi) approuv\u00e9s dans les domaines th\u00e9rapeutiques de la neurologie, du syst\u00e8me cardiovasculaire, du syst\u00e8me endocrinien et du m\u00e9tabolisme, tels que l’amylose, les polyneuropathies amylo\u00efdes familiales (FAP), l’hyperlipid\u00e9mie et d’autres maladies.<\/p>\n

L\u2019administration de th\u00e9rapies siARN \u00e0 une vari\u00e9t\u00e9 de tissus et de cellules d\u2019int\u00e9r\u00eat reste un d\u00e9fi majeur pour l\u2019application des th\u00e9rapies siARN chez l\u2019homme. L\u2019\u00e9tat actuel de la technique concerne les conjugu\u00e9s de siARN N-ac\u00e9tylgalactosamine (GalNAc-siARN), qui sont d\u00e9livr\u00e9s exclusivement au foie, limitant ainsi le nombre de maladies pouvant \u00eatre trait\u00e9es.<\/p>\n

Le d\u00e9veloppement d\u2019approches de conjugaison d\u2019ARN pour cibler les tissus extra-h\u00e9patiques est l\u2019objectif ultime de l\u2019administration de th\u00e9rapies \u00e0 base d\u2019ARN.<\/p>\n

Dans un r\u00e9cent Th\u00e9rapie mol\u00e9culaire<\/i> publication par Vikas Kumar et ses coll\u00e8gues intitul\u00e9e \u00ab\u00a0Ciblage efficace et s\u00e9lectif des reins par des conjugu\u00e9s de glucides chimiquement modifi\u00e9s\u00a0\u00bb, l’\u00e9quipe de Raman Bahal du d\u00e9partement pharmaceutique de l’\u00e9cole de pharmacie d’UConn d\u00e9montre le d\u00e9veloppement d’une nouvelle plateforme d’administration cibl\u00e9e sur les reins appel\u00e9e RENTAC-R\u00e9nal Tubule Targeting Carbohydrate.<\/p>\n

RENTAC cible le rein via la famille des r\u00e9cepteurs de la m\u00e9galine, une famille de r\u00e9cepteurs endog\u00e8nes de surface cellulaire exprim\u00e9s \u00e0 des niveaux \u00e9lev\u00e9s du c\u00f4t\u00e9 apical des cellules \u00e9pith\u00e9liales du tubule proximal (PTEC), entra\u00eenant l’internalisation des mol\u00e9cules conjugu\u00e9es.<\/p>\n

L\u2019\u00e9quipe a d\u00e9montr\u00e9 un enrichissement efficace des mol\u00e9cules d\u2019ARN synth\u00e9tiques et des petites mol\u00e9cules dans le rein, et cette plateforme pourrait \u00eatre utile pour traiter des affections telles que la fibrose r\u00e9nale. L’\u00e9quipe de Bahal a collabor\u00e9 activement avec Stefan Somlo, professeur de m\u00e9decine (n\u00e9phrologie) au CNH Long et professeur de g\u00e9n\u00e9tique \u00e0 Yale, pour confirmer que RENTAC cible le PTEC in vivo.<\/p>\n

Interrog\u00e9 sur ses travaux en laboratoire, Bahal a fait remarquer : \u00ab Le rein et les maladies associ\u00e9es sont un domaine auquel l’industrie accorde beaucoup d’attention, mais peu de syst\u00e8mes d’administration efficaces sont actuellement disponibles en clinique. Nous avons d\u00e9velopp\u00e9 un nouveau syst\u00e8me d’administration de glucides. conjugu\u00e9 bas\u00e9 sur la chimie qui peut d\u00e9livrer des traitements \u00e0 base d’ARN et m\u00eame de petites mol\u00e9cules au rein.<\/p>\n

\u00ab\u00a0Les possibilit\u00e9s d’application de la m\u00e9decine g\u00e9n\u00e9tique aux maladies r\u00e9nales se multiplient\u00a0\u00bb, d\u00e9clare Somlo. \u00ab\u00a0L’un des obstacles au progr\u00e8s translationnel est la capacit\u00e9 limit\u00e9e \u00e0 cibler des th\u00e9rapies visant \u00e0 augmenter l’administration dans les tissus r\u00e9naux.<\/p>\n

\u00ab La collaboration entre notre groupe \u00e0 Yale et le groupe de Bahal \u00e0 UConn rassemble notre expertise dans la d\u00e9couverte de cibles th\u00e9rapeutiques avec la d\u00e9couverte unique de Bahal sur la fa\u00e7on d’administrer des m\u00e9dicaments au rein. Les synergies dans notre travail ensemble offrent vraiment une opportunit\u00e9 passionnante de d\u00e9velopper un paradigme sur la fa\u00e7on de concevoir et de fournir de nouveaux traitements aux patients atteints d’insuffisance r\u00e9nale.<\/p>\n

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Depuis sa d\u00e9couverte en 1998 et l’obtention du prix Nobel en 2006, l’interf\u00e9rence de l’acide<\/p>\n","protected":false},"author":1,"featured_media":2114,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2464,2463,2468,2466,49,87,2467,2470,437,2465,2469,843],"class_list":["post-2113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-ciblant","tag-dadministration","tag-darn","tag-enrichit","tag-les","tag-medicaments","tag-molecules","tag-petites","tag-prometteur","tag-reins","tag-synthetiques","tag-systeme","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUn syst\u00e8me prometteur d\u2019administration de m\u00e9dicaments ciblant les reins enrichit les mol\u00e9cules d\u2019ARN synth\u00e9tiques et les petites mol\u00e9cules - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/un-systeme-prometteur-dadministration-de-medicaments-ciblant-les-reins-enrichit-les-molecules-darn-synthetiques-et-les-petites-molecules\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un syst\u00e8me prometteur d\u2019administration de m\u00e9dicaments ciblant les reins enrichit les mol\u00e9cules d\u2019ARN synth\u00e9tiques et les petites mol\u00e9cules - 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