{"id":20824,"date":"2026-10-30T21:11:30","date_gmt":"2026-10-30T20:11:30","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/cellules-zombies-pourquoi-le-cancer-reapparait-souvent-apres-une-chimiotherapie\/"},"modified":"2026-10-30T21:11:31","modified_gmt":"2026-10-30T20:11:31","slug":"cellules-zombies-pourquoi-le-cancer-reapparait-souvent-apres-une-chimiotherapie","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/cellules-zombies-pourquoi-le-cancer-reapparait-souvent-apres-une-chimiotherapie\/","title":{"rendered":"\u00ab\u00a0Cellules zombies\u00a0\u00bb\u00a0: pourquoi le cancer r\u00e9appara\u00eet souvent apr\u00e8s une chimioth\u00e9rapie"},"content":{"rendered":"<p><!--$--><br \/>\n<!--\/--><br \/>\n<!--$--><\/p>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>La chimioth\u00e9rapie est notre arme la plus importante contre le cancer. Id\u00e9alement, les agents cytotoxiques tuent les cellules tumorales en endommageant leur ADN. Cela active le programme de suicide cellulaire dans les cellules tumorales et celles-ci meurent. Malheureusement, cela ne fonctionne pas de mani\u00e8re transparente : certaines cellules canc\u00e9reuses survivent \u00e0 la chimioth\u00e9rapie. Dans le meilleur des cas, notre syst\u00e8me immunitaire intervient alors et tue lui-m\u00eame les cellules canc\u00e9reuses restantes.<\/p>\n<\/div>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-mobile Ad-Slot-hor Ad-Slot-FC\">\n<div class=\"Ad-Slot-FC-Container \" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\">\n<div class=\"Ad-Slot-FC-Window\">\n<div id=\"ad-slot-mobile-hor-2\" data-orientation=\"hor\" data-index=\"2\" data-slot=\"ad-slot\" data-device=\"mobile\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<h2>Comment les cellules canc\u00e9reuses survivantes trompent le syst\u00e8me immunitaire<\/h2>\n<p>Mais les choses se passent souvent diff\u00e9remment : au lieu de mourir, certaines des cellules canc\u00e9reuses restantes subissent un changement radical apr\u00e8s la chimioth\u00e9rapie. Ils grandissent jusqu\u2019\u00e0 dix fois leur taille et arr\u00eatent de se diviser \u2013 ils entrent dans un \u00e9tat de survie. <\/p>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>En raison de cette s\u00e9nescence pr\u00e9matur\u00e9e, les cellules canc\u00e9reuses transform\u00e9es par la chimioth\u00e9rapie sont largement immunis\u00e9es contre les attaques du syst\u00e8me immunitaire ainsi que contre les m\u00e9dicaments de chimioth\u00e9rapie. <\/p>\n<\/div>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-mobile Ad-Slot-out\">\n<div id=\"ad-slot-mobile-out-1\" data-orientation=\"out\" data-index=\"1\" data-slot=\"ad-slot\" data-device=\"mobile\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\"><\/div>\n<\/aside>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<blockquote>\n<p>\u00ab\u00a0Ces cellules peuvent conduire au retour des tumeurs canc\u00e9reuses\u00a0\u00bb, expliquent Gokhan Gunay du Trinity College de Dublin et ses coll\u00e8gues.<\/p>\n<\/blockquote>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>Pour ce faire, les \u00ab cellules zombies \u00bb utilisent une astuce : elles activent de nombreux g\u00e8nes qui sont normalement lus dans les cellules du corps bless\u00e9es et qui ont besoin d&rsquo;\u00eatre r\u00e9par\u00e9es. Les cellules canc\u00e9reuses converties lib\u00e8rent diverses substances messag\u00e8res qui simulent une blessure. <\/p>\n<\/div>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-mobile Ad-Slot-hor\">\n<div id=\"ad-slot-mobile-hor-3\" data-orientation=\"hor\" data-index=\"3\" data-slot=\"ad-slot\" data-device=\"mobile\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\"><\/div>\n<\/aside>\n<div class=\"Ad-Carousel mb-xl row \" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\">\n<div class=\"col-lg-4\">\n<div data-qa-ad-slot=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Ad-Slot Ad-Slot-desktop Ad-Slot-ver \" role=\"region\" aria-label=\"Anzeige 1\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\">\n<div id=\"ad-slot-desktop-ver-1\" data-orientation=\"ver\" data-index=\"1\" data-slot=\"ad-slot\" data-device=\"desktop\"><\/div>\n<\/div>\n<\/div>\n<div class=\"col-lg-4\">\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-desktop Ad-Slot-ver Ad-Slot-FC\">\n<div class=\"Ad-Slot-FC-Container \" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\">\n<div class=\"Ad-Slot-FC-Window\">\n<div id=\"ad-slot-desktop-ver-2\" data-orientation=\"ver\" data-index=\"2\" data-slot=\"ad-slot\" data-device=\"desktop\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<\/div>\n<div class=\"col-lg-4\">\n<div data-qa-ad-slot=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Ad-Slot Ad-Slot-desktop Ad-Slot-ver \" role=\"region\" aria-label=\"Anzeige 3\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\">\n<div id=\"ad-slot-desktop-ver-3\" data-orientation=\"ver\" data-index=\"3\" data-slot=\"ad-slot\" data-device=\"desktop\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>Cela incite le syst\u00e8me immunitaire \u00e0 r\u00e9parer les dommages tissulaires suppos\u00e9s : cela stimule la division cellulaire et la formation de nouveaux vaisseaux sanguins qui transportent les nutriments et l&rsquo;oxyg\u00e8ne vers les cellules canc\u00e9reuses pr\u00e9tendument endommag\u00e9es. Une d\u00e9fense immunitaire malavis\u00e9e aide les cellules canc\u00e9reuses survivantes \u00e0 se d\u00e9velopper \u00e0 nouveau et \u00e0 former de nouvelles tumeurs.<\/p>\n<\/div>\n<div class=\"mb-lg\">\n<div data-qa-article-image class=\"Article-Image\">\n<figure class=\"Article-Content-Figure\"><!--$--><!--\/--><!--$--><\/p>\n<div class=\"Image-Container\" data-qa-image-container><\/div>\n<p><!--\/--><!--$--><figcaption class=\"Article-Content-Figcaption\"><span data-qa-image-caption class=\"Image-Caption\"> <!--$-->La fluorescence vert vif de ces cellules canc\u00e9reuses s\u00e9nescentes indique l\u2019inhibiteur de l\u2019apoptose qu\u2019elles produisent \u2013 \u200b\u200bles prot\u00e9ines qui emp\u00eachent la mort cellulaire.<!--\/--> <\/span><span data-qa-image-credit class=\"Image-Credit\"> <!--$-->Seamus Martin\/Trinity College de Dublin<!--\/--> <!--$--><!--\/--><\/span><\/figcaption><!--\/--><\/figure>\n<\/div>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<h2>Protection contre la mort cellulaire par les inhibiteurs de l&rsquo;apoptose<\/h2>\n<p>Ce processus peut provoquer la r\u00e9apparition du cancer m\u00eame apr\u00e8s une chimioth\u00e9rapie apparemment r\u00e9ussie. <\/p>\n<\/div>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-mobile Ad-Slot-hor\">\n<div id=\"ad-slot-mobile-hor-4\" data-orientation=\"hor\" data-index=\"4\" data-slot=\"ad-slot\" data-device=\"mobile\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\"><\/div>\n<\/aside>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<blockquote>\n<p>\u00ab\u00a0Il est donc important de d\u00e9couvrir comment les tumeurs \u00e9chappent aux effets destructeurs de cellules de la chimioth\u00e9rapie et entrent dans un \u00e9tat de s\u00e9nescence\u00a0\u00bb, explique l&rsquo;auteur principal Seamus Martin du Trinity College de Dublin. <\/p>\n<\/blockquote>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>Pour leur \u00e9tude, lui et son \u00e9quipe ont expos\u00e9 des cultures de cellules canc\u00e9reuses \u00e0 la chimioth\u00e9rapie, puis ont analys\u00e9 en d\u00e9tail le m\u00e9tabolisme cellulaire des cellules zombies survivantes.<\/p>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>Les analyses ont r\u00e9v\u00e9l\u00e9 : En r\u00e9ponse \u00e0 une chimioth\u00e9rapie endommageant les cellules, certaines cellules tumorales produisent ce qu&rsquo;on appelle des inhibiteurs de l&rsquo;apoptose (IAP) &#8211; des prot\u00e9ines qui inhibent le programme suicide de la cellule. Ces inhibiteurs emp\u00eachent les cellules canc\u00e9reuses affect\u00e9es de former ce que l\u2019on appelle des \u00ab r\u00e9cepteurs de la mort \u00bb \u2013 des points d\u2019accueil pour les enzymes destructrices de cellules. Pour la premi\u00e8re fois, Gunay et son \u00e9quipe ont pu d\u00e9chiffrer la cha\u00eene complexe de r\u00e9actions qui conduit \u00e0 la formation de ces inhibiteurs de l&rsquo;apoptose. Ils ont ainsi identifi\u00e9 le m\u00e9canisme par lequel certaines cellules tumorales \u00e9chappent \u00e0 la mort cellulaire.<\/p>\n<\/div>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-mobile Ad-Slot-hor\">\n<div id=\"ad-slot-mobile-hor-5\" data-orientation=\"hor\" data-index=\"5\" data-slot=\"ad-slot\" data-device=\"mobile\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\"><\/div>\n<\/aside>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-desktop Ad-Slot-hor Ad-Slot-FC\">\n<div class=\"Ad-Slot-FC-Container \" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\">\n<div class=\"Ad-Slot-FC-Window\">\n<div id=\"ad-slot-desktop-hor-2\" data-orientation=\"hor\" data-index=\"2\" data-slot=\"ad-slot\" data-device=\"desktop\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<h2>Comment pr\u00e9venir les \u00ab\u00a0cellules zombies\u00a0\u00bb<\/h2>\n<p>Mais ce qui est encore plus important, c&rsquo;est que Gunay et son \u00e9quipe ont \u00e9galement trouv\u00e9 de nouveaux points de d\u00e9part pour lutter contre la formation de telles cellules zombies. Lors d\u2019exp\u00e9riences sur des souris, ils ont r\u00e9ussi \u00e0 \u00e9liminer ces cellules pr\u00e9matur\u00e9ment s\u00e9nescentes gr\u00e2ce \u00e0 certains principes actifs. Ces principes actifs neutralisent les inhibiteurs de l\u2019apoptose produits par les cellules canc\u00e9reuses, les emp\u00eachant ainsi d\u2019\u00e9chapper \u00e0 la mort cellulaire. <\/p>\n<\/div>\n<aside data-qa-ad-slot class=\"Ad-Slot Ad-Slot-mobile Ad-Slot-hor\">\n<div id=\"ad-slot-mobile-hor-6\" data-orientation=\"hor\" data-index=\"6\" data-slot=\"ad-slot\" data-device=\"mobile\" data-nosnippet=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\"><\/div>\n<\/aside>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<blockquote>\n<p>\u00ab\u00a0La d\u00e9pendance des cellules canc\u00e9reuses s\u00e9nescentes vis-\u00e0-vis de mol\u00e9cules telles que l&rsquo;IAP et le FLIPL est leur point faible\u00a0\u00bb, expliquent les chercheurs.<\/p>\n<\/blockquote>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>Les r\u00e9sultats fournissent donc des informations importantes pour des th\u00e9rapies anticanc\u00e9reuses plus efficaces : si les patients recevaient des m\u00e9dicaments contre les inhibiteurs de l&rsquo;apoptose imm\u00e9diatement apr\u00e8s la chimioth\u00e9rapie, cela pourrait emp\u00eacher les cellules tumorales d&rsquo;entrer dans un \u00e9tat de s\u00e9nescence. \u00ab\u00a0Cela pourrait tuer davantage de cellules tumorales\u00a0\u00bb, explique Martin. Cependant, il reste encore \u00e0 tester quels principes actifs peuvent \u00eatre utilis\u00e9s chez l\u2019homme.<\/p>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p>Par Nadja Podbregar<\/p>\n<\/div>\n<div data-qa-article-content-text=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" data-text-milestone-block=\"https:\/\/www.focus.de\/gesundheit\/ratgeber\/true\" class=\"Html-Block \">\n<p><i>L&rsquo;original de cet article \u00ab \u00ab\u00a0Cellules zombies\u00a0\u00bb\u00a0: pourquoi le cancer r\u00e9appara\u00eet souvent apr\u00e8s une chimioth\u00e9rapie\u00a0\u00bb vient de Wissenschaft.de.<\/i><\/p>\n<\/div>\n<p><!--\/--><br \/>\n<!--$--><br \/>\n<!--\/--><br \/>\n<!--$--><br \/>\n<!--\/--><br \/>\n<!--$--><br \/>\n<!--\/--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La chimioth\u00e9rapie est notre arme la plus importante contre le cancer. Id\u00e9alement, les agents cytotoxiques<\/p>\n","protected":false},"author":1,"featured_media":20825,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[217,391,1622,11236,2019,11235,2892,47,5066],"class_list":["post-20824","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-apres","tag-cancer","tag-cellules","tag-chimiotherapie","tag-pourquoi","tag-reapparait","tag-souvent","tag-une","tag-zombies","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00ab\u00a0Cellules zombies\u00a0\u00bb\u00a0: pourquoi le cancer r\u00e9appara\u00eet souvent apr\u00e8s une chimioth\u00e9rapie - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/cellules-zombies-pourquoi-le-cancer-reapparait-souvent-apres-une-chimiotherapie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00ab\u00a0Cellules zombies\u00a0\u00bb\u00a0: pourquoi le cancer r\u00e9appara\u00eet souvent apr\u00e8s une chimioth\u00e9rapie - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"La chimioth\u00e9rapie est notre arme la plus importante contre le cancer. 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