{"id":2001,"date":"2024-11-09T14:02:36","date_gmt":"2024-11-09T13:02:36","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/le-sras-cov-2-vole-nos-proteines-pour-se-proteger-du-systeme-immunitaire-revele-une-etude\/"},"modified":"2024-11-09T14:02:38","modified_gmt":"2024-11-09T13:02:38","slug":"le-sras-cov-2-vole-nos-proteines-pour-se-proteger-du-systeme-immunitaire-revele-une-etude","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/le-sras-cov-2-vole-nos-proteines-pour-se-proteger-du-systeme-immunitaire-revele-une-etude\/","title":{"rendered":"Le SRAS-CoV-2 \u00ab vole \u00bb nos prot\u00e9ines pour se prot\u00e9ger du syst\u00e8me immunitaire, r\u00e9v\u00e8le une \u00e9tude"},"content":{"rendered":"
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Des chercheurs de l\u2019Universit\u00e9 de m\u00e9decine de Vienne et de l\u2019Universit\u00e9 de m\u00e9decine d\u2019Innsbruck ont \u200b\u200bd\u00e9couvert que le SRAS-CoV-2 d\u00e9tourne trois prot\u00e9ines h\u00f4tes importantes qui att\u00e9nuent l\u2019activit\u00e9 du syst\u00e8me du compl\u00e9ment, un \u00e9l\u00e9ment cl\u00e9 de l\u2019immunit\u00e9 antivirale pr\u00e9coce.<\/p>\n

Cela alt\u00e8re consid\u00e9rablement la clairance virale, ce qui peut affecter l\u2019\u00e9volution \u00e0 la fois des infections aigu\u00ebs au COVID-19 et des s\u00e9quelles post-COVID-19. L’\u00e9tude est publi\u00e9e dans la revue Microbes et infections \u00e9mergents<\/i>.<\/p>\n

Une r\u00e9ponse immunitaire pr\u00e9coce et efficace est cruciale pour r\u00e9soudre les infections virales et pr\u00e9venir les complications post-infectieuses. Le syst\u00e8me du compl\u00e9ment, \u00e9l\u00e9ment essentiel de l\u2019immunit\u00e9 antivirale, est une cascade de prot\u00e9ines pr\u00e9sentes dans la circulation sanguine et au niveau des muqueuses, telles que les voies respiratoires.<\/p>\n

Activ\u00e9 par trois voies diff\u00e9rentes, le compl\u00e9ment facilite l’\u00e9limination des particules virales en induisant directement leur destruction (lyse). Pour \u00e9viter les dommages caus\u00e9s aux cellules h\u00f4tes, le compl\u00e9ment est rapidement inactiv\u00e9 par un ensemble de mol\u00e9cules h\u00f4tes appel\u00e9es prot\u00e9ines r\u00e9gulatrices du compl\u00e9ment.<\/p>\n

L’\u00e9tude dirig\u00e9e par Anna Ohradanova-Repic et ses coll\u00e8gues du Centre de physiopathologie, d’infectiologie et d’immunologie de l’Universit\u00e9 de m\u00e9decine de Vienne en collaboration avec l’\u00e9quipe d’Heribert Stoiber de l’Institut de virologie de l’Universit\u00e9 de m\u00e9decine d’Innsbruck montre que le SRAS-CoV- 2 d\u00e9tourne trois de ces prot\u00e9ines r\u00e9gulatrices, CD55, CD59 et le facteur H, et se prot\u00e8ge ainsi avec succ\u00e8s de la lyse m\u00e9di\u00e9e par le compl\u00e9ment.<\/p>\n

D\u00e9tournement des prot\u00e9ines de l\u2019h\u00f4te pour une r\u00e9sistance efficace au compl\u00e9ment<\/h2>\n

En propageant le SRAS-CoV-2 dans les cellules humaines, les chercheurs ont d\u00e9couvert que les particules virales acqui\u00e8rent les prot\u00e9ines cellulaires CD55 et CD59. D\u2019autres exp\u00e9riences ont montr\u00e9 que le SRAS-CoV-2 se lie \u00e9galement au facteur H, une autre prot\u00e9ine r\u00e9gulatrice du compl\u00e9ment que l\u2019on trouve principalement dans la circulation sanguine.<\/p>\n

La confrontation des particules virales avec le compl\u00e9ment actif a r\u00e9v\u00e9l\u00e9 qu’elles sont partiellement r\u00e9sistantes \u00e0 la lyse m\u00e9di\u00e9e par le compl\u00e9ment. En supprimant CD55, CD59 et le facteur H de la surface du virus ou en inhibant leurs fonctions biologiques, les chercheurs pourraient r\u00e9ussir \u00e0 restaurer la clairance m\u00e9di\u00e9e par le compl\u00e9ment du SRAS-CoV-2.<\/p>\n

\u00ab\u00a0En d\u00e9tournant ces trois prot\u00e9ines, le SRAS-CoV-2 peut \u00e9chapper aux trois voies du compl\u00e9ment, ce qui entra\u00eene une clairance virale r\u00e9duite ou retard\u00e9e par l’h\u00f4te infect\u00e9\u00a0\u00bb, explique Anna Ohradanova-Repic, responsable de l’\u00e9tude.<\/p>\n

\u00c9tant donn\u00e9 que le compl\u00e9ment est \u00e9troitement li\u00e9 \u00e0 d\u2019autres composants du syst\u00e8me immunitaire, cela affecte non seulement l\u2019\u00e9limination du virus, mais peut \u00e9galement provoquer une inflammation importante, une caract\u00e9ristique essentielle \u00e0 la fois du COVID-19 grave et du COVID long.<\/p>\n

\u00ab\u00a0D\u00e9couvrir les m\u00e9canismes d’\u00e9vasion immunitaire qui permettent au virus de persister plus longtemps dans l’h\u00f4te, approfondit notre compr\u00e9hension des impacts aigus et \u00e0 long terme de l’infection par le SRAS-CoV-2\u00a0\u00bb, explique la premi\u00e8re auteure Laura Gebetsberger.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de l\u2019Universit\u00e9 de m\u00e9decine de Vienne et de l\u2019Universit\u00e9 de m\u00e9decine d\u2019Innsbruck ont<\/p>\n","protected":false},"author":1,"featured_media":2002,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[48,834,2062,8,218,1204,157,1913,843,47,2360],"class_list":["post-2001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-etude","tag-immunitaire","tag-nos","tag-pour","tag-proteger","tag-proteines","tag-revele","tag-srascov2","tag-systeme","tag-une","tag-vole","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nLe SRAS-CoV-2 \u00ab vole \u00bb nos prot\u00e9ines pour se prot\u00e9ger du syst\u00e8me immunitaire, r\u00e9v\u00e8le une \u00e9tude - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/le-sras-cov-2-vole-nos-proteines-pour-se-proteger-du-systeme-immunitaire-revele-une-etude\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le SRAS-CoV-2 \u00ab vole \u00bb nos prot\u00e9ines pour se prot\u00e9ger du syst\u00e8me immunitaire, r\u00e9v\u00e8le une \u00e9tude - 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