{"id":1989,"date":"2024-11-08T21:58:01","date_gmt":"2024-11-08T20:58:01","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-etude-sur-les-biomarqueurs-confirme-lefficacite-de-hnl-dimer-dans-la-surveillance-du-traitement-du-sepsis\/"},"modified":"2024-11-08T21:58:05","modified_gmt":"2024-11-08T20:58:05","slug":"une-etude-sur-les-biomarqueurs-confirme-lefficacite-de-hnl-dimer-dans-la-surveillance-du-traitement-du-sepsis","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-etude-sur-les-biomarqueurs-confirme-lefficacite-de-hnl-dimer-dans-la-surveillance-du-traitement-du-sepsis\/","title":{"rendered":"Une \u00e9tude sur les biomarqueurs confirme l’efficacit\u00e9 de HNL Dimer dans la surveillance du traitement du sepsis"},"content":{"rendered":"
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Il a d\u00e9j\u00e0 \u00e9t\u00e9 d\u00e9montr\u00e9 que le biomarqueur lipocaline HNL des neutrophiles humains \u00e9tait un indicateur utile des infections bact\u00e9riennes. D\u00e9sormais, la forme dim\u00e8re de HNL peut \u00e9galement \u00eatre utilis\u00e9e pour surveiller efficacement le succ\u00e8s du traitement antibiotique du sepsis.<\/p>\n

Les premiers r\u00e9sultats prometteurs \u00e0 cet \u00e9gard ont \u00e9t\u00e9 publi\u00e9s en 2019, et le groupe de recherche a maintenant confirm\u00e9 ces r\u00e9sultats dans une \u00e9tude plus vaste. La nouvelle \u00e9tude est publi\u00e9e dans la revue PLOS UN<\/i>.<\/p>\n

La septic\u00e9mie, la maladie la plus co\u00fbteuse en soins de sant\u00e9, est une maladie potentiellement mortelle avec une mortalit\u00e9 \u00e9lev\u00e9e si elle n’est pas diagnostiqu\u00e9e et trait\u00e9e t\u00f4t et efficacement. La cause est principalement une infection bact\u00e9rienne. Ainsi, un traitement antibiotique pr\u00e9coce et efficace sauve des vies. L\u2019utilisation d\u2019antibiotiques \u00e0 large spectre augmente la probabilit\u00e9 d\u2019un traitement efficace mais peut \u00e9galement favoriser le d\u00e9veloppement d\u2019une r\u00e9sistance aux antibiotiques.<\/p>\n

Le Forum \u00e9conomique mondial de 2013 a class\u00e9 la r\u00e9sistance aux antibiotiques comme l\u2019une des plus grandes menaces pour la sant\u00e9 mondiale. 1,27 millions de d\u00e9c\u00e8s ont \u00e9t\u00e9 caus\u00e9s directement par la r\u00e9sistance aux antimicrobiens en 2019 et 13,66 millions avaient la septic\u00e9mie comme cause imm\u00e9diate ou interm\u00e9diaire de d\u00e9c\u00e8s.<\/p>\n

Dans la nouvelle \u00e9tude, les scientifiques voulaient v\u00e9rifier si l’utilisation du HNL Dimer comme biomarqueur sanguin serait utile dans la surveillance du traitement antibiotique des patients atteints de sepsis et fournirait une r\u00e9ponse plus fiable et plus rapide que les biomarqueurs actuellement utilis\u00e9s.<\/p>\n

L’enqu\u00eate a \u00e9t\u00e9 men\u00e9e sur 277 patients admis en unit\u00e9 de soins intensifs. Du sang a \u00e9t\u00e9 pr\u00e9lev\u00e9 \u00e0 l\u2019admission et les trois jours cons\u00e9cutifs suivants, puis analys\u00e9 en laboratoire. \u00c0 des fins de comparaison avec HNL Dimer, plusieurs autres biomarqueurs sanguins ont \u00e9t\u00e9 analys\u00e9s dans le but de suivre leur cin\u00e9tique lors d’un traitement antibiotique r\u00e9ussi. Il s\u2019agit de la procalcitonine, de la prot\u00e9ine liant l\u2019h\u00e9parine et de la CRP (prot\u00e9ine C-r\u00e9active) et sont toutes tr\u00e8s \u00e9lev\u00e9es dans le sang chez les patients atteints d\u2019infections bact\u00e9riennes telles que la septic\u00e9mie.<\/p>\n

\u00ab\u00a0Le probl\u00e8me, cependant, avec ces biomarqueurs est qu’il faut souvent 4 \u00e0 5 jours de traitement r\u00e9ussi avant de constater une r\u00e9duction des taux sanguins. Les taux de HNL Dimer sont r\u00e9duits beaucoup plus rapidement et souvent dans la journ\u00e9e suivant un traitement antibiotique r\u00e9ussi.<\/p>\n

\u00ab\u00a0Ainsi, en mesurant le HNL Dimer dans le sang de nos patients, nous pourrions gagner un temps important de 3 \u00e0 4 jours avant de conna\u00eetre le r\u00e9sultat de notre traitement antibiotique\u00a0\u00bb, d\u00e9clare Per Venge, MD et professeur de chimie clinique \u00e0 l’Universit\u00e9 d’Uppsala en Su\u00e8de et qui m\u00e8ne des recherches depuis de nombreuses ann\u00e9es sur la lipocaline neutrophile humaine en tant que biomarqueur de maladie.<\/p>\n

Le test HNL Dimer est d\u00e9velopp\u00e9 en \u00e9troite collaboration entre l\u2019Universit\u00e9 d\u2019Uppsala et la soci\u00e9t\u00e9 Diagnostics Development \u00e0 Uppsala.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Il a d\u00e9j\u00e0 \u00e9t\u00e9 d\u00e9montr\u00e9 que le biomarqueur lipocaline HNL des neutrophiles humains \u00e9tait un<\/p>\n","protected":false},"author":1,"featured_media":1990,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[797,1136,44,2348,48,2347,1137,49,1235,112,855,261,47],"class_list":["post-1989","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-biomarqueurs","tag-confirme","tag-dans","tag-dimer","tag-etude","tag-hnl","tag-lefficacite","tag-les","tag-sepsis","tag-sur","tag-surveillance","tag-traitement","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne \u00e9tude sur les biomarqueurs confirme l'efficacit\u00e9 de HNL Dimer dans la surveillance du traitement du sepsis - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-etude-sur-les-biomarqueurs-confirme-lefficacite-de-hnl-dimer-dans-la-surveillance-du-traitement-du-sepsis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une \u00e9tude sur les biomarqueurs confirme l'efficacit\u00e9 de HNL Dimer dans la surveillance du traitement du sepsis - 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