{"id":1858,"date":"2024-11-04T06:14:56","date_gmt":"2024-11-04T05:14:56","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/demeler-le-lien-entre-lhepatite-et-les-lesions-renales\/"},"modified":"2024-11-04T06:15:08","modified_gmt":"2024-11-04T05:15:08","slug":"demeler-le-lien-entre-lhepatite-et-les-lesions-renales","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/demeler-le-lien-entre-lhepatite-et-les-lesions-renales\/","title":{"rendered":"D\u00e9m\u00ealer le lien entre l\u2019h\u00e9patite et les l\u00e9sions r\u00e9nales"},"content":{"rendered":"
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Le virus de l’h\u00e9patite E affecte le foie. Mais les cellules h\u00e9patiques infect\u00e9es s\u00e9cr\u00e8tent une prot\u00e9ine virale qui r\u00e9agit avec les anticorps pr\u00e9sents dans le sang et peut former des complexes susceptibles d’endommager la structure filtrante des reins, comme l’ont prouv\u00e9 pour la premi\u00e8re fois des chercheurs de l’Universit\u00e9 de Zurich et de l’H\u00f4pital universitaire de Zurich.<\/p>\n

Le virus de l\u2019h\u00e9patite E infecte chaque ann\u00e9e quelque 70 millions de personnes. \u00ab\u00a0Cette infection est la forme la plus courante d’h\u00e9patite aigu\u00eb et un probl\u00e8me de sant\u00e9 mondial majeur\u00a0\u00bb, explique Achim Weber, professeur de pathologie \u00e0 l’Universit\u00e9 de Zurich (UZH) et \u00e0 l’H\u00f4pital universitaire de Zurich. Dans la majorit\u00e9 des cas, l\u2019infection est asymptomatique ou b\u00e9nigne. Cependant, cela implique parfois non seulement de graves dommages au foie, mais \u00e9galement aux reins.<\/p>\n

Avoir un aper\u00e7u du m\u00e9canisme de la maladie<\/h2>\n

\u00ab\u00a0Nous le savons depuis longtemps, mais personne ne comprenait exactement pourquoi\u00a0\u00bb, d\u00e9clare Weber. Aujourd’hui, deux sp\u00e9cialistes en pathologie r\u00e9nale, Birgit Helmchen et Ariana Gaspert, et la biologiste mol\u00e9culaire Anne-Laure Leblond de l’\u00e9quipe de Weber, en collaboration avec des chercheurs fran\u00e7ais et des coll\u00e8gues de divers h\u00f4pitaux suisses, ont acquis un aper\u00e7u du m\u00e9canisme sous-jacent de la maladie bas\u00e9 sur les tissus. des \u00e9chantillons provenant de patients. L’ouvrage est publi\u00e9 dans Communications naturelles<\/i>.<\/p>\n

Les cellules h\u00e9patiques infect\u00e9es produisent un exc\u00e8s d\u2019une prot\u00e9ine virale qui peut se lier \u00e0 d\u2019autres prot\u00e9ines virales pour former une enveloppe virale. Parce que le mat\u00e9riel g\u00e9n\u00e9tique du virus se r\u00e9plique dans une bien moindre mesure, la grande majorit\u00e9 des enveloppes restent vides lorsqu’elles sont s\u00e9cr\u00e9t\u00e9es par les cellules h\u00e9patiques. C\u2019est ainsi qu\u2019ils p\u00e9n\u00e8trent dans la circulation sanguine, o\u00f9 ils sont d\u00e9tect\u00e9s par le syst\u00e8me immunitaire, qui forme alors des anticorps qui se collent aux prot\u00e9ines virales.<\/p>\n

Ces complexes enveloppe virale-anticorps se d\u00e9posent ensuite dans les structures filtrantes des reins, appel\u00e9es glom\u00e9rules. Si les complexes s\u2019accumulent plus rapidement qu\u2019ils ne sont \u00e9limin\u00e9s, ils peuvent endommager les glom\u00e9rules, d\u00e9clenchant ce que l\u2019on appelle la glom\u00e9rulon\u00e9phrite, un type de l\u00e9sion qui, dans le pire des cas, peut conduire \u00e0 une insuffisance r\u00e9nale.<\/p>\n

L’h\u00e9patite E reste souvent non diagnostiqu\u00e9e<\/h2>\n

L’\u00e9quipe de chercheurs de Weber a d\u00e9couvert ce m\u00e9canisme en examinant la cause du d\u00e9c\u00e8s d’un patient qui avait re\u00e7u un nouveau rein des ann\u00e9es plus t\u00f4t. \u00ab\u00a0D’apr\u00e8s le dossier m\u00e9dical du patient, il \u00e9tait clair que son h\u00e9patite E chronique n’avait pas \u00e9t\u00e9 diagnostiqu\u00e9e imm\u00e9diatement\u00a0\u00bb, explique Weber. Ce n’est pas rare, explique Weber, car cette maladie re\u00e7oit encore trop peu d’attention ici en Europe.<\/p>\n

\u00ab\u00a0Quand j’\u00e9tais \u00e9tudiant en m\u00e9decine, on nous enseignait que l’h\u00e9patite E ne touchait que les personnes vivant en Asie, en Afrique et en Am\u00e9rique centrale\u00a0\u00bb, explique Weber. On r\u00e9alise d\u00e9sormais progressivement que les Europ\u00e9ens peuvent \u00e9galement contracter le virus de l\u2019h\u00e9patite E, en particulier si leur syst\u00e8me immunitaire est affaibli, et que l\u2019infection peut donc s\u2019installer et devenir chronique.<\/p>\n

M\u00e9thodes de d\u00e9tection pr\u00e9cieuses<\/h2>\n

\u00ab\u00a0Nous esp\u00e9rons que notre d\u00e9couverte contribuera \u00e0 sensibiliser le public \u00e0 l’h\u00e9patite E, y compris ici en Suisse\u00a0\u00bb, d\u00e9clare Weber. Les r\u00e9sultats r\u00e9cemment publi\u00e9s sont \u00e9galement importants pour les diagnostics quotidiens. Gr\u00e2ce aux m\u00e9thodes d\u00e9velopp\u00e9es par Weber et son \u00e9quipe pour d\u00e9tecter les prot\u00e9ines de l’h\u00e9patite E, les pathologistes peuvent d\u00e9sormais d\u00e9terminer si le virus est impliqu\u00e9 dans la glom\u00e9rulon\u00e9phrite.<\/p>\n

\u00ab\u00a0Cela profitera aux personnes concern\u00e9es\u00a0\u00bb, d\u00e9clare Weber. En effet, si la maladie est effectivement caus\u00e9e par le virus de l’h\u00e9patite E, les \u00e9quipes m\u00e9dicales peuvent prendre des mesures \u00e0 temps, par exemple en administrant des substances pour arr\u00eater la r\u00e9plication du virus, et ainsi pr\u00e9venir une insuffisance r\u00e9nale imminente.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Le virus de l’h\u00e9patite E affecte le foie. Mais les cellules h\u00e9patiques infect\u00e9es s\u00e9cr\u00e8tent une<\/p>\n","protected":false},"author":1,"featured_media":1859,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[2214,159,49,2215,1058,2071,2014],"class_list":["post-1858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-demeler","tag-entre","tag-les","tag-lesions","tag-lhepatite","tag-lien","tag-renales","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nD\u00e9m\u00ealer le lien entre l\u2019h\u00e9patite et les l\u00e9sions r\u00e9nales - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/demeler-le-lien-entre-lhepatite-et-les-lesions-renales\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9m\u00ealer le lien entre l\u2019h\u00e9patite et les l\u00e9sions r\u00e9nales - RVH-Synergie.org\" \/>\n<meta property=\"og:description\" content=\"Le virus de l’h\u00e9patite E affecte le foie. 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