{"id":1717,"date":"2024-10-29T10:09:02","date_gmt":"2024-10-29T09:09:02","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/la-recherche-explore-le-diagnostic-non-invasif-de-loesophage-de-barrett\/"},"modified":"2024-10-29T10:09:05","modified_gmt":"2024-10-29T09:09:05","slug":"la-recherche-explore-le-diagnostic-non-invasif-de-loesophage-de-barrett","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/la-recherche-explore-le-diagnostic-non-invasif-de-loesophage-de-barrett\/","title":{"rendered":"La recherche explore le diagnostic non invasif de l’\u0153sophage de Barrett"},"content":{"rendered":"
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De nouvelles recherches explorent des moyens peu co\u00fbteux et non invasifs de diagnostiquer l’\u0153sophage de Barrett, une affection associ\u00e9e au cancer mortel de l’\u0153sophage, afin de trouver des strat\u00e9gies efficaces pour identifier les patients atteints de cette affection.<\/p>\n

L’\u0153sophage de Barrett est une affection dans laquelle la muqueuse le long de l’\u0153sophage (tuyau alimentaire) est endommag\u00e9e par une exposition prolong\u00e9e \u00e0 l’acide gastrique, des facteurs li\u00e9s au mode de vie tels que la consommation d’alcool et le tabagisme y contribuant.<\/p>\n

Selon une \u00e9tude, entre 2 % et 4 % des Australiens vivent avec l’\u0153sophage de Barrett, le plus souvent chez les hommes de plus de 40 ans, la plupart ignorant leur diagnostic en raison de sympt\u00f4mes sans pr\u00e9tention similaires \u00e0 des br\u00fblures d’estomac r\u00e9guli\u00e8res.<\/p>\n

\u00ab\u00a0Dans la plupart des pays industrialis\u00e9s, y compris l’Australie, l’incidence des cancers de l’\u0153sophage a quintupl\u00e9 au cours des 40 derni\u00e8res ann\u00e9es et presque tous ces cancers proviennent de l’\u0153sophage de Barrett sous-jacent\u00a0\u00bb, explique l’auteur principal, le Dr Norma Bulamu du College of Medicine and Public. Sant\u00e9.<\/p>\n

\u00ab\u00a0L’\u0153sophage de Barrett est important sur le plan clinique car ceux qui en sont atteints sont pr\u00e9dispos\u00e9s au cancer de l’\u0153sophage, qui reste l’une des formes les plus mortelles de cancer gastro-intestinal, avec un taux de survie \u00e0 cinq ans d’environ 20 %.<\/p>\n

\u00ab\u00a0C’est relativement faible par rapport \u00e0 d’autres cancers, donc j’esp\u00e8re que les connaissances que nous tirons de cette recherche pourront \u00eatre traduites en de meilleures fa\u00e7ons d’identifier et de traiter l’\u0153sophage de Barrett afin de r\u00e9duire le risque qu’il se d\u00e9veloppe en cancer de l’\u0153sophage et d’augmenter la survie des patients.\u00a0\u00bb<\/p>\n

Le diagnostic de l’\u0153sophage de Barrett est g\u00e9n\u00e9ralement pos\u00e9 \u00e0 la suite d’une endoscopie, une proc\u00e9dure invasive au cours de laquelle une cam\u00e9ra examine la muqueuse de l’\u0153sophage.<\/p>\n

La recherche, publi\u00e9e dans le Journal de gastroent\u00e9rologie et d’h\u00e9patologie<\/i>sugg\u00e8re d’utiliser une strat\u00e9gie en plusieurs \u00e9tapes pour identifier l’\u0153sophage de Barrett dans la communaut\u00e9, qui commence par l’\u00e9valuation des niveaux de risque des patients, suivie de dispositifs moins invasifs et ne se termine que par une endoscopie si n\u00e9cessaire.<\/p>\n

L’utilisation de dispositifs moins invasifs, tels qu’un test non endoscopique dans lequel un dispositif de la taille d’une pilule est aval\u00e9 pour collecter des cellules \u0153sophagiennes, puis r\u00e9cup\u00e9r\u00e9 via une ficelle et test\u00e9, a le potentiel d’\u00eatre appliqu\u00e9 dans le cadre d’une strat\u00e9gie de d\u00e9pistage, bien que ces dispositifs ne soient actuellement pas utilis\u00e9s. disponible en Australie.<\/p>\n

\u00ab\u00a0Actuellement, il n’existe pas de d\u00e9pistage de l’\u0153sophage de Barrett. Son identification est opportuniste et le test se limite \u00e0 une endoscopie, qui est non seulement une proc\u00e9dure invasive pour les patients, mais \u00e9galement co\u00fbteuse pour le syst\u00e8me de sant\u00e9\u00a0\u00bb, explique le Dr Bulamu.<\/p>\n

\u00ab\u00a0Une strat\u00e9gie en plusieurs \u00e9tapes est g\u00e9n\u00e9ralement plus \u00e9conomique que le recours direct \u00e0 une endoscopie. L’acquisition de dispositifs non endoscopiques moins invasifs, combin\u00e9e \u00e0 une \u00e9valuation des risques, constitue donc une premi\u00e8re \u00e9tape prometteuse dans le d\u00e9veloppement d’une approche de d\u00e9pistage efficace et rentable. \u00ab\u00a0.<\/p>\n

Le professeur David Watson, chercheur principal, affirme que l’\u00e9tude a \u00e9galement \u00e9valu\u00e9 des outils de d\u00e9pistage \u00e0 base de s\u00e9rum ou de sang, mais il a \u00e9t\u00e9 constat\u00e9 que ceux-ci ajoutaient des co\u00fbts substantiels sans am\u00e9liorer de mani\u00e8re significative la pr\u00e9cision du diagnostic. Pour que les outils bas\u00e9s sur le sang soient viables, ils doivent soit atteindre une sensibilit\u00e9 et une sp\u00e9cificit\u00e9 nettement plus \u00e9lev\u00e9es, soit \u00eatre propos\u00e9s \u00e0 un prix inf\u00e9rieur.<\/p>\n

\u00ab\u00a0Si notre approche peut \u00eatre transpos\u00e9e en clinique, elle pourrait alors ouvrir la voie au d\u00e9pistage, les patients identifi\u00e9s avec l’\u0153sophage de Barrett \u00e9tant ensuite inscrits dans une surveillance r\u00e9guli\u00e8re, facilitant ainsi un diagnostic et un traitement plus pr\u00e9coces, notamment pour identifier les personnes atteintes d’un stade pr\u00e9coce, ou courent un risque accru de d\u00e9velopper un cancer de l’\u0153sophage\u00a0\u00bb, d\u00e9clare le professeur Watson<\/p>\n

Bien que la recherche soit prometteuse, les chercheurs reconnaissent certaines limites et affirment que les r\u00e9sultats justifient des investigations et des analyses plus approfondies compte tenu des avantages en mati\u00e8re de qualit\u00e9 de vie et de survie r\u00e9sultant de l’identification pr\u00e9coce du cancer de l’\u0153sophage.<\/p>\n

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