{"id":1691,"date":"2024-10-28T17:59:04","date_gmt":"2024-10-28T16:59:04","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/un-nouveau-compose-reduit-la-charge-parasitaire-cryptosporidium-de-998\/"},"modified":"2024-10-28T17:59:09","modified_gmt":"2024-10-28T16:59:09","slug":"un-nouveau-compose-reduit-la-charge-parasitaire-cryptosporidium-de-998","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/un-nouveau-compose-reduit-la-charge-parasitaire-cryptosporidium-de-998\/","title":{"rendered":"Un nouveau compos\u00e9 r\u00e9duit la charge parasitaire Cryptosporidium de 99,8\u00a0%"},"content":{"rendered":"
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Des scientifiques de l\u2019Universit\u00e9 de Dundee et de l\u2019Universit\u00e9 du Vermont ont identifi\u00e9 deux compos\u00e9s qui pourraient conduire \u00e0 des traitements efficaces contre la cryptosporidiose (Crypto). La maladie touche de mani\u00e8re disproportionn\u00e9e les enfants de moins de cinq ans qui souffrent de malnutrition, souvent mortellement, ce qui en fait l’une des principales causes de d\u00e9c\u00e8s chez les enfants dans le monde.<\/p>\n

La crypto est caus\u00e9e par un parasite tr\u00e8s difficile \u00e0 \u00e9liminer. Le seul m\u00e9dicament existant, le nitazoxanide, a une approbation et une efficacit\u00e9 limit\u00e9es chez les patients immunod\u00e9prim\u00e9s et les enfants malnutris. En l\u2019absence de vaccin disponible, de traitement fiable et efficace et de centaines de milliers de vies en danger chaque ann\u00e9e, il existe un besoin urgent de nouveaux traitements.<\/p>\n

Les cryptoparasites r\u00e9sident dans une vacuole parasitophore intracellulaire mais extracytoplasmique dans les cellules \u00e9pith\u00e9liales de l’intestin gr\u00eale. Essentiellement, le parasite fabrique un petit cocon \u00e0 partir du tissu cellulaire de la paroi intestinale et forme une coque protectrice secondaire \u00e0 l\u2019int\u00e9rieur de ce cocon.<\/p>\n

Cette configuration unique rend le ciblage des m\u00e9dicaments difficile. Les traitements efficaces doivent p\u00e9n\u00e9trer \u00e0 la fois la membrane cellulaire intestinale et la couche protectrice pour atteindre le parasite \u00e0 l\u2019int\u00e9rieur.<\/p>\n

Dans une \u00e9tude, \u00ab les inhibiteurs de la Cryptosporidium lysyl-ARNt synth\u00e9tase d\u00e9finissent l’interaction entre la solubilit\u00e9 et la perm\u00e9abilit\u00e9 requise pour atteindre l’efficacit\u00e9 \u00bb, publi\u00e9e dans M\u00e9decine translationnelle scientifique<\/i>les chercheurs d\u00e9taillent la nature complexe de la lutte contre la cryptographie et testent des strat\u00e9gies pour surmonter ces d\u00e9fis. Les r\u00e9sultats \u00e9tablissent qu\u2019il est essentiel d\u2019\u00e9quilibrer la solubilit\u00e9 et la perm\u00e9abilit\u00e9 pour optimiser l\u2019efficacit\u00e9 des m\u00e9dicaments anti-cryptosporidiaux.<\/p>\n

Les chercheurs se sont concentr\u00e9s sur l\u2019inhibition de la lysyl-ARNt synth\u00e9tase (KRS), une enzyme essentielle \u00e0 la survie des parasites. En dressant le profil d’un ensemble diversifi\u00e9 d’inhibiteurs puissants du KRS, ils visaient \u00e0 identifier les propri\u00e9t\u00e9s physicochimiques et pharmacocin\u00e9tiques optimales requises pour atteindre le parasite dans un mod\u00e8le d’infection murine. Quatorze compos\u00e9s ont \u00e9t\u00e9 s\u00e9lectionn\u00e9s en fonction de leurs caract\u00e9ristiques de solubilit\u00e9 et de perm\u00e9abilit\u00e9.<\/p>\n

Les compos\u00e9s pr\u00e9sentant une solubilit\u00e9 ou une perm\u00e9abilit\u00e9 restreinte ont d\u00e9montr\u00e9 la plus forte r\u00e9duction de l’excr\u00e9tion parasitaire chez la souris. Deux compos\u00e9s (DDD489 et DDD508) ont \u00e9t\u00e9 identifi\u00e9s comme \u00e9tant les plus efficaces, atteignant une r\u00e9duction parasitaire de plus de 99,8\u00a0% sans rechute ni recrudescence.<\/p>\n

Les deux compos\u00e9s ont \u00e9galement r\u00e9duit les parasites dans un mod\u00e8le de veau, les veaux trait\u00e9s pr\u00e9sentant une gravit\u00e9 de la diarrh\u00e9e consid\u00e9rablement r\u00e9duite par rapport aux groupes t\u00e9moins.<\/p>\n

DDD489 et DDD508 ont \u00e9t\u00e9 s\u00e9lectionn\u00e9s pour progresser vers des \u00e9tudes de s\u00e9curit\u00e9 pr\u00e9cliniques, \u00e9largissant ainsi les options de traitement potentielles pour la cryptosporidiose.<\/p>\n

Ces r\u00e9sultats fournissent un guide sur les propri\u00e9t\u00e9s physicochimiques et pharmacocin\u00e9tiques requises pour un traitement efficace de la cryptosporidiose. Faire progresser ces compos\u00e9s vers des \u00e9tudes de s\u00e9curit\u00e9 pr\u00e9cliniques est la premi\u00e8re \u00e9tape dans le d\u00e9veloppement d\u2019un traitement pour cette maladie infectieuse n\u00e9glig\u00e9e.<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Des scientifiques de l\u2019Universit\u00e9 de Dundee et de l\u2019Universit\u00e9 du Vermont ont identifi\u00e9 deux compos\u00e9s<\/p>\n","protected":false},"author":1,"featured_media":1692,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[986,1314,2066,495,2065,658],"class_list":["post-1691","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-charge","tag-compose","tag-cryptosporidium","tag-nouveau","tag-parasitaire","tag-reduit","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUn nouveau compos\u00e9 r\u00e9duit la charge parasitaire Cryptosporidium de 99,8\u00a0% - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/un-nouveau-compose-reduit-la-charge-parasitaire-cryptosporidium-de-998\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un nouveau compos\u00e9 r\u00e9duit la charge parasitaire Cryptosporidium de 99,8\u00a0% - 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