{"id":1551,"date":"2024-10-23T23:00:23","date_gmt":"2024-10-23T21:00:23","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/il-savere-que-les-vaccinations-repetees-contre-le-covid-renforcent-limmunite-des-muqueuses-contre-le-virus\/"},"modified":"2024-10-23T23:00:25","modified_gmt":"2024-10-23T21:00:25","slug":"il-savere-que-les-vaccinations-repetees-contre-le-covid-renforcent-limmunite-des-muqueuses-contre-le-virus","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/il-savere-que-les-vaccinations-repetees-contre-le-covid-renforcent-limmunite-des-muqueuses-contre-le-virus\/","title":{"rendered":"Il s\u2019av\u00e8re que les vaccinations r\u00e9p\u00e9t\u00e9es contre le COVID renforcent l\u2019immunit\u00e9 des muqueuses contre le virus"},"content":{"rendered":"
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Pendant la pand\u00e9mie de COVID, beaucoup d\u2019entre nous ont re\u00e7u plusieurs vaccins \u00e0 ARNm. De nouveaux travaux men\u00e9s par des chercheurs du Centre de recherche sur l’inflammation VIB-UGent, de l’Universit\u00e9 de Gand et de l’h\u00f4pital universitaire de Gand, entre autres, ont r\u00e9v\u00e9l\u00e9 que de telles vaccinations r\u00e9p\u00e9t\u00e9es conduisent \u00e0 la pr\u00e9sence d’anticorps muqueux, par exemple \u00e0 l’int\u00e9rieur du nez. Leur travail appara\u00eet dans M\u00e9decine translationnelle scientifique.<\/i><\/p>\n

Une partie de la strat\u00e9gie mondiale de r\u00e9ponse \u00e0 la pand\u00e9mie de COVID implique l\u2019administration de rappels, ou de mises \u00e0 jour de vaccins, pour garantir la protection contre les nouvelles variantes du virus SARS-CoV-2.<\/p>\n

Les chercheurs ont entrepris d\u2019\u00e9tudier les effets de plusieurs vaccins \u00e0 ARNm sur l\u2019immunit\u00e9 des muqueuses, en se r\u00e9f\u00e9rant aux muqueuses telles que celles situ\u00e9es \u00e0 l\u2019int\u00e9rieur de notre nez. Plus pr\u00e9cis\u00e9ment, la recherche a impliqu\u00e9 une cohorte de 183 participants qui ont \u00e9t\u00e9 \u00e9chantillonn\u00e9s \u00e0 plusieurs moments apr\u00e8s les vaccinations primaires et de rappel.<\/p>\n

doctorat L’\u00e9tudiant Jozefien Declercq (VIB-UGent) explique : \u00ab\u00a0Nous avons constat\u00e9 que les individus ayant re\u00e7u plusieurs doses de vaccins \u00e0 ARNm pr\u00e9sentaient une augmentation marqu\u00e9e des anticorps neutralisants dans les s\u00e9cr\u00e9tions nasales, qui sont essentiels pour bloquer l’entr\u00e9e du virus. Non seulement cela, mais les r\u00e9ponses immunitaires g\u00e9n\u00e9r\u00e9es par les vaccins \u00e0 ARNm peuvent persister plus longtemps qu\u2019on ne le pensait auparavant, ce qui laisse esp\u00e9rer une protection durable contre les variantes \u00e9mergentes du virus. \u00bb<\/p>\n

Du sang au nez<\/h2>\n

Mais comment les anticorps produits en r\u00e9ponse au vaccin parviennent-ils au nez ?<\/p>\n

Le professeur Stijn Vanhee (VIB-UGent), co-auteur principal de l’\u00e9tude, explique. \u00ab\u00a0En utilisant un mod\u00e8le murin, nous avons d\u00e9couvert que la plupart des anticorps neutralisants des muqueuses \u00e9taient d’origine syst\u00e9mique, les anticorps circulant dans le sang migrant vers la muqueuse respiratoire du nez, ce qui sugg\u00e8re qu’une vaccination r\u00e9p\u00e9t\u00e9e stimule la production syst\u00e9mique d’anticorps pouvant atteindre les muqueuses.\u00a0\u00bb<\/p>\n

Les r\u00e9sultats sugg\u00e8rent que les vaccinations r\u00e9p\u00e9t\u00e9es renforcent non seulement l\u2019immunit\u00e9 syst\u00e9mique, mais am\u00e9liorent \u00e9galement les r\u00e9ponses anticorps des muqueuses, offrant ainsi une d\u00e9fense plus robuste contre le virus.<\/p>\n

Le professeur Linos Vandekerckhove (Universit\u00e9 de Gand), co-auteur principal de l’\u00e9tude, souligne le r\u00f4le essentiel de l’immunit\u00e9 des muqueuses dans la lutte contre le COVID-19 : \u00ab Notre \u00e9tude fournit des preuves convaincantes que des vaccinations r\u00e9p\u00e9t\u00e9es \u00e0 base d’ARNm peuvent am\u00e9liorer les r\u00e9ponses en anticorps des muqueuses, ou stimuler les r\u00e9ponses muqueuses induites par une infection pr\u00e9existante, qui sont essentielles pour pr\u00e9venir l’infection aux points d’entr\u00e9e du virus. Cela pourrait avoir de profondes implications pour les strat\u00e9gies de sant\u00e9 publique \u00e0 l’avenir, en particulier alors que nous sommes confront\u00e9s \u00e0 de nouvelles variantes pr\u00e9occupantes.<\/p>\n

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Pendant la pand\u00e9mie de COVID, beaucoup d\u2019entre nous ont re\u00e7u plusieurs vaccins \u00e0 ARNm. 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