{"id":1536,"date":"2024-10-23T10:56:16","date_gmt":"2024-10-23T08:56:16","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/comment-le-sras-cov-2-defait-la-reponse-immunitaire-innee\/"},"modified":"2024-10-23T10:56:18","modified_gmt":"2024-10-23T08:56:18","slug":"comment-le-sras-cov-2-defait-la-reponse-immunitaire-innee","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/comment-le-sras-cov-2-defait-la-reponse-immunitaire-innee\/","title":{"rendered":"Comment le SRAS-CoV-2 d\u00e9fait la r\u00e9ponse immunitaire inn\u00e9e"},"content":{"rendered":"
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Le nouveau coronavirus SARS-CoV-2 poss\u00e8de une enzyme qui peut contrecarrer le m\u00e9canisme de d\u00e9fense inn\u00e9 d’une cellule contre les virus, expliquant pourquoi il est plus infectieux que les pr\u00e9c\u00e9dents virus responsables du SRAS et du MERS. Une d\u00e9couverte de l\u2019Universit\u00e9 de Kobe pourrait ouvrir la voie au d\u00e9veloppement de m\u00e9dicaments plus efficaces contre cette maladie et \u00e9ventuellement contre d\u2019autres maladies similaires.<\/p>\n

Lorsqu’un virus attaque, la r\u00e9ponse immunitaire de l’organisme comporte deux couches de d\u00e9fense de base\u00a0: le syst\u00e8me immunitaire inn\u00e9 et adaptatif. Alors que le syst\u00e8me immunitaire adaptatif se renforce contre un agent pathog\u00e8ne sp\u00e9cifique \u00e0 mesure que le corps y est expos\u00e9 \u00e0 plusieurs reprises et constitue la base des vaccinations, le syst\u00e8me immunitaire inn\u00e9 est un assortiment de m\u00e9canismes mol\u00e9culaires qui agissent contre un large \u00e9ventail d’agents pathog\u00e8nes \u00e0 un niveau de base. .<\/p>\n

Le virologue de l’Universit\u00e9 de Kobe, Shoji Ikuo, d\u00e9clare : \u00ab\u00a0Le nouveau coronavirus, cependant, est si contagieux que nous nous demandons quels m\u00e9canismes intelligents le virus utilise pour \u00e9chapper si efficacement au syst\u00e8me immunitaire inn\u00e9.\u00a0\u00bb<\/p>\n

L’\u00e9quipe de Shoji a pr\u00e9c\u00e9demment travaill\u00e9 sur la r\u00e9ponse immunitaire aux virus de l’h\u00e9patite et a \u00e9tudi\u00e9 le r\u00f4le d’une \u00e9tiquette mol\u00e9culaire appel\u00e9e \u00ab ISG15 \u00bb que le syst\u00e8me immunitaire inn\u00e9 attache aux \u00e9l\u00e9ments constitutifs du virus. Ayant appris que le nouveau coronavirus poss\u00e8de une enzyme particuli\u00e8rement efficace pour \u00e9liminer cette balise, il a d\u00e9cid\u00e9 d’utiliser l’expertise de son \u00e9quipe pour \u00e9lucider l’effet de la balise ISG15 sur le coronavirus et le m\u00e9canisme des contre-mesures du virus.<\/p>\n

Dans un article du Journal de virologie<\/i>l’\u00e9quipe dirig\u00e9e par l’Universit\u00e9 de Kobe est d\u00e9sormais la premi\u00e8re \u00e0 signaler que l’\u00e9tiquette ISG15 est attach\u00e9e \u00e0 un emplacement sp\u00e9cifique de la prot\u00e9ine de la nucl\u00e9ocapside du virus, l’\u00e9chafaudage qui emballe le mat\u00e9riel g\u00e9n\u00e9tique de l’agent pathog\u00e8ne.<\/p>\n

Pour que le virus s’assemble, de nombreuses copies de la prot\u00e9ine nucl\u00e9ocapside doivent s’attacher les unes aux autres, mais l’\u00e9tiquette ISG15 l’emp\u00eache, ce qui est le m\u00e9canisme derri\u00e8re l’action antivirale de l’\u00e9tiquette. \u00ab\u00a0Cependant, le nouveau coronavirus poss\u00e8de \u00e9galement une enzyme capable d’\u00e9liminer les \u00e9tiquettes de sa nucl\u00e9ocapside, r\u00e9cup\u00e9rant ainsi sa capacit\u00e9 \u00e0 assembler de nouveaux virus et d\u00e9passant ainsi la r\u00e9ponse immunitaire inn\u00e9e\u00a0\u00bb, explique Shoji.<\/p>\n

Le nouveau coronavirus partage de nombreux traits avec les virus du SRAS et du MERS, qui appartiennent tous \u00e0 la m\u00eame famille de virus. Et ces virus poss\u00e8dent \u00e9galement une enzyme capable de supprimer l\u2019\u00e9tiquette ISG15. Cependant, l’\u00e9quipe de Shoji a constat\u00e9 que leurs versions sont moins efficaces que celle du nouveau coronavirus. Et en fait, il a \u00e9t\u00e9 rapport\u00e9 r\u00e9cemment que les enzymes des virus pr\u00e9c\u00e9dents avaient une cible principale diff\u00e9rente.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats sugg\u00e8rent que le nouveau coronavirus est tout simplement plus efficace pour \u00e9chapper \u00e0 cet aspect du m\u00e9canisme de d\u00e9fense du syst\u00e8me immunitaire inn\u00e9, ce qui explique pourquoi il est si infectieux\u00a0\u00bb, explique Shoji.<\/p>\n

Mais comprendre pourquoi le nouveau coronavirus est si efficace ouvre \u00e9galement la voie au d\u00e9veloppement de traitements plus efficaces.<\/p>\n

Le chercheur explique : \u00ab Nous pourrions \u00eatre en mesure de d\u00e9velopper de nouveaux m\u00e9dicaments antiviraux si nous pouvons inhiber la fonction de l’enzyme virale qui supprime l’\u00e9tiquette ISG15. Les strat\u00e9gies th\u00e9rapeutiques futures pourraient \u00e9galement inclure des agents antiviraux qui ciblent directement la prot\u00e9ine de la nucl\u00e9ocapside, ou une combinaison de ces derniers. deux approches.\u00a0\u00bb<\/p>\n

<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Le nouveau coronavirus SARS-CoV-2 poss\u00e8de une enzyme qui peut contrecarrer le m\u00e9canisme de d\u00e9fense inn\u00e9<\/p>\n","protected":false},"author":1,"featured_media":1537,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[182,1914,834,1915,326,1913],"class_list":["post-1536","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-comment","tag-defait","tag-immunitaire","tag-innee","tag-reponse","tag-srascov2","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nComment le SRAS-CoV-2 d\u00e9fait la r\u00e9ponse immunitaire inn\u00e9e - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/comment-le-sras-cov-2-defait-la-reponse-immunitaire-innee\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comment le SRAS-CoV-2 d\u00e9fait la r\u00e9ponse immunitaire inn\u00e9e - 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