{"id":11718,"date":"2025-11-14T15:52:36","date_gmt":"2025-11-14T14:52:36","guid":{"rendered":"https:\/\/rvh-synergie.org\/actualites\/une-hormone-metabolique-renforce-la-resilience-contre-les-symptomes-de-la-grippe\/"},"modified":"2025-11-14T15:52:47","modified_gmt":"2025-11-14T14:52:47","slug":"une-hormone-metabolique-renforce-la-resilience-contre-les-symptomes-de-la-grippe","status":"publish","type":"post","link":"https:\/\/rvh-synergie.org\/actualites\/une-hormone-metabolique-renforce-la-resilience-contre-les-symptomes-de-la-grippe\/","title":{"rendered":"Une hormone m\u00e9tabolique renforce la r\u00e9silience contre les sympt\u00f4mes de la grippe"},"content":{"rendered":"
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Une hormone connue pour r\u00e9guler l’\u00e9quilibre \u00e9nerg\u00e9tique aide \u00e9galement l’organisme \u00e0 faire face \u00e0 la grippe en d\u00e9clenchant des r\u00e9ponses protectrices dans le cerveau, selon une \u00e9tude men\u00e9e par des chercheurs du UT Southwestern Medical Center.<\/p>\n

Les r\u00e9sultats, publi\u00e9s dans le Actes de l’Acad\u00e9mie nationale des sciences<\/i>sugg\u00e8rent que cibler cette voie pourrait offrir une nouvelle approche pharmacologique pour traiter la grippe.<\/p>\n

\u00ab\u00a0Notre travail d\u00e9montre que le FGF21, une hormone induite par le stress qui r\u00e9gule le m\u00e9tabolisme du corps entier, agit sur le cerveau pour le prot\u00e9ger contre l’hypothermie et la perte de poids provoqu\u00e9es par l’infection grippale\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur principal Steven Kliewer, Ph.D., professeur de biologie mol\u00e9culaire et de pharmacologie \u00e0 l’UT Southwestern.<\/p>\n

L’\u00e9tude a r\u00e9v\u00e9l\u00e9 que les niveaux de facteur de croissance des fibroblastes 21 (FGF21) ont augment\u00e9 chez les humains et les souris au cours de l’infection grippale. Chez la souris, l’hormone a activ\u00e9 une r\u00e9gion du cerveau qui r\u00e9gule le syst\u00e8me nerveux noradr\u00e9nergique, provoquant la production de chaleur \u00e0 partir des tissus qui aident \u00e0 r\u00e9guler la temp\u00e9rature corporelle chez la souris.<\/p>\n

Comment FGF21 aide \u00e0 combattre les infections<\/h2>\n

Cette r\u00e9ponse thermog\u00e9nique a permis de stabiliser la temp\u00e9rature corporelle et d\u2019am\u00e9liorer la r\u00e9ponse \u00e0 l\u2019infection grippale. Les souris d\u00e9pourvues de FGF21 ou de son r\u00e9cepteur dans ces neurones ont r\u00e9cup\u00e9r\u00e9 plus lentement, tandis que le traitement avec le FGF21 pharmacologique a am\u00e9lior\u00e9 la r\u00e9cup\u00e9ration.<\/p>\n

L\u2019hormone n\u2019a pas modifi\u00e9 les niveaux viraux, ce qui indique qu\u2019elle prot\u00e8ge le corps en att\u00e9nuant le stress physiologique de l\u2019infection plut\u00f4t qu\u2019en ciblant directement le virus. Collectivement, ces r\u00e9sultats sugg\u00e8rent que le FGF21 pourrait aider l\u2019organisme \u00e0 r\u00e9pondre plus efficacement \u00e0 toute une s\u00e9rie d\u2019infections, et pas seulement \u00e0 la grippe.<\/p>\n

\u00ab\u00a0Pour les cas graves d’infection grippale, les soins sont principalement de soutien\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Kliewer. \u00ab\u00a0Nos r\u00e9sultats sugg\u00e8rent une nouvelle approche pharmacologique pour traiter la grippe. D’autres \u00e9tudes sont n\u00e9cessaires pour d\u00e9terminer si ces r\u00e9sultats sont applicables \u00e0 d’autres infections.\u00a0\u00bb<\/p>\n

S’appuyant sur des d\u00e9cennies de recherche<\/h2>\n

La recherche s’appuie sur des d\u00e9cennies de travail du laboratoire Mangelsdorf\/Kliewer de l’UTSW, qui a pr\u00e9c\u00e9demment identifi\u00e9 le FGF21 comme une hormone produite par le foie en r\u00e9ponse \u00e0 des stress m\u00e9taboliques tels que le je\u00fbne et l’exposition \u00e0 l’alcool.<\/p>\n

La nouvelle \u00e9tude \u00e9tend ces travaux \u00e0 l\u2019infection, montrant que le FGF21 utilise la m\u00eame voie de signalisation foie-cerveau pour aider l\u2019organisme \u00e0 maintenir son \u00e9quilibre m\u00e9tabolique pendant la maladie.<\/p>\n

\u00ab\u00a0Ces r\u00e9sultats d\u00e9montrent que le syst\u00e8me immunitaire n’est pas le seul \u00e9l\u00e9ment essentiel de la r\u00e9ponse \u00e0 l’infection\u00a0\u00bb, a d\u00e9clar\u00e9 l’auteur correspondant Kartik Rajagopalan, MD, Ph.D., professeur adjoint de m\u00e9decine interne \u00e0 la division de m\u00e9decine pulmonaire et de soins intensifs et \u00e0 l’institut de recherche du centre m\u00e9dical pour enfants de l’UT Southwestern.<\/p>\n

\u00ab\u00a0Certains signaux sont envoy\u00e9s au cerveau qui reprogramment le m\u00e9tabolisme pour une r\u00e9ponse optimale.\u00a0\u00bb<\/p>\n

Collaboration et implications cliniques<\/h2>\n

Le travail \u00e9tait une collaboration entre les d\u00e9partements de pharmacologie, de biologie mol\u00e9culaire et de m\u00e9decine interne de l’UT Southwestern, r\u00e9unissant des expertises en mati\u00e8re d’infection, d’endocrinologie et de neurosciences. Il a \u00e9galement impliqu\u00e9 des stagiaires \u00e0 plusieurs niveaux, y compris des boursiers postdoctoraux et cliniques, et a incorpor\u00e9 des donn\u00e9es humaines montrant que les niveaux de FGF21 augmentent lors d’une infection grippale.<\/p>\n

\u00ab\u00a0Ce projet met en valeur le pouvoir de l’int\u00e9gration de la recherche fondamentale et clinique, qui constitue une force d\u00e9terminante de l’UT Southwestern\u00a0\u00bb, a d\u00e9clar\u00e9 le Dr Kliewer. \u00ab\u00a0Il y a tr\u00e8s peu d’endroits o\u00f9 un projet comme celui-ci aurait pu fleurir. Nous avons la chance qu’UT Southwestern en fasse partie.\u00a0\u00bb<\/p>\n

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Une hormone connue pour r\u00e9guler l’\u00e9quilibre \u00e9nerg\u00e9tique aide \u00e9galement l’organisme \u00e0 faire face \u00e0 la<\/p>\n","protected":false},"author":1,"featured_media":11719,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86],"tags":[90,419,428,49,2526,2172,5939,42,47],"class_list":["post-11718","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-les-maladies","tag-contre","tag-grippe","tag-hormone","tag-les","tag-metabolique","tag-renforce","tag-resilience","tag-symptomes","tag-une","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50","resize-featured-image"],"yoast_head":"\nUne hormone m\u00e9tabolique renforce la r\u00e9silience contre les sympt\u00f4mes de la grippe - RVH-Synergie.org<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rvh-synergie.org\/actualites\/une-hormone-metabolique-renforce-la-resilience-contre-les-symptomes-de-la-grippe\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une hormone m\u00e9tabolique renforce la r\u00e9silience contre les sympt\u00f4mes de la grippe - 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